PLoS ONE
Articles in this Issue
CRISPR/Cas9-Mediated Editing in FAD2 Gene to Enhance Oil Quality in Soybean [Glycine max (L.) Merrill]
Conventional soybean oil contains high levels of linoleic acid, which reduces oxidative stability and necessitates hydrogenation, leading to trans-fat formation. In this study, 40 Indian soybean genot...
Spatial distribution and factors associated with co-occurrence of anemia and undernutrition among children aged 6–59 months in East Africa
Background Anemia and undernutrition are major public health concerns affecting child growth, development, and survival, particularly in low-resource settings like East Africa. The...
Assessing allocation bias in stratified clinical trials with multi-component endpoints evaluated using the stratified Wei-Lachin test
Background: A common issue in rare disease stratified clinical trials with multi-component endpoints is allocation bias, as they frequently lack blinding. Allocation bias arises wh...
The effects of problem-based learning (PBL) on undergraduate medical students’ critical thinking and communication skills development: A scoping review across resource-rich and resource-limited settings (2015–2024)
Background Problem-based learning (PBL) is widely recognized as an effective method for enhancing critical thinking and communication skills in medical education. However, in first...
Prevalence and determinants of unintended pregnancy among female sex workers (FSW) in Jashore, Bangladesh
Background Unintended pregnancy among female sex workers (FSW) is a pressing reproductive health concern attributable to risky sexual behaviors, healthcare inequities and poor nego...
Multi-epitope vaccine design against Monkeypox virus: An immunoinformatics approach
Background The recent outbreak of the Monkeypox virus (MPXV) across multiple regions has highlighted the need for effective vaccine. This study employed an in-silico immunoinformat...
Concurrent depression and anxiety in women undergoing additional diagnostic procedures due to positive screening for cervical cancer
Introduction Undergoing additional diagnostic procedures due to a positive cervical cancer screening in women can lead to psychosocial burden. This study investigated the co-occurr...
Use as directed? A comparison of software tools intended to check rigor and transparency of published work
The causes of the reproducibility crisis include lack of standardization and transparency in scientific reporting. Checklists such as ARRIVE and CONSORT seek to improve transparency, but they are not...
Enhancing rainfall estimation accuracy with machine learning, cloud masking, and multi-source data: A case study of four coastal provinces in central Vietnam
This study develops the LGBM-3SC-CF product, a machine learning framework that integrates multi-source data (Himawari-8, ERA5, ASTERDEM, and rain gauge) to significantly improve rainfall classificatio...
Mapping disparities in diabetic eye exam adherence using geographic information systems
Background Diabetic retinopathy is a leading cause of preventable vision loss in adults, and timely retinal screening is essential for early detection and intervention. However, ad...
Mapping the evolution of cross-Strait relations via global news big data (2014–2023): An analysis integrating GDELT and machine learning
This study investigates global news media representations of cross-Strait relations from 2014 to 2023 using the GDELT database, framed within the mediatization of politics. Combining large-scale event...
Temperature sensing based on slow light via stimulated Brillouin scattering in M-shaped few-mode fiber
This study investigates temperature sensing based on slow light generation via stimulated Brillouin scattering in an M-shaped few-mode fiber. The temperature-dependent properties of four optical modes...
Search model based on Kalman Filter and Monte Carlo simulation
In the search and rescue operation of the submersible, to better search for the missing or faulty submersible, taking the marine environment simulated by the HYCOM model as the sample, it is necessary...
Lifestyle and environmental risk factors for myopia in children: Evidence from a large-scale cross-sectional study in Shandong, China
Myopia has emerged as a pressing global public health issue, with a particularly sharp rise observed among school-aged children. This period represents a critical window for implementing timely, evide...
Visual assessment of antimicrobial medicine packaging and labeling quality in pharmacies of Ho Municipality, Ghana
Background Substandard and falsified antimicrobials threaten public health due to their role in resistance development. Pharmacies, as key access points for antimicrobials, can pla...
Improving Greater Caribbean manatee vocalization detection across habitats using neural networks
The detection and classification of Greater Caribbean manatee vocalizations ( Trichechus manatus manatus ) present unique challenges due to the complexities of...
Effects of matcha green tea on the pharmacokinetics of nadolol in rats
The concurrent use of herbal dietary supplements with prescription medications raises safety concerns due to the potential for clinically significant interactions. Matcha, a shade-grown green tea cons...
Chronic intestinal immune activation reveals separable impacts of inflammation and barrier loss on hallmarks of ageing
Inflammaging is considered a driver of age-associated pathology across tissues. Similarly, intestinal permeability is a feature of ageing and underlies a range of inflammatory and age-related diseases...
Utility of a freehand frameless navigation system in computed tomography-assisted ventral bulla osteotomy for otitis media in calves
Ventral bulla osteotomy has not been widely adopted for treating otitis media in calves due to its prolonged surgical duration (>1 h), high surgical invasiveness, and challenges in application for...
The post-activation performance enhancement effect of different plyometric training modalities on short-distance sprinting: An acute randomized crossover study
Objective This study aimed to investigate the effects of different plyometric training modalities [vertical jump plyometric training (VJ-PT), horizontal jump plyometric training (H...
ACE-031, a soluble activin type IIB receptor, increases muscle mass and strength in the common marmoset (Callithrix jacchus)
Pharmacological blockade of ligands for the activin receptor type IIB (ActRIIB) e.g., myostatin and activin A is associated with improvements in murine skeletal muscle mass and function. The efficacy...
What affects rural households’ entrepreneurial performance: Formal or informal finance availability?
This study explores the role of financial availability in the growth and development of rural household entrepreneurship, particularly beyond the start-up phase. Focusing on entrepreneurial rural hous...
Development of a cAMP biosensor-based assay for measuring serum bioactive concentrations of FSH
Follicle-stimulating hormone (FSH) plays a pivotal role in reproductive physiology and is increasingly recognized for its involvement in the extragonadal system. The biological activity of FSH, which...
A scoping review protocol of existing body image guidelines for parents of youth
Body image concerns are commonly experienced by youth in sport and contribute to worse sport experiences and dropout. Parents are positioned to ensure the sport environment is safe and positive for th...
L‒asparaginase activity in some endophytic fungi: Glutaminase‒free and low urease co‒activities
In this study, L‒asparaginase production in several endophytic fungi was evaluated along with their L‒glutaminase and urease co-activities. The effect of L‒asparagine and different culture media on L-...