PLoS ONE
Articles in this Issue
Preoperative binaural beats reduce remimazolam dosage and enhance safety in anesthesia induction: A randomized controlled trial
Binaural beats, a form of auditory stimulation, are thought to reduce anxiety and anesthetic requirements through brainwave entrainment. Remimazolam offers advantages in terms of rapid onset and offse...
Analytical framework for evaluating NMPC-based robot navigation in fluid environments
This paper presents a novel hybrid simulation framework by combining nonlinear model predictive control (NMPC) and the lattice Boltzmann method (LBM) for autonomous robot navigation in dynamic environ...
Untargeted metabolomics for the early detection of preeclampsia: A systematic review of human studies
This systematic review synthesizes current evidence on metabolomics-based biomarkers for the early prediction or diagnosis of preeclampsia and highlights promising candidates with potential clinical a...
Joint modelling of left- and interval-censored viral load for couples in Mozambique
Mathematical and statistical models have been essential tools in exploring the dynamics of viral load measures, understanding of the pathogenesis of HIV-1 infection and in assessment of the potency of...
Assessment of miRNAs as transcriptional regulators in respiratory syncytial virus infection through computational analysis and molecular docking studies
Globally, RSV is a major contributor to severe lower respiratory tract infections among children. Despite the significant medical concern posed by RSV, efforts to develop effective vaccines and antivi...
Adaptive traffic signal control using deep reinforcement learning: Toward smarter and safer urban mobility
In today’s rapidly evolving Intelligent Transportation Systems (ITS), traditional systems for controlling traffic signals are often inadequate in optimizing real-time traffic flow due to their depende...
When the source is a bot: How people adapt their evaluation strategies to assess AI-generated content
Generative artificial intelligence (GenAI) blurs the boundaries between expert and non-expert sources, as it increasingly distributes and creates scientific content. This study examines how individual...
Support-seeking and rehoming pathways differ by surrender circumstances among pet owners
Animal shelters aim to divert intake by encouraging pet retention in homes (e.g., support services) or through alternative methods of surrender (e.g., self-rehoming); however, it remains unclear what...
Temporal-spatial trends in childbirth in Ontario, Canada
Introduction The importance of understanding the continuum of care throughout the perinatal/postpartum periods is important for health system monitoring and quality improvement. In...
Price elasticity of demand for cigarettes in Nepal: Evidence from a lower middle-income country in South Asia using Deaton’s demand model
Background In South Asia, taxation policies are popular instruments to reduce high cigarette demand which work through directly affecting cigarette prices. The effectiveness of suc...
Unraveling the toxicological impact of Bisphenol A exposure on dermatomyositis: An integration of network toxicology and machine learning approaches
Background Dermatomyositis is a common immune-mediated skin disorder whose pathogenesis has not been fully elucidated. Environmental factors play a key role in its onset and progre...
Exploring the spatial coupling relationship between green vegetation carbon stock and recreational intensity in urban parks: A case study of Hangzhou
As an important form of green space within densely built urban environments, optimizing the layout of city parks based on the synergistic integration of carbon stock and recreational services level ho...
Assessing Local Differential Privacy for Compliance with the Personal Data Protection Law in Integrated Data Systems
Organizations increasingly integrate and share person-level data across internal platforms and external partners to enable analytics, digital services, and evidence-based decision making. However, com...
Filling the gaps between tide gauges: Demonstrating high-resolution seasonal high tide flooding predictions using NOAA’s Coastal Ocean Reanalysis
High Tide Flooding (HTF) is a present and increasing hazard for coastal communities across the United States. NOAA provides HTF outlooks at U.S. tide gauges, however, many coastal communities lie rela...
Evaluation of a training program for rheumatic heart disease screening integrated into the public health system in Uganda
Introduction Echocardiography screening for rheumatic heart disease (RHD) has gained support as a public health approach, but scale up of RHD screening services is complex. We soug...
Proteome-based investigation of O-GlcNAcylation in a C. elegans model of ageing and Alzheimer’s disease: Functional support for earlier hypothesis-generating findings
O-linked N-acetylglucosamine (O-GlcNAc) is a post-translational modification of serine and threonine residues on nuclear and cytoplasmic proteins. The identity of O-GlcNAcylated proteins during ageing...
Dual-channel feature fusion network for sheep diseases question classification
To address the challenges of feature sparsity, semantic ambiguity, and insufficient feature extraction in sheep disease question classification, this paper proposes a novel model named Dual-Channel Fe...
Vibration-based bearing fault diagnosis in noisy conditions using matrix pencil mean frequency and multilayer perceptron neural networks
Bearings are critical elements in rotating machinery, where failures often accelerated by noise interference can cause severe economic and safety consequences. Reliable fault detection in noisy enviro...
Multidimensional factors influencing continuance usage intention of university library self-service systems: An empirical analysis based on an extended TAM-UTAUT
With the advancement of smart library initiatives in higher education institutions, the automation of circulation services has emerged as a critical component. Automated literature services alleviate...
Correction: Factorial and Network Structure of the Reynolds Adolescent Depression Scale (RADS-2) in Peruvian Adolescents
Resistance gene profiling of beta-lactamase and carbapenemase in gram-negative blood isolates: A tertiary care hospital
The global rise in antimicrobial resistance is largely driven by DNA-encoded, antibiotic-hydrolyzing enzymes. This study aimed to determine the prevalence of ESBL, AmpC-BL, MBL, and carbapenemase gene...
The rationalization of carbon monoxide and hemoglobin association
Background/objective Carbon monoxide (CO) is a colorless, odorless toxic gas responsible for approximately 100,000 emergency department visits and more than 420 deaths annually in...
Exploring prenatal care experiences in Ontario, Canada: An equity-oriented qualitative study
Introduction The extent to which prenatal care is equity-oriented significantly influences patient satisfaction, care-seeking decisions, and health outcomes for both parent and new...
Implementation tendencies and expert perspectives on physician-performed prehospital endotracheal intubation in Japan: Findings from the first round of a Delphi survey
Standardization of prehospital endotracheal intubation (ETI) has been shown to be essential for improving first-pass success rates and minimizing complications. In Japan, however, physician-performed...
Osteoarthritis in older adults: A global health challenge and the role of high BMI in shaping disease trends
Background This study aimed to estimate the global, regional, and national Osteoarthritis (OA) burden and trends in older adults from 1990 to 2021, with a particular focus on the c...