PLoS ONE
Articles in this Issue
Predicting and explaining life satisfaction among older adults using tree-based ensemble models and SHAP: Evidence from the digital divide survey
As digital transformation continues to penetrate various sectors of society, the issue of the digital divide has become increasingly prominent. Against the backdrop of accelerating population aging, t...
Diagnostic yield of exome sequencing in nonobstructive azoospermia (NOA): A systematic review and meta-analysis
Azoospermia is considered as the most severe form of male infertility. The application value of exome sequencing (ES) in males with non-obstructive azoospermia (NOA) remains unclear. This study aims t...
Phase II trial protocol of focal prostate ablation combined with androgen deprivation therapy for prostate cancer treatment
Background Prostate cancer (PCa) is one of the most commonly diagnosed cancers. Treatments for PCa with less adverse effects than whole gland interventions, such as focal therapy (...
Spatial autocorrelation and determinants of low uptake of breast cancer screening among women of reproductive age: A mixed-effect multilevel analysis of Tanzanian population-based survey
Introduction Breast cancer remains an important public health problem with high mortality in low-income countries like Tanzania. This is because of the low uptake of screening for...
SEANN: A domain-informed neural network for epidemiological insights
In epidemiology, traditional statistical methods such as logistic regression, linear regression, and other parametric models are commonly employed to investigate associations between predictors and he...
The innate immune IMD pathway is a key regulator of gut microbiome and metabolic homeostasis in the black tiger shrimp (Penaeus monodon)
The gut microbiome plays a fundamental role in host health and homeostasis, yet immune mechanisms regulating this relationship remain poorly understood in commercially important invertebrate such as t...
Carbon footprint comparison of video intubation tools: Disposable laryngoscopes, reusable laryngoscopes, and stylets
Purpose As healthcare systems grapple with their 5% global carbon footprint contribution, sustainable medical device selection emerges as a critical decarbonization lever. This lif...
Disruption of epidermal growth factor receptor signaling and cytoskeletal dynamics by mebendazole and gefitinib synergistically impairs paracrine cytokine signaling in non-small cell lung cancer and triple-negative breast cancer Cell lines
Background Aberrant paracrine cytokine signaling and dysregulated signal transduction are critical drivers of tumor progression and therapeutic resistance in aggressive cancers suc...
Safety of íntravitreal panitumumab combined with intravitreal ranibizumab in rabbits
Purpose To examine the safety of intravitreally applied epidermal growth factor (EGF) receptor antibody panitumumab combined with intravitreally injected vascular endothelial growt...
Optimizing the preparation of labeled N-glycans for rapid, simplified, and high-precision analysis
Glycan structures hold promise as biomarkers for the early detection of diseases, owing to their sensitive reflection of cellular states. However, glycan analysis remains complex and time-consuming, a...
Assessment of the impact of the new blister packaging of Biktarvy® (B/F/TAF) on treatment satisfaction of people living with HIV
Background Antiretroviral therapy (ART) is highly effective in people living with HIV (PLHIV), but its success depends on treatment satisfaction and adherenc...
Associations between serum pigment epithelium-derived factor and physical performance in older women: The Otassha study
Pigment epithelium-derived factor (PEDF) contributes to the beneficial effects of exercise by suppressing cellular senescence in multiple organs. Its expression declines in the skeletal muscle of aged...
Diagnostic performance of four AI tools in pharmacology MCQs: Accuracy, sensitivity, and specificity
Background The rapid rise of AI in medical and pharmaceutical education has engendered much interest; however, a knowledge gap still exists in the evaluation of performances of the...
Effect of obesity and exercise training on circulating lipids in American Indian adolescents
Childhood dyslipidemia is predictive of future cardiometabolic disease. We determined the impact of obesity (Ob) and an exercise program on lipids in American Indian adolescents. This is a secondary a...
PERMA-guided multi-topology graph neural networks for cross-cultural student well-being prediction
Student well-being prediction is of great significance for promoting personalized education and preventing mental health problems, but existing methods suffer from limitations including lack of psycho...
Prevalence and factors associated with hyperglycemia among children living with HIV on dolutegravir in Kabale district, southwestern Uganda
Background Undiagnosed and poorly managed high blood sugar levels can result in short- and long-term complications in children. Following worldwide introduction of dolutegravir bas...
Correction: From fishing village to atomic town and present: A grounded theory study
Vehicle driving area detection and sensor data preprocessing based on deep learning
With the rapid development of intelligent vehicles, it has become particularly important to effectively detect the environment of the vehicle’s driving area. A vehicle driving road recognition algorit...
Spatiotemporal variation characteristics and influencing factors of snow density in the High Mountain Asia from 1960 to 2023
Under the context of climate change, significant variations in snow density have been observed in the High Mountain Asia, however, its spatiotemporal patterns and underlying drivers remain incompletel...
Treating a friend to voter registration in a Divided America
As partisanship strengthens in the United States, unaffiliated voter registration is also increasing. We conducted an original survey experiment to understand voter registration choices among register...
Ambient temperature, suicide, and urbanicity: A nationwide time-stratified case-crossover study in South Korea
Several studies have examined the nationwide or multi-region relationship between ambient temperature and suicide mortality; however, evidence of comprehensive roles of urbanicity that can affect temp...
Parent-set bedtime in adolescence is associated with future cardiovascular disease risk: Evidence from the Add Health study
Parent-set bedtimes have been linked to a lower prevalence of key cardiovascular disease (CVD) risk factors in adolescents. However, little is known about how parent-set bedtimes during adolescence af...
A novel prediction approach of three-dimensional thermal fatigue cracks in thermal compression bonding electrodes based on digital twin
Thermal compression bonding (TCB) electrodes that initiate thermal fatigue cracks compromise reliability and takt time in electronic manufacturing, and accurate prediction of three-dimensional (3D) el...
Genotypic variability of Tunisian maize landraces: A valuable genetic resource to mitigate drought and heat stress in the Mediterranean basin
This study aimed to assess the drought and heat stress tolerance of nine Tunisian maize populations and their potential stress tolerance mechanisms. Over two years, nine Tunisian maize populations wer...
Grading by size to reduce the opportunity for domestication selection in hatchery-reared steelhead (Oncorhynchus mykiss)
Fish that are produced in hatcheries often produce fewer surviving adult offspring than do wild fish when both spawn in the wild. This difference in fitness is likely due to inadvertent selection for...