PLoS ONE
Articles in this Issue
Expression of Concern: Comparative efficacy of different antihypertensive drug classes for stroke prevention: A network meta-analysis of randomized controlled trials
Molecular characterization of hepatitis B virus genotypes A and D among inmates and blood donors in Northeastern Kenya
Introduction Hepatitis B virus (HBV) persists as a major global public health burden, with hyperendemic prevalence in sub-Saharan Africa. Populations with elevated exposure to perc...
Highly efficient production of transgenic rats with long DNA insertions using piggyBac transposase mRNA and piezo-assisted microinjection
In the conventional method of producing transgenic (Tg) animals, donor DNA is microinjected into the pronuclei of zygotes using a sharp glass needle. However, this approach is generally inefficient as...
Hyper-MDR: An open-world multimodal reasoning framework based on dynamic hypergraph and meta-strategy optimization
Open-world object detection (OWOD) has become a crucial paradigm for advancing intelligent perception systems, as it requires not only accurate recognition of known categories but also autonomous disc...
Elucidating key targets and mechanisms of diethyl phthalate-induced colorectal cancer through network toxicology and molecular docking
Background Diethyl phthalate (DEP), a widely used plasticizer with endocrine-disrupting properties, has raised concerns regarding its potential carcinogenic effects. However, its p...
Expression of Concern: Multi-convolutional neural networks for cotton disease detection using synergistic deep learning paradigm
Correction: Study on the mechanism of mining-induced pressure mitigation in gangue backfill mining and the sensitivity analysis of main controlling factors
Enhanced grain quality of malt barley (Hordeum distichon L.) in response to mixed use of organic compost and mineral nitrogen rates
Declining soil fertility status and poor agronomic management practices are major factors of declining quality for malt barley in the Ethiopian highland area, particularly in the study area. To addres...
Cultural adaptation and content validation of the WHO BeSD framework for HPV vaccination in Pakistan: A two-phase Delphi and cognitive interview study
Background The BeSD Framework (Behavioral and Social Drivers of Vaccination), developed by the World Health Organization, provides a structured approach to understanding the behavi...
Patients’ needs and preferences in developing Art-Based Learning in outpatient palliative cancer care: A qualitative study
Purpose Art-Based Learning (ABL), an art pedagogical practice, may assist cancer patients by providing a meaningful experience through art viewing. However, little is known about w...
Beyond automation: How IT professionals utilize the invisible AI arm?
Artificial intelligence (AI) is transforming task optimization across many occupations, particularly within the IT sector. Understanding how IT professionals use AI is crucial for establishing benchma...
Methodological quality and reporting characteristics of anthropometric measurements in studies assessing the nutritional status of children in Ethiopia: A scoping review
Background Accurate anthropometric data is essential for assessing nutritional status. To ensure data quality, careful planning of instruments, training and supervision of enumerat...
Editorial Note: Profit distribution mechanism of agricultural supply chain based on fair entropy
Correction: Who presents the greatest challenge in intellectual disability research- participants or health and research professionals?
Improving access to free school meals: Evaluating the implementation of free school meal auto-enrolment processes
To receive benefits-related free school meals in England, households must currently have an annual household income of less than £7,400 (before any benefits-related income), and parents must submit an...
The immunopathological crosstalk of diabetic periodontitis: Single-cell insights into monocyte dysregulation
Periodontitis (PD) and type 2 diabetes mellitus (DM) are bidirectionally associated through shared chronic inflammatory mechanisms. Although monocytes serve as central immune mediators in both patholo...
Cooling and heating season performance of an open counterflow heat-source tower heat pump system in high-humidity climates: An experimental and numerical study
The cooling and heating season performance of an open counterflow heat-source tower heat pump (HTHP) system in high-humidity climates is investigated through an integrated experimental and numerical s...
Local and global mortality experience: A novel hierarchical model for regional mortality risk
Accurate mortality risk assessment is critical for decision-making in life insurance, healthcare, and public policy. Regional variability in mortality, driven by diverse local factors and inconsistent...
Identification of SORCS1 as a candidate gene associated with canine behavioral traits: Insights from guide dog training outcomes
Although genetic factors contribute to behavioral variation in working dogs, the underlying molecular determinants remain poorly understood. The sortilin-related VPS10 domain–conta...
Association between cervical conization and pregnancy outcomes: A nationwide population-based cohort study
Cervical conization is the standard treatment for cervical intraepithelial neoplasia. However, its effects on pregnancy outcomes remain controversial. Using data from the Korean National Health Insura...
Modeling physics data with the generalized Marshall-Olkin Kumaraswamy distribution
In this paper, a new distribution defined on a bounded interval is introduced, and its main properties, such as moments, Lorenz, and Bonferroni curves, are examined. The unknown parameters of the prop...
The impact of lifestyle restrictions on memory in older adults
Engagement in a variety of lifestyle activities, such as intellectual stimulation, social interaction, and physical exercise, is thought to be a key contributor to cognitive reserve, helping the brain...
Hurricane disturbance results in positive effects on tropical stream meiofauna abundance and richness
Hurricanes are major natural disturbances that significantly influence tropical ecosystems. While most research focuses on large-bodied organisms, understanding the impact of hurricanes on small-bodie...
Correction: Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells
A live cell biosensor protocol for high-resolution screening of therapy-resistant cancer cells
The Genetically Encoded Death Indicator (GEDI) is a ratiometric, dual-fluorescence biosensor that enables real-time detection of cell death through calcium influx. Originally developed for use in neur...