PLoS ONE
Articles in this Issue
The identity blueprint: Decoding the professional identity of Basic Sciences Medical Teachers in Pakistan by developing and pilot testing a questionnaire
Introduction The goal of the current study was to identify factors forming the professional identity of medical teachers teaching basic health sciences by developing and validating...
Assessing knowledge levels on coronavirus disease (COVID-19) among community members: The influence of community engagement efforts in Seke district, Zimbabwe: A cross-sectional study
Introduction The COVID-19 pandemic posed significant public health challenges globally, with effective containment relying heavily on community knowledge and engagement. This study...
Anticonvulsant effects of novel and repurposed drugs on docetaxel-induced neuropathy in C. elegans
Chemotherapeutic agents used for most common cancers are frequently associated with neurotoxicity, which often include debilitating side effects such as seizures. Docetaxel, one of the most widely and...
Nanophotonic perfect absorber with ultra-broadband terahertz-to-infrared response via hybrid-material design for advanced optical sensing
The terahertz (THz) frequency range has gained significant attention in recent years, particularly for applications in biological diagnostics, remote sensing, security systems, and wireless communicat...
Salt loading as a promising approach to study the dopaminergic phenotype of neurons of the supraoptic nucleus in mice
Until the beginning of this century, neurons of the supraoptic nucleus (SON) were repeatedly shown to express tyrosine hydroxylase (TH) in salt loaded rats. However, its role remains unsolved due to m...
Workforce, succession planning, and optimism for the future among Swiss general practitioners with additional training in complementary medicine in 2016: A nationwide cross-sectional study
The shortage of general practitioners (GPs) and the aging workforce of established GPs in Switzerland are persistent. Furthermore, data on GPs with additional training in complementary medicine (CM) a...
Dispute resolution in China: A test of black's theory of legal behavior
Since its introduction, Black’s theory of legal behavior (BBL) has been widely applied in empirical studies to analyze legal decision-making and dispute resolution. However, its applicability in non-W...
Mechanization-driven farmland consolidation and farm household labor allocation: Evidence from grain producers in Shandong, China
Mechanization-driven farmland consolidation has become a key component of China’s efforts to raise grain productivity and optimize rural labor allocation. We used a survey of 630 grain-producing house...
Design and evaluation of structural risk mitigation measures for transmission lines micro-pile foundations in mountainous region
Influenced by the complex geological conditions in mountainous region, micro-pile foundation for transmission line faces the risk of insufficient bearing performance. It is important to study the risk...
Perceived sound localization abilities in blind individuals
Purpose There is extensive research on sound localization performance of blind individuals in laboratory settings. However, less is known about their spatial hearing experiences in...
Towards triple elimination of HIV, syphilis and HBV mother-to-child transmission: Protocol of a simplified and integrated strategy in Burkina Faso and The Gambia: Protocol for the phase 1 of the TRI-MOM project
Introduction Mother-to-child transmission (MTCT) of HIV, syphilis, and hepatitis B virus (HBV) commonly observed in the WHO African region is associated with excess morbidity and m...
Multi-attention cross-scanning VM-UNet for X-ray welding defect detection of steel pipeline
Welding defect detection of steel pipelines (SPWDD) is critical for ensuring the safe use of oil/gas pipelines. Due to the complex morphology of welding defect X-ray images (WDXI) in steel pipes and t...
An overdispersed count regression model for analyzing road accident fatalities and injuries in Bangladesh
Road traffic accidents (RTAs) continue to be a major global public health issue, particularly in countries with developing road safety infrastructure like Bangladesh, where the road traffic fatality r...
Carbon storage in Sichuan Province (Southwest China) from 1980 to 2050: Spatial-temporal variation, driving factors and future trends
Research on carbon storage is crucial for guiding regional sustainable development. However, Sichuan Province lacks long-term systematic analyses of carbon storage, and the driving mechanisms behind i...
Doing more with less: Genomic quasi-G-primes differentiate septic from healthy patients
Sepsis is a life-threatening state of disseminated infection, and treatment requires knowledge of the organism responsible. The gold standard for sepsis diagnosis is blood culture, which requires days...
Machine learning-inspired similarity measure to forecast M&A from patent data
Defining and finalizing Mergers and Acquisitions (M&A) requires complex human skills, which makes it very hard to automatically find the best partner or predict which firms will make a deal. In th...
Psychometric properties of the Adult Primary Care Assessment Tool Short form (PCAT-S) among high-risk patients in Australian general practice
Introduction The Primary Care Assessment Tool (PCAT) is designed to assess a patient’s experience with primary care across various core and ancillary domains, including First conta...
MLND-IU: A multi-stage detection model of subcentimeter lung nodule with improved U-Net++
To address the challenges of high miss rates in subcentimeter nodules, false positives caused by vascular adhesion, and insufficient multi-scale feature fusion in lung CT analysis, a multi-stage detec...
RAF1 as a standalone therapeutic target in KRAS-driven lung adenocarcinoma: No added efficacy from co-targeting ARAF, EGFR, or DDR1
Background/objectives KRAS-mutant lung adenocarcinoma remains without effective targeted therapies for most patients, particularly those with non-G12C allele...
Genetic ablation of interleukin-17A augments fibrosis in a mouse model of cholestatic liver injury
Aim The underlying mechanisms contributing to cholestatic liver injury remain unclear. The pro-inflammatory leukocyte-restricted cytokine interleukin-17A (IL-17A) has been implicat...
A multifaceted analysis of OTUD5 integrated MAVS in innate immunity of Primary Biliary Cholangitis
Background Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by cholestasis caused by intrahepatic small bile duct injury. Promoting the molecul...
Eccentric cycling is superior to standard rehabilitation for Post-ICU recovery in COVID-19 survivors
Background The COVID-19 pandemic left numerous patients with post-intensive care syndrome (PICS) that resulted in prolonged physical and health impairment. Compared to standard reh...
Screening a library of antibacterial compounds leads to discovery of novel inhibitors for Neisseria gonorrhoeae and Chlamydia trachomatis
Chlamydia trachomatis and Neisseria gonorrhoeae were the most common bacteria causing sexually transmitted infections (STIs) in 2020, with 2...
Monte Carlo dosimetric characterization of the IRAsource high dose rate Iridium-192 brachytherapy source: Comparison with the mHDR-v2r model
The aim of this study was to evaluate the dosimetric characteristics of an IRAsource brachytherapy source using Monte Carlo simulations incorporating source electron effects. The dose rate constant, r...
Activity driven sleep dynamics: A conceptual modeling study
The sleep state is traditionally defined as global, involving the entire body. Accordingly, a two-process mathematical model of the switch between sleep and wakefulness was proposed by Borbely more th...