PLoS ONE
Articles in this Issue
Chronic illness and extreme performance: Type 1 diabetes in ultra-endurance
Background This study explores how people with type 1 diabetes experience ultra-endurance sports, focusing on identity, self-management, and psychosocial impacts through a qualitat...
Prevalence of dry eye symptoms and associated risk factors among students at Al-Mustaqbal University, Iraq
This study aimed to estimate the prevalence, severity, and risk factors of dry eye symptoms (DES) among Iraqi university students and to examine associations with digital device use in an arid, dust-p...
Academic pressure and academic procrastination: The mediating role of negative coping strategies
Rooted in the Extended Procrastination-Health Framework, this study employed a survey of 600 Chinese university students to elucidate the mechanistic relationships among academic pressure, coping stra...
Why don’t they want to donate? Cultural and psychological factors influencing the organ donation intention among Hong Kong University students
Despite significant advances in transplantation technologies, the global gap between organ availability and demand continues to widen. Hong Kong, in particular, reports notably low organ donation rate...
Testing weight-based conditional discrimination in Goffin’s cockatoos, Cacatua goffiniana
Discrimination learning tasks are a method for investigating species’ perception of and associative learning with a particular stimulus. Goffin’s cockatoos previously required surprisingly few trials...
Epidemiological characteristics of ischemic heart disease: A comparative study between China and the world from 1990 to 2021 and prediction to 2036
Background Ischemic heart disease (IHD) is a major disease that endangers human health. There are relatively few comparative studies on the epidemiological characteristics of IHD....
Therapeutic effects of skin repair plus ointment on molecular and morphological changes in burn wounds: A rat model
Skin Repair Plus Ointment (Remanco) is an advanced formulation of the traditional Jordanian cream, which has been used for treating burn injuries and has served as an alternative remedy in northern Jo...
How similar should collaborators be in inter-organizational learning: Optimal cognitive proximity and knowledge complexity
Effective knowledge exchange is critical for innovation in knowledge-intensive sectors, yet the relationship between cognitive proximity and collaborative innovation remains underexplored in complex k...
Impact of adherence and stringency on the effectiveness of lockdown measures: A modelling study
During the COVID-19 pandemic, lockdowns were a widely used strategy to reduce disease transmission. However, there was much debate about the optimal level of strictness and duration of lockdowns. This...
Adverse event reporting of mirtazapine: A disproportionality analysis of FDA adverse event reporting system (FAERS) database from 2004–2024
Background Mirtazapine is a pharmacological agent commonly utilized as a first-line treatment for major depressive disorder, exhibiting both noradrenergic and selective serotonergi...
Fecal microbiota composition and function are associated with anxiety and depression in patients with inflammatory bowel disease
Background and aims Increasing prevalence of anxiety and depression are found in patients with inflammatory bowel disease (IBD). Altered gut microbiome may affect the brain, result...
Machine learning-based risk prediction model for cognitive dysfunction in elderly individuals
Background With the advancement of globalization, the prevalence of cognitive dysfunction in the elderly population has risen significantly. Early intervention may dramatically all...
A novel prognostic model for lung squamous cell carcinoma based on multi-omics analysis and machine learning
Lung squamous-cell carcinoma (LUSC) is a highly aggressive malignancy with a poor prognosis. Tertiary lymphoid structures (TLS) play a crucial role in the immune response and significantly influence t...
Elucidating the isorhamnetin-3-O-glucoside-iNOS interaction via molecular dynamics and Hirshfeld surface analyses
Inducible nitric oxide synthase (iNOS) remains a demanding metallo-enzyme target because the catalytic heme shapes both geometry and electrostatics at the binding site. We evaluated the dietary flavon...
ACEF score as a predictor of new-onset atrial fibrillation in patients with ST-elevation myocardial infarction: A retrospective cohort study
Background New-onset atrial fibrillation (NOAF) during acute ST-elevation myocardial infarction (STEMI) is common and linked to adverse outcomes. This study aimed to assess the pre...
The impact of COVID-19 on walking practices in Korea: Policy implications for Urban health and physical activity resilience
Background This study adopts a socio-ecological model to evaluate the individual- and community-level factors influencing walking practices among urban adults before (2018−2019) an...
Dry eye disease seasonal pattern and climatic association in Saudi Arabia using Google Trends
Purpose The study aims to investigate the dry eye search term pattern in Saudi Arabia using Google Trends, and to explore the association of weather changes on dry eye disease (DED...
Correction: LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity
Advance directives prior to COVID-19 diagnosis in a United States national healthcare system
Background An advance directive (AD) document allows a patient to indicate their health care preferences and identify an agent to make decisions on their behalf if they lose their...
Assessing readiness of health facilities for hypertension and integration with diabetes care in Bangladesh: Evidence from the National Service Provision Assessment Survey
Background Hypertension (HT) and diabetes mellitus (DM) are two major noncommunicable diseases (NCDs) with a high rate of comorbidity that utilize similar health system resources....
Retraction: Beyond emotional and spatial processes: Cognitive dysfunction in a depressive phenotype produced by long photoperiod exposure
Does local government tax competition promote industrial transformation and upgrading?
Promoting industrial transformation and upgrading (ITU) is the vital driving force for achieving high-quality economic development. This paper systematically interprets the theoretical mechanism of th...
A lightweight network for phone surface defect detection with industrial deployment on RK3568 edge devices
In smartphone production, detecting small defects on screens remains challenging due to low detection accuracy, high missed detection rates, and slow processing speeds. To address these issues, this p...
Dual niche modeling with GEE and SHAP for predicting habitat shifts of Haloxylon ammodendron and Cistanche deserticola under climate change
Haloxylon ammodendron , a keystone woody species, and its parasitic plant, Cistanche deserticola , play critical roles in sustaining arid ec...
The combination of LILRB4-targeting NK cell engagers and cGAS–STING agonists enhances the anti–multiple myeloma immune activity of NK cells
Although significant progress has been made in immune-targeted therapy for multiple myeloma (MM), it remains highly recurrent and incurable. Consequently, there is still an urgent need to develop more...