PLoS ONE
Articles in this Issue
Socioeconomic status and depressive symptoms among older adults in China: The mediating role of cognitive function, lifestyle and social participation
Introduction Socioeconomic status (SES) is a key risk factor for depression in older adults, while cognitive function, lifestyle and social participation also have an impact on dep...
Socio-demographic and environmental determinants of camel mortality in Somaliland’s nomadic communities: A negative binomial regression analysis of the 2020 demographic and health survey
This study presents the first comprehensive quantitative assessment of the socio-demographic and environmental determinants of camel mortality in Somaliland’s nomadic communities, leveraging household...
Modeling viral shedding and symptom outcomes in oseltamivir-treated experimental influenza infection
Influenza remains a global public health concern, and although the antiviral drug oseltamivir is widely used to treat infections, questions regarding its actual antiviral efficacy and clinical benefit...
Comparisons of factors correlated with successful smoking cessation between middle-aged and older smokers
Background As the elderly population expands, smoking cessation becomes increasingly vital due to their heightened risk of adverse health effects. This study investigated the facto...
Environmental influences on community participation among people with multiple sclerosis: A mixed methods study
Objective To examine the influence of environmental factors (EFs) and personal factors (PFs) on community participation among people with multiple sclerosis (PwMS) and identify are...
Validation of visual analogue scales to assess occupational stress compared to the Karasek questionnaire: A cross sectional study
Background The Job Demand-Control-Support (JDCS) model is one of the most important tools for assessing work-related stress. However, its complexity highlights the need for simpler...
How to promote universities’ research and development into green agricultural products – A tripartite evolutionary game analysis
Research into green agricultural products significantly enhances the sustainable development of China’s agriculture. These products ensure food safety, meet quality demands, reduce pollution, and adva...
Coupled pharmacokinetic model unveils drug-drug interactions in plasma concentration
In oral drug pharmacokinetics (PK), drug-drug interactions are inevitable, yet traditional compartmental models struggle to effectively quantify such processes. This study proposes a linearly coupled...
Identifying optimal combination regimens for therapy of Mycobacterium tuberculosis with an algorithmic approach: prospective predictions and validations
Background Mycobacterium tuberculosis resistance to standard-of-care agents is increasing. It is imperative to identify new combination...
Color as physical/conceptual attribute: Color word translation by Chinese postgraduate students
Color words present a persistent translation challenge because they function as both perceptual descriptors and carriers of conceptual meaning, and translators must decide which dimension to foregroun...
Integrated microbiomics and metabolomics analysis reveals distinct profiles in carbapenem-resistant Acinetobacter baumannii and Escherichia coli infections in Pancreatitis-associated sepsis
Background Pancreatitis-associated sepsis (PAS) caused by carbapenem-resistant bacteria poses significant clinical challenges. The objective of this research...
Simulation of liquid hydrocarbon production via n-tetradecane reforming: A renewable energy approach
Considering the current worldwide search for renewable energy, n-tetradecane has attracted attention as a candidate for a hydrogen energy carrier and more sighted for light hydrocarbon within the gaso...
Temporal relationship of suicide-related internet searches and suicide rates in Korea: A prewhitened cross-correlation analysis
Objective Suicide-related internet search patterns may reflect population-level behavioral responses to suicide risk. This study investigated the temporal associations between suic...
A new method of off-site inverse carbon accounting and its application in agriculture carbon measurement
This research introduces an innovative agricultural carbon accounting approach for straw burning that combines stochastic process modeling with LSTM neural networks. Traditional methods face limitatio...
MAGIN-GO: Protein function prediction based on dual graph neural networks and gene ontology structure
Proteins are fundamental to the execution of biological activities, and the accurate prediction of their functions is of paramount importance for protein research. Recent advancements in deep learning...
Correlation between follicular fluid hormonal levels in PCOS women and embryo development in ART cycles
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by ovulatory dysfunction. Fertility outcomes in PCOS patients are often suboptimal, potentially owing to alterations in...
Associations among health literacy, anxiety symptoms, and health-related quality of life in Korean adults: A cross-sectional study with age-stratified analyses
Background Health literacy (HL) is a key determinant of physical and mental health outcomes; however, the relationships among HL, anxiety symptoms, and health-related quality of li...
Regional disparities in subjective wellbeing across Europe: A fuzzy hybrid TOPSIS approach
The study analyses differences in subjective well-being (SWB) across European regions. Through the Fuzzy-Hybrid TOPSIS approach, we analyse SWB at the country and regional levels. Additionally, a quan...
Sex and rank in public service hierarchies: Rank distribution in Ghana’s health and security services
This study analyses leadership patterns in Ghana’s health and security institutions since 1992, with a particular emphasis on the sex composition of senior positions in the Ghana Health Service, the A...
Stakeholder perspectives on depression management: A design thinking exploration for person-centered digital health
Introduction eHealth has the potential for managing depression and enhancing quality of life. Identifying end user needs and employing participatory methodologies that actively eng...
IGM: Integrated Gene-expression Modeling for multi-condition flux-preserving genome-scale metabolic models
Genome-scale metabolic models (GEMs) are powerful tools for studying cellular metabolism, but conventional approaches such as Flux Balance Analysis (FBA) often yield ambiguous results due to the lack...
Voices from the emergency department: A theoretical framework analysis on patient experiences of care in emergency departments of Newfoundland and Labrador, Canada
Background Patient experience in the emergency department (ED) encompasses different aspects of care, such as respect, communication, timeliness, shared decision-making, and care t...
Recycled polymer shot as sustainable additive for concrete: Mechanical, thermal, and environmental assessment
The exponential growth of plastic production has led to a dramatic increase in plastic waste, creating significant environmental and public health challenges. Among the available disposal methods, rec...
Analysis of market equilibrium based on overconfidence behavior of market makers
This paper constructs a theoretical model that includes heterogeneous risk-attitude insider traders (risk-neutral and risk-averse), overconfident market makers, and noise traders. It compares the mode...
Breast cancer inter-image dissimilarity by feature optimization: An application of novel flea optimization algorithm
Background/Objective: Breast cancer is a serious disease that has caused thousands of deaths around the world. According to the American Cancer Society, more than 40,000 women and...