PLoS ONE
Articles in this Issue
Justifying model complexity: Evaluating transfer learning against classical models for intraoperative nociception monitoring under anesthesia
Background Accurate intraoperative detection of nociceptive events is essential for optimizing analgesic administration and improving postoperative outcomes. Although deep learning...
Use of mannans as an elicitor of the defense response on Vitis vinifera against fungi causing Grapevine Trunk Diseases
Grapevine Trunk Diseases (GTDs) are caused by phytopathogenic fungi that compromise grapevine productivity and wine quality. Most GTDs preventive treatments are chemical-based and environmentally harm...
CD47 blockade (ALX301) enhances immunoradiotherapy response in HPV negative head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is a significant cause of morbidity and mortality worldwide, with limited treatment options for patients with locally advanced disease. CD47 immune checkp...
Outliers (typically) cannot cause type I errors in one-sample/paired t-tests
The presence of outlying data points can have a significant impact on statistical modeling and significance testing. In the specific context of one-sample t-tests, prior studies have shown (primarily...
Expression of Concern: Research on the aesthetic sensitivity evaluation of tourism mascots based on semantic differential method
Integrative computational, synthetic, experimental evaluation of targeted inhibitors against matrix metalloproteinase-9: Toward precision modulation of proteolytic activity
Matrix metalloproteinase-9 (MMP-9) is a zinc-dependent enzyme that degrades the extracellular matrix and is involved in various diseases, including rheumatoid arthritis, atherosclerosis, tumor invasio...
96 sample parallel acoustic fragmentation for high throughput next generation sequencing library preparation
Random, unbiased fragmentation of genomic DNA is necessary for next generation sequencing (NGS), yet the process of DNA fragmentation is still a bottleneck in NGS pipelines. A technology that increase...
Longevity of different in-office treatments for dentin hypersensitivity: A 6-month randomized and parallel clinical trial
This longitudinal, randomized, parallel-design clinical trial aimed to evaluate the long-term effectiveness of different in-office treatments for dentin hypersensitivity (DH) over a 6-month period. A...
Correction: Akt3 links mitochondrial function to the regulation of Aurora B and mitotic fidelity
The JAK1-STAT1 signaling pathway triggers inflammation responses in chronic obstructive sleep apnea rat model
Background Chronic obstructive sleep apnea (OSA) drives systemic inflammation; the role of the JAK1-STAT1 pathway is unclear....
Persistence of the hepatic benefits of high-intensity interval training (HIIT) during detraining despite body weight regain in mice
High-intensity interval training (HIIT) is an effective intervention for improving metabolic health and mitigating metabolic dysfunction-associated steatotic liver disease (MASLD). Nonetheless, the st...
Image-based machine learning models for customized soil moisture management
Crop growth can vary even under the same cultivation conditions, highlighting the limitations of conventional smart farming systems that apply uniform treatments to all crops. These average-based appr...
Assessing the role of peer education in improving clinical and patient-reported outcomes in adults with chronic kidney disease: A scoping review protocol
Purpose This paper describes a protocol for a scoping review examining the role of peer education programs for people with chronic kidney disease across diverse healthcare settings...
Neighborhood perceivable graph neural network for relational heterogeneous Twitter bot detection
Malicious bots undermine the integrity and safety of online social platforms, making their detection an urgent priority. This work aims to address the limitations of existing GNN-based bot detection a...
Study on electromagnetic characteristics of cylindrical hole defect in variable parameter traction motor shaft based on eddy current effect
Detecting common cylindrical hole defects (corrosion defects) in locomotive traction motor shafts is essential to ensure equipment reliability and safety. This paper conducts an in-depth study of rota...
Intralesional bevacizumab as an adjuvant approach to recurrent respiratory papillomatosis: A prospective study on different treatment protocols
Objectives Adjuvant intralesional administration of bevacizumab has shown promising effects in the management of recurrent respiratory papillomatosis (RRP). However, the optimal th...
Chrysin ameliorates methotrexate-induced hippocampal neurogenesis impairment by suppressing of oxidative stress and upregulating antioxidant enzyme activity in rodents
Methotrexate (MTX) is used in treating several malignancies. However, MTX neurotoxicity remains a significant clinical side effect, leading to cell division malformation, and neurogenesis impairment....
Early diagnosis of Alzheimer’s Disease: Graph theoretical analysis of cerebellar network features based on 18F-AV45 PET
Pathological and neuroimaging changes in the cerebellum of Alzheimer’s disease (AD) patients have been well documented. However, the changes in cerebellar amyloid plaque deposition connectivity networ...
Correction: Analyzing Riemann-Liouville constraints in second-order Lagrangian fractional electrodynamic models
Correction: Changes in pneumococcal vaccine coverage in the Canadian Longitudinal Study on Aging (CLSA): An analysis based on the 2018–2021 follow-up 2 survey
Editorial Note: Analysis of the high-quality development path of China’s tea export
Development of a Flex-Seq SNP panel for raspberry (Rubus idaeus L.) and validation through linkage map construction and identification of QTL for several traits of agronomic importance to raspberry breeding
High-throughput and reproducible genotyping platforms are critical for advancing genetic research and breeding in horticultural crops. Here, the development and validation of a custom single nucleotid...
Exploring psychiatrists’ perspectives on supporting parents with mental health Challenges: A mixed-methods study
Background Parenting responsibilities can be particularly challenging for patients receiving mental health services, often resulting in a range of negative impacts on children. Inc...
Implementation research to scale up the women and infants integrated interventions for growth study (WINGS) in Himachal Pradesh: Protocol for a quasi-experimental, mixed-methods study
Background Maternal undernutrition, anaemia, low birthweight (LBW) and childhood stunting remain major public health challenges in India. Evidence from the Women and Infants Integr...
Development of serologic diagnostic test based on in silico predicted synthetic peptides for Brucella canis in dogs
Serologic diagnosis of canine brucellosis caused by Brucella canis remains quite challenging since the currently available methods have considerable limitations...