PLoS ONE
Articles in this Issue
A pilot study on the acoustic effects of a pseudo-palatal plate on speech: Implications for articulatory rehabilitation devices
Intraoral palatal plates used in electropalatography (EPG) and tongue-interface systems are designed to monitor articulatory movement with minimal disruption to speech. However, their presence may sub...
Impact of postoperative macular comorbidity on visual outcomes after Descemet’s membrane endothelial keratoplasty: A multicenter analysis
The aim of this study was to identify the clinical factors associated with postoperative visual acuity following Descemet’s membrane endothelial keratoplasty (DMEK), with emphasis on the impact of mac...
Association between dietary pattern, atherogenic index of plasma, and cardiovascular disease risk factors amongst adults: A cross-sectional cohort-based study
Background and aims This study aims to examine the association between dietary patterns, the atherogenic index of plasma (AIP), and cardiovascular risk factors in adults aged 40–70...
MEPs elicited by multidirectional rotational-field TMS show marked differences compared to unidirectional Figure-of-8 and H7 coils
Unidirectional transcranial magnetic stimulation (udTMS; e.g., via Figure-of-8 coil) depolarizes mainly neurons whose axonal orientation aligns with the direction of the induced electric field. A nove...
Polarization-aware UAV deployment for reliable MIMO communication in forested environments
Unmanned Aerial Vehicles (UAVs) equipped with Multiple-Input Multiple-Output (MIMO) communication systems are increasingly deployed to restore or extend connectivity in forested and remote regions whe...
Interpretable machine learning for chronic kidney disease prediction: Insights from SHAP and LIME analyses
Chronic kidney disease (CKD) is a progressive condition requiring early detection for optimal patient outcomes. This study developed an interpretable machine learning framework using XGBoost with SHap...
A novel approach to managing uncertainty in risk assessment using integrated z-numbers and intuitionistic fuzzy sets: A case study on LPG spherical tanks
Accurate risk assessment in industrial systems is frequently challenged by uncertainty in expert judgments and system behavior. This study proposes a novel approach that integrates Intuitionistic Z-Nu...
Response of mid-lactation primiparous Holstein cows to the supplementation of rumen-protected methionine during the summer
This study aimed to evaluate the effects of rumen-protected methionine (RPM) supplementation on productive and physiological responses of primiparous Holstein cows during summer. We hypothesized that...
Immunoinformatics-driven design of multi-epitope vaccine targeting antibiotic-resistant Salmonella typhimurium
Salmonella typhimurium , a Gram-negative bacterium, is a significant cause of gastroenteritis worldwide, with outbreaks occurring in diverse regions. Despite its global impact, the...
Can policy participation behavior improve the production efficiency of grassland and animal husbandry: A test based on the threshold effect perceived by herdsmen
Based on survey data from 536 pastoral households in Inner Mongolia, this study employs the Propensity Score Matching (PSM) method to estimate the Average Treatment Effect on the Treated (ATT) of herd...
Irritancy and spatial repellency efficacy of repellent-treated fabrics against Aedes aegypti (L.) (Diptera: Culicidae) in an excito-repellency system
Mosquito-borne diseases remain a major public health challenge, driving the need for affordable and scalable vector control tools. In this study, an excito-repellency system was used to evaluate the c...
Prolonged hospital stays and associated factors among hyperglycemic crisis patients admitted to public hospitals in Ethiopia: A prospective observational study
Background A hyperglycemic crisis represents a critical metabolic emergency with potentially fatal consequences and significant health complications. These crises account for appro...
Design and implementation of a comprehensive management platform for drilling engineering
To enhance the efficiency, safety, and data accuracy of drilling engineering, this study developed an integrated business management platform for drilling engineering grassroots units based on the Bus...
Expression of Concern: A practical approach for colorectal cancer diagnosis based on machine learning
Evaluation of usability and acceptability of a Peruvian telemental health service for early assessment among vulnerable occupational workers: Mixed-method study with a user-centered design approach
Background The COVID-19 pandemic marked an increase in depressive, anxiety, and post-traumatic stress disorder symptoms, more specifically among healthcare workers, teachers, and p...
Bacterial isolates and antimicrobial susceptibility profiles of pediatric meningitis at comprehensive specialized hospitals in Bahir Dar, Northwest Ethiopia
Bacterial meningitis remains a major cause of morbidity and mortality among children in low-resource settings. Delayed diagnosis and antimicrobial resistance complicate effective management, and recen...
A phase I clinical trial to evaluate the tolerability and safety of an allogeneic iPSC-derived iNKT cell and α-GalCer-pulsed autologous DC combination therapy for patients with recurrent and advanced head and neck cancer: A study protocol
Natural killer T (NKT) cells show intense tumor-killing activity through direct and indirect pathways. However, humans have less than 0.01% of NKT cells in the peripheral blood, making it difficult to...
Beyond the transcript: Chromatin implications in trans-splicing in Trypanosomatids
Trypanosoma cruzi, Trypanosoma brucei and Leishmania major , usually known as TriTryps, are the causal agents of animal and human sickness,...
Cultural and linguistic responsiveness in long-term care: A scoping review protocol on programs for residents and staff
Background The demographic landscape of Western countries has shifted to a more diverse one. Along with the trend of an aging population, a new problem has emerged, which is the in...
Associations of body fat percentage with C-reactive protein levels in Canadian adults with and without osteoarthritis: Findings from the Canadian Longitudinal Study on Aging (CLSA)
Objectives Determine the cross-sectional associations of serum inflammation with body composition and physical capacity in Canadian adults with/without osteoarthritis (OA) and mult...
Expression of Concern: Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Neoangiogenesis via VEGF/VEGFR-2 Signaling Pathway
Extension of Regression Discontinuity Designs (RDD) to evaluate time effects – A quasi-experimental approach using the data from the new form of care “Integrated cross-sectoral psycho-oncology (nFC- isPO)”
Objective Randomised controlled trials (RCTs) are considered the gold standard in clinical research. However, randomization isn’t always feasible, e.g., due to ethical consideratio...
Identification and validation of genes encoding humoral specificity for the chemical allergen toluene diisocyanate
A panel of hybridomas specific for different isomers of toluene diisocyanate (TDI), a cross‑linking chemical used in polyurethane production, has been previously described. These hybridomas were origi...
Cumulative average triglyceride glucose-waist height index and incident cardiovascular disease in middle-aged and older adults: A nationwide cohort study from the china health and retirement longitudinal study
Background Insulin resistance (IR) is a significant risk factor for cardiovascular disease (CVD), yet practical biomarkers for long-term IR assessment are limited. The triglyceride...
Logarithmically transformed lactate-to-hemoglobin ratio demonstrates a threshold effect on 28-day mortality in sepsis: Analysis of the MIMIC-IV database
Objective To investigate the association between logarithmically transformed lactate-to-hemoglobin ratio (Ln_LHR) and 28-day mortality in sepsis patients, addressing the critical n...