PLoS ONE
Articles in this Issue
Impact of MED12 mutation and CDK8 activity on uterine leiomyoma growth and response to gonadotropin-releasing hormone agonist treatment
MED12 exon 2 mutation is the most frequent mutation associated with uterine leiomyomas. MED12 wild-type leiomyomas have a higher growth pote...
Editorial Note: The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA
Correction: Layers of exposure risk management measures for the prevention and control of infections of healthcare workers treating COVID-19 patients
Spatial distribution and determinants of fertility preferences among female adolescents and young adults in Ethiopia
Introduction Understanding adolescents and young adults’ (AYAs) fertility preferences is crucial for guiding youth-focused family planning and predicting future fertility. However,...
Computational identification of epifriedelanol and derived analogs from Mikania cordata as potential HMG-CoA reductase inhibitors
Hypercholesterolemia, a major risk factor for cardiovascular diseases, arises from elevated blood cholesterol levels and remains a global health concern. The limitations of current therapies underscor...
Correction: Effects of dysmenorrhea on work productivity and quality of life in Japanese women: A large-scale web-based cross-sectional study
Patient death and nurses’ coping strategies: Perception of nurses at a tertiary referral hospital in Kenya
In healthcare facilities, patient deaths are a common occurrence, exposing nurses to diverse behavioral and emotional reactions, particularly within the context of resource constraints in Kenyan healt...
Correction: Nummi Digitali: A pioneering multimodal platform for numismatic heritage
Retraction: Molecular and cellular mechanisms of cigarette smoke-induced myocardial injury: Prevention by Vitamin C
Economic burden of drought using the life satisfaction approach: A case study of slum dwellers in southeast Iran
Drought is one of the most visible effects of climate change and poses significant challenges for sustainable development. Assessing the costs of drought is essential for effective policymaking, and i...
Petrogenesis and tectonic significance of the Baipu granite porphyry in the Huangtian uranium deposit, northeastern Guangdong, South China
The genetic link between Late Yanshanian granitic magmatism and uranium mineralization in South China remains a subject of active investigation, with the petrogenesis and tectonic drivers of many uran...
The association between rural/urban residence status and patient-reported outcomes in individuals with Chronic Obstructive Pulmonary Disease (COPD): Protocol for a systematic review and meta-analysis
Introduction Rural residency is associated with a disproportionate burden of chronic obstructive pulmonary disease (COPD) and poorer COPD health outcomes. While increasing focus ha...
Representativeness of a German AI-enabled data network for secondary epidemiological analysis based on electronic health records
Introduction The ongoing digitalization of medicine, increased computing power and low-cost storage capacities enable the use of AI-based algorithms for epidemiological big data an...
An integrated multi-criteria decision-making model for long-term planning of UAVs in disaster management
With their superior capabilities, unmanned aerial vehicles (UAVs) play a crucial role in search, rescue, and surveillance operations in disaster management. It is of great importance in the long run t...
Aetiology and impact of bacterial bloodstream infections in mechanically ventilated COVID-19 patients: A prospective Swedish multicenter cohort study
Objectives Critically ill COVID-19 patients admitted to the intensive care unit (ICU) are at an increased risk of acquiring bacterial bloodstream infections (BSI). We aimed to desc...
Correction: Construction and validation of an anoikis-related prognostic model for lung adenocarcinoma based on bulk and single-cell transcriptomic data
Prevalence and morphometry of the fabella in cadaveric and radiological studies: Is there a link to knee osteoarthritis?
Objective To investigate the morphometric features of the fabella in cadaveric specimens and evaluate its prevalence and potential association with knee osteoarthritis through radi...
Mechanisms of deformation and failure in colluvial slope under artificial surcharge loading
Large-scale artificial surcharge loading often triggers landslides in colluvial deposits, yet the mechanical response and failure mechanisms of such slopes under loading remain insufficiently understo...
Bridging priorities: Stakeholder preferences, networks, and barriers in road-stream crossing management
Road-stream crossings (RSCs) represent a critical nexus of infrastructure resilience and ecosystem health, yet fragmented governance and institutional silos hinder effective management. This study use...
Enhanced distance protection for HVDC lines using adaptive neuro-fuzzy inference systems
Accuracy and speed of fault detection are crucial to the performance of DC transmission systems. In this paper, a novel approach is proposed for fault detection, classification, and localization in hi...
Allostatic load and progression of cardio-renal multimorbidity: A UK biobank study
Background Cardio-renal multimorbidity (CRM), the coexistence of cardiovascular disease (CVD) and chronic kidney disease (CKD), imposes a significant healthcare burden. Allostatic...
Safety and therapeutic potential evaluation of Cefotaxime plus Polymyxin B against polymyxin-carbapenem resistant Klebsiella pneumoniae in a murine model
Objectives This study aimed to evaluate the toxicity and antibacterial efficacy of Cefotaxime/Polymyxin B combination (CTX/PMB) against a polymyxin-carbapene...
Correction: Comparative analysis of the lethality pattern of Covid-19 and the response of BRICS countries to the pandemic in the context of multilateralism: An ecological study
KALFormer: Knowledge-augmented attention learning for long-term time series forecasting with transformer
Time series forecasting remains a fundamental yet challenging task due to its inherent non-linear dynamics, inter-variable dependencies, and long-term temporal correlations. Existing approaches often...
Do hypoechoic endometrial cystic appearances before embryo transfer affect pregnancy rates in frozen-thawed cycles?
Background The presence of hypoechoic cystic lesions (HCL) within the endometrium has been proposed as a potential factor influencing implantation and pregnancy outcomes during fro...