PLoS ONE
Articles in this Issue
Functional effects of extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture: In vitro liver cytotoxicity and proteomic expression alterations
Per- and polyfluoroalkyl substances (PFAS) have become a focal point in public health research due to their widespread use and persistence, leading to global environmental and human exposure. Accumula...
Facilitators of and barriers to labor market participation among people with acquired deafblindness: A scoping review
This scoping review aims to identify factors that facilitate or hinder labor market participation of people with an acquired hearing and vision impairment, also...
Retraction: The regulation of HBP1, SIRT1, and SREBP-1c genes and the related microRNAs in non-alcoholic fatty liver rats: The association with the folic acid anti-steatosis
Initial arterial access used and associated factors in coronary procedures: A retrospective study from a tertiary indian center
Background Transradial access (TRA) is increasingly preferred over transfemoral access (TFA) for coronary procedures due to its safety profile. However, uptake varies across clinic...
Prevalence of generative artificial intelligence sexualized image usage by adolescents in the United States
The prevalence of generative artificial intelligence (GenAI) usage related to sexualized images amongst adolescents is a critical emerging research area. In this exploratory study, a nationally repres...
BioFuse: an embedding fusion framework for biomedical foundation models
The biomedical field has witnessed a surge in pre-trained foundation models excelling in specific subdomains such as radiology and histopathology. While integrating these models promises a more compre...
Polydrug use with opioid involvement: Results from a national sample of U.S. civilians aged 12 years or older
This study examined the prevalence and patterns of polydrug use among a national sample of civilians aged 12 years or older, with a focus on polydrug use involving opioids, assessing the influence of...
Integrated network pharmacology and comprehensive bioinformatics analysis to identify the mechanisms and molecular targets of ketamine in ischemic stroke–depression comorbidity
Comorbid depression following ischemic stroke is a debilitating condition with complex pathophysiology. Although ketamine demonstrates rapid antidepressant effects, its molecular mechanisms in the con...
Excessive manganese content in children’s multivitamin supplements: Potential for neurodevelopmental harm and other adverse health outcomes
Background Manganese (Mn) is an essential nutrient vital for many physiological processes, but it can cause adverse health effects at high exposures, particularly during neurodevel...
Application of seasonal-adjusted hybrid models for forecasting Discomfort Index in a heat-prone region of Bangladesh
Extreme heat and humidity pose an increasing threat to human health, labor productivity, and overall well-being, particularly in heat-vulnerable and rapidly urbanizing regions such as Rajshahi, Bangla...
Correlation between clinical disease activity and interferon-γ autoantibody titers measured by inhibitory ELISA, and inflammatory biomarkers in adult-onset immunodeficiency associated with anti-interferon-γ autoantibodies
Background Anti-interferon-γ autoantibodies (Anti-IFN-γ AAbs) contribute to immunodeficiency and increase susceptibility to intracellular infections, particularly in adults. Measur...
Mode of action-specific and cause-specific retention of biologic and targeted synthetic disease-modifying antirheumatic drugs in anti-SS-A antibody-positive rheumatoid arthritis: The ANSWER cohort study
Anti-SS-A (Ro) antibody-positive rheumatoid arthritis (RA) constitutes a clinically important subgroup, but its impact on retention of biologic or targeted synthetic disease-modifying antirheumatic dr...
Association between vaginal washing and group B Streptococcus colonization from periconception through the first trimester of pregnancy in a cohort of Kenyan women
Introduction Vaginal washing has been associated with adverse reproductive health outcomes including pelvic inflammatory disease, reduced fecundability, and HIV acquisition. This a...
Fisheries ecological knowledge, FEK: Contribution to the knowledge of the ecology and distribution of houndsharks and dogfish shark (family Triakidae and Squalidae) in the Canary Islands
Currently, it is assumed that most of elasmobranchs (sharks, rays and skates) had suffered a high depletion in their populations worldwide, but there is an important lack of biological and fishing inf...
Accessible and cost-effective methods for patterning cell monolayers on compliant substrates
Micropatterning is a versatile technique for confining single cells and cell monolayers to a particular size or shape. The resulting geometrical confinement is one means of controlling migration, diff...
Designing a flipped AI-chatbot learning module to support students’ environmental literacy development: A Fuzzy Delphi Method
China’s rapid economic growth has exacerbated environmental degradation, posing severe risks to public health and sustainable development. However, current environmental education in higher education...
The impact of delayed reporting on forensic evidence recovery in anal sexual assault cases: A retrospective study
Background Delayed presentation after sexual assault reduces the probability of detecting injuries or recovering biological evidence. Evidence specific to anal-route allegations an...
Single-tube two-step RPA-CRISPR/Cas12b platform for detection of Pseudomonas aeruginosa
Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen of significant clinical and public health concern, necessitating the development of rapid and reliable detection metho...
Food and feed safety of a novel Vip3C insecticidal protein derived from Paenibacillus spp. for protection of crop plants against key Lepidopteran pests
Bacillus thuringiensis insecticidal proteins have been safely and effectively used for several decades as tools for insect pest control either as active ingredients in biopesticide...
Material stock and environmental burdens of coastal bridge infrastructure in China: A bottom-up life cycle perspective
China’s rapid expansion of maritime infrastructure has positioned coastal bridges as critical components of national economic and transport strategies. However, their material stock scale, material in...
Comparison of thyroid hormones reference intervals based on thyroid antibody levels: A multicenter study
Objectives This study aimed to determine reference intervals (RI) for thyroid hormones based on thyroid antibody levels using different autoanalyzer kits....
ESG disclosure quality and firm valuation under economic policy uncertainty: Evidence from Chinese A-share listed firms
This study examines the extent to which high-quality environmental, social, and governance (ESG) disclosure mitigates the effects of economic policy uncertainty (EPU) on enterprises’ market valuation....
Sustainable chitosan and medicinal plant oils as natural edible coatings for postharvest quality preservation of guava fruits (Psidium guajava L.)
Postharvest loss of tropical fruits remains a significant challenge for food security and sustainability, as their delicate texture and high metabolic activity make them highly susceptible to rapid de...
Exogenous estradiol does not regulate daily metabolic rhythms underlying diet-induced obesity in male mice
Male mice fed high-fat diet become obese, but female mice are resistant to diet-induced weight gain. We previously found that circulating estradiol in females protects their daily rhythms from disrupt...
Silence in physician clinical practice: a scoping review protocol
Objective The objective of this review is to map, describe and conceptualize how silence is discussed within literature on interactions between physicians and patients, in clinical...