PLoS ONE
Articles in this Issue
Development of a novel konjac glucomannan/soy protein isolate/fatty acid composite film: Insights into the structure, properties and interaction mechanism
The preparation, structural characterization and properties analysis of novel konjac glucomannan (KGM)/soy protein isolate (SPI)/fatty acid (KS-FA) films were carried out in this paper. KS-FA films ex...
The effect of a familiarization critical speed testing session on critical speed determination during treadmill running
Background The effect of familiarization with the critical speed (CS) testing process on the outcome of CS tests has yet to be determined....
Enhanced extractive text summarization framework for low-resourced Urdu language
This era has witnessed an enormous increase in textual corpus available in digital form. Therefore, an intelligent mechanism is required to extract the essential information. This task is performed us...
Usual gait speed is inversely associated with depression in middle-aged and older adults: A cross-sectional study in Korea
Background Depression is a serious mental disorder and leading cause of suicide. This study investigated the association between usual gait speed (UGS) and risk of depression....
A hybrid framework for notebook market analysis: Integrating social media sentiment mining with expert knowledge for feature prioritization
The increasing complexity of consumer preferences in the notebook market requires advanced methodologies to effectively analyze user sentiments and prioritize product features for strategic decision-m...
Exploring heterogeneity in treatment effects: The impact and interaction of asset-based wealth and mass azithromycin distribution on child mortality
Objective To examine how child mortality among children aged 1–59 months varies by asset-based wealth status in rural Burkina Faso, and to assess the interaction between mass azith...
Calibration of discrete element parameters for cohesive soils at different moisture contents
To obtain discrete element method simulation parameters for cohesive soil during the scrapping process of loaders, this paper calibrates parameters of cohesive soil with different moisture contents ba...
Genetic analysis of drought and heat tolerance combined with Striga hermonthica resistance in tropical maize (Zea mays)
The occurrence of combined biotic and abiotic stresses with more damaging effect is worsening in maize production fields in SSA due to climate change. The development of multiple stress tolerant maize...
Validation of an agent-based model for cell interactions in a microfluidic chip
Objectives: Microfluidic cell Co-Culture, Tissue Co-Culture and Organ-on-Chip (OoC) technologies enable modeling of tissues and organs in vitro, facilitating cell-environment inter...
Maternal and demographic factors influencing oral Candida albicans in infants: A stratified analysis using a novel partial linear semiparametric mixed-effects model
Candida albicans , a pathogenic fungus implicated in early childhood caries (ECC), plays a crucial role in oral health. While its colonization usually begins at birth, the extent o...
Effect of race and sex on lupus diagnosis in primary care: A randomized factorial survey study
Background Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune rheumatic disease whose epidemiology and clinical prognosis vary by race and sex. Observed disparities i...
Transmission matrix of a multimode fiber: In-line vs off-axis holography
Multimode fibers (MMFs) hold great promise for a variety of imaging applications. However, controlling the complex propagation of light through thousands of modes in MMFs remains a challenging task. T...
IL-22 inhibits ferroptosis and attenuates ischemia-reperfusion-induced acute kidney injury: Association with activation of the P62-Keap1-Nrf2 signaling pathway
Acute kidney injury (AKI) remains a major clinical challenge due to its high morbidity and mortality, with ischemia-reperfusion injury (IRI) as one of its primary causes. Severe IRI-associated AKI (IR...
Bronze Age non-elite mobility in Denmark examined through a new human-based bioavailable strontium isotope range
Strontium isotope analysis is now a key method for investigating ancient human mobility, leading to a rapid expansion of available ⁸⁷Sr/⁸⁶Sr datasets. Owing to the relatively homogeneous surface geolo...
Development of niosomal nanoparticles loaded with cisplatin and vorinostat combination for cancer therapy
Cisplatin (CIS) remains a cornerstone of chemotherapy but is limited by resistance and systemic toxicity. Combining DNA-damaging agents with epigenetic modulators such as vorinostat (VOR) offers a pro...
Identification of antimicrobial compounds in Dipsacus inermis via phytochemical profiling, in vitro assessment, and advanced computational techniques
Antimicrobial resistance (AMR) poses a major challenge in treating infections such as pneumonia and typhoid fever, necessitating novel therapeutics. Plant-derived natural products provide a promising...
Mapping SBiP1 protein-protein interactions in Symbiodinium microadriaticum CassKB8 using the Yeast Two-Hybrid assay and structural prediction
BiP chaperones are central regulators of protein folding, endoplasmic reticulum homeostasis, and stress response across eukaryotes, but their client networks remain largely uncharacterized in Symbiodi...
Malaria-diabetes comorbidity is linked to higher parasitaemia and enhanced IgG response to malaria vaccine candidate antigens
Background The coexistence of type 2 diabetes mellitus (T2DM) and malaria presents a significant public health concern, particularly in malaria-endemic regions. T2DM’s immunomodula...
Fast decision mechanism for ternary tree partitioning in VVC intra coding
In Versatile Video Coding (VVC), the partition patterns for coding units (CUs) have significant impact on the encoding efficiency. Determining the optimal CU partition is particularly time-consuming d...
Factors influencing the caregiver burden for family caregivers of people with moderate-to-severe dementia: A structural equation modeling analysis
Background Dementia poses an increasingly serious public health challenge worldwide, particularly in China, where home-based care remains the primary form of management. Family car...
Multi-omics analysis reveals STING activation mediates NLRP3-related pyroptosis and exacerbates myocardial ischemia-reperfusion injury
Background Myocardial ischemia-reperfusion injury (I/R) significantly exacerbates cardiomyocyte damage post-recanalization therapy in acute myocardial infarction. Pyroptosis and th...
Data-driven predictive modeling for massive intraoperative blood loss during living donor liver transplantation: Integrating machine learning techniques
Background Massive intraoperative bleeding (IBL) in liver transplantation (LT) poses serious risks and strains healthcare resources necessitating better predictive models for risk...
Measuring and understanding labor exploitation on a sample of workers in the Costa Rican fishing industry
Due to the challenging nature of surveying exploited workers, scholars are often limited in their ability to standardize data collection efforts. Using two samples of survey data from workers in the C...
A qualitative exploration of video-based motor action observation perceptions in patients with chronic low back pain and asymptomatic participants: An interpretative phenomenological analysis
Background Video-based action observation (AO) of exercise/motor-action content is increasingly delivered via social media. This expands reach and ecological validity but may shape...
Systematic review of lung function assessment among youth and young adults e-cigarette users: Current tools and emerging methods
Introduction This review focuses on the need to identify the lung function assessment tools used for young EC users. The objectives are to examine the current and emerging methods...