PLoS ONE
Articles in this Issue
Hand grip strength and cognitive dysfunction amongst older Africans in Nigeria
Background The relationship between physical and cognitive health among Africans, known for a rising incidence of frailty, cardiometabolic, and cognitive disorders, is unclear. We...
Evaluation of the mechanism underlying melatonin action in cholestatic liver disease treatment via network pharmacology, molecular docking, and in vivo experiments
The aim of this study was to investigate the mechanism underlying the action of melatonin (MT) in treating cholestatic liver disease. Melatonin and therapeutic targets for cholestatic liver disease we...
The problem is escalating: Barriers faced by medical students in conducting research; A scoping literature review
Background Research is a cornerstone of medical education, equipping future healthcare professionals with critical thinking skills and the ability to apply evidence-based practices...
Prevalence and factors associated with comorbidities in Iranian patients with type 2 diabetes: A national study
Introduction Type 2 diabetes (T2DM) is often accompanied by comorbidities such as hypertension (HTN), cardiovascular disease (CVD), and chronic kidney disease (CKD), which increase...
Critical node identification and resilience analysis against cascading failures
Ensuring the robustness and resilience of critical infrastructure networks such as transportation and energy systems is a core security challenge for modern societies. Vulnerabilities in these network...
Validating the effectiveness of an AI algorithm for pulmonary tuberculosis screening using chest X-ray: Retrospective study and test accuracy with localizer images of the chest CT
Introduction China accounted for 6.8% of global TB cases, and most patients are first diagnosed in general hospitals where chest X-rays (CXR) are widely used for early TB detection...
Determinants of dairy products purchase decisions among polish doctors: A gender-based analysis
The study aimed to address a research gap by identifying the factors that influence the purchasing decisions of individual Polish doctors in the dairy products market, with gender as a demographic var...
Smoking among adolescents in Jordan: Prevalence, associated factors, and its relation to mental health outcomes
Purpose This study aimed to explore the prevalence of various forms of smoking among adolescents in Jordan, identify associated factors, and examine their relationships with mental...
Hepatitis B immunity and vaccine completion among adults at increased risk for hepatitis B infection in Zambia
Background Because of its low cost and lasting effects, hepatitis B virus (HBV) vaccination of adults in Africa could significantly contribute to viral elimination. Among at-risk a...
Effect of formic acid treatment on Apis mellifera foraging behavior using nanopore metabarcoding technologies
The Western honeybee ( Apis mellifera ) is a crucial contributor to worldwide agriculture and ecological health but is experiencing wide population declines lin...
A comparative analysis of vibrational spectra for odorant classification
The olfactory characteristics of flowers have diverse biological and industrial applications. The physicochemical properties of odorants can reveal information about the molecules responsible for a fl...
Bangla MedER: Multi-BERT ensemble approach for the recognition of Bangla medical entity
Medical Entity Recognition (MedER) is an essential NLP task for extracting meaningful entities from the medical corpus. Nowadays, MedER-based research outcomes can remarkably contribute to the develop...
An improved crayfish optimization algorithm for solving engineering optimization problems
By emulating crayfish behaviors such as social foraging, rapid retreat from threats, and adaptive sensing, the Crayfish Optimization Algorithm (COA) achieves a dynamic balance between global search an...
Effect of taxonomy and feeding guilds on waterbirds of the Southern Caspian Sea, Iran
This study measured the concentrations of arsenic (As), cadmium (Cd), chromium (Cr), iron (Fe), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn) in the secondary flight feathers of waterbirds win...
Exploring the drivers of price variation in orthopaedic radical bone tumor resection: A nationwide database study
Background Radical resection of bone tumors is a clinically effective but costly procedure. Despite the implementation of federal price transparency mandates, little is known about...
Temporal dynamics and functional annotation of transcriptome rhythmicity in HEK293T cells
The endogenous circadian clock drives rhythmic processes in nearly all human cells; however, the temporal organization of the transcriptome in HEK293T cells, a widely used cell line, remains incomplet...
Study protocol for a randomized clinical pilot trial investigating feasibility and efficacy of augmenting a virtual reality-assisted intervention targeting auditory verbal hallucinations with biofeedback: The Neuro-VR study
Introduction Auditory Verbal Hallucinations (AVH) are among the most frequent and severe symptoms in schizophrenia and related psychotic disorders. Virtual Reality (VR)-assisted in...
Urban–rural transportation accessibility: A novel geographical indicator for characterizing urban–rural integration
The literature on urban–rural integration lacks not only a geographic indicator that incorporates geographical characteristics (e.g., location, topography, and road infrastructure) to characterize urb...
The association between epicardial adipose tissue thickness and diabetes mellitus, hyperlipidemia, hepatosteatosis, pancreatic steatosis and pancreatitis
Background Epicardial adipose tissue (EAT) is associated with cardiometabolic disorders such as diabetes mellitus (DM), hyperlipidemia, and nonalcoholic fatty liver disease. Howeve...
Second-dose measles vaccination coverage and associated factors among children aged 19 to 35 months in Debre Birhan city, Ethiopia, 2024: A community-based cross-sectional study
Background Achieving high coverage of both measles vaccine doses is essential for herd immunity. Despite high first-dose coverage, measles outbreaks persist in Debre Birhan City, E...
Predictive modeling of sugar beet bolting via vernalization-intensity model and resilience assessment in diverse autumn cultivation environments
Climate change and increasing pressure on water resources have renewed interest in autumn cultivation of sugar beet, a practice that benefits from seasonal precipitation and reduces dependence on irri...
Two decades of skeletal density decline in Pocillopora spp. corals in the Mexican Pacific Ocean: Insight into a tropical eastern Pacific acidification scenario?
Corals demonstrate vulnerability to environmental changes, exhibiting the capacity to substantially modify coral calcification. In this study, we estimated declines in the density of...
Genotypic variability and trait associations for cold stress tolerance in cultivated chickpea (Cicer arietinum L.) during the reproductive stage
Chickpea ( Cicer arietinum L.), a major winter legume in northern South Asia and Australia, frequently encounters low temperatures (0–15 °C) during reproduction...
Assessing the biopotency of the rAAV9 vector In Vitro
The potency assay is critical to ensure the effectiveness and consistency of recombinant Adeno-associated Virus (AAV) gene therapy vectors, especially clinical-grade products. AAV serotype 9 (AAV9), k...
Multilevel determinants of illness since birth among infants aged 5–9 weeks in Ethiopia: Evidence from the 6-week follow-up of the PMA-ethiopia longitudinal survey (2021–2023)
Background Infant illness in the early weeks of life remains a major public health concern in Ethiopia, contributing to neonatal and infant morbidity and mortality. Identifying ind...