PLoS ONE
Articles in this Issue
The METTL3 inhibitor STM2457 suppresses gastric cancer progression by modulating m6A RNA modification
Gastric cancer (GC) is one of the most common and lethal cancers globally. methyltransferase-like 3 (METTL3)-mediated N6-methyladenosine (m 6 A) RNA methylation...
Correction: Healthy Minds Index: A brief measure of the core dimensions of well-being
Causes of morbidity and mortality in free-ranging Eurasian lynx (Lynx lynx) in Switzerland, 2000–2022
Health monitoring based on post-mortem examination is essential for the management of endangered animal species. This is especially true for reintroduced species living in small populations with low g...
Factors associated with insomnia, anxiety, and depression among antenatal women in China: A cross-sectional hospital-based study
Background Mental health challenges, including insomnia, anxiety, and depression, are common among antenatal women and can affect both maternal and fetal outcomes. This study explo...
Subject-specific modeling of response to physical stress via hypothalamic-pituitary-adrenal and sympathoadrenal axes
The two main pathways for hormonal stress response are the hypothalamic-pituitary- adrenal (HPA) axis and the sympathoadrenal (SA) axis. The HPA axis produces and secretes cortisol, while the SA axis...
Outcomes of acute meningitis according to immunosuppression status: 15-year retrospective cohort
Acute meningitis remains a primary global health concern. Immunosuppressed patients have risks due to atypical clinical presentations and a broader range of causative pathogens. We aimed to describe t...
Correction: Child training in the Child ViReal Support Program: Combining iVR-based cognitive training and CBT techniques in a pilot study
Correction: Progression of carotid intima-media thickness, visceral fat accumulation and metabolic derangement in people living with HIV initiating antiretroviral therapy: A prospective cohort study at Thailand’s tertiary care center
Risk assessment for cardiovascular adverse drug events in the ICU: Case study on COVID-19 patients
The COVID-19 outbreak quickly became a pandemic. In Brazil, more than seven million cases were recorded in 2020. Most patients affected by the disease were admitted to intensive care units (ICU), requ...
Design considerations for technology-assisted fall-resisting skills training trials in older adults: A pilot and feasibility study
Training fall-resisting skills can prevent falls in older adults. These fall-resisting skills include proactive gait adaptability, gait robustness, and reactive gait recovery, which allow people to ef...
Healthcare access and barriers in Jordan: Insights from a Nationwide Survey
Background Healthcare access disparities are a significant public health concern, particularly in low- and middle-income countries like Jordan. Despite advancements in healthcare i...
Identification of polyphenols as novel neuropilin-1 cendR pocket inhibitors to block SARS-CoV-2 entry and enhance variant resistance
Neuropilin-1 (NRP-1) functions as an essential co-receptor for SARS-CoV-2, facilitating viral entry by binding the spike protein’s C-end rule (CendR) motif in its b1 domain, yet it has received less a...
Determinants of domestic violence against women in Cambodia: How digital access, media exposure, motorcycle ownership, and partners’ alcohol use matter
Domestic violence against women remains a public health and socio-economic burden in Cambodia, with only slow declines over the past two decades. This study examined how digital access, media exposure...
Aurally impressed, yet not more stressed: On the relationship between audiovisual realism, social anxiety, and presence in a virtual social stress scenario
Binaural auralizations can create spatial hearing impressions that closely resemble real sound sources, enhancing immersion and realism in virtual environments. Although social interactions often invo...
Assessment of references for the quantitative analysis of LINE-1 and Alu methylation in cellular DNA and circulating cell-free DNA of cancer patients
The LINE-1 and Alu retrotransposon elements, with more than 90% of their sequences being methylated, contribute to 30% o...
Assessment of a baloxavir marboxil treatment protocol for high pathogenicity avian influenza in Okinawa Rails, an endangered species endemic to Japan
High pathogenicity avian influenza (HPAI) is a highly infectious and lethal disease of birds that causes systemic symptoms and has been spreading globally, including in Japan. The Okinawa rail (...
Time lag between functional and structural lymphatic changes after lymphadenectomy: Insights from ICG lymphography and lymphatic ultrasound
Postoperative lower limb lymphedema is a common complication following pelvic or para-aortic lymphadenectomy for gynecologic cancers. Early detection of lymphatic dysfunction is crucial, but the tempo...
Effects of GABAAR modulators CL218872 and MRK-016 on neural repair and synaptic plasticity in mice with Intracerebral hemorrhage
Background Intracerebral hemorrhage (ICH) is a devastating condition characterized by rapid onset, high rates of disability and mortality, and prolonged recovery. Dysregulated γ-am...
Recombinant Potyvirus lilimaculae in asymptomatic Galanthus nivalis: Ecological and evolutionary implications
Snowdrops are economically important early-spring flowering geophytes. They are protected both in Hungary and across the European Union, and their international trade is regulated under the Washington...
Assessing ecosystem service trade-offs and synergies in the rapidly urbanizing coastal region of Mangaluru Agglomeration, India
The steady growth of the cities alters the urban environmental pattern and functions, posing signs of danger mainly on the ecosystem services. Mangaluru is a coastal city, where rapid urbanization is...
Time to initiate trophic feeding and predictors among preterm neonates admitted at General Hospitals in Tigray, 2025
Back ground Trophic feeding generally refers to providing small quantities of enteral feeding soon after birth. A study in Ethiopia highlighted substantial delays in starting thera...
Redefining multi-target weather forecasting with a novel deep learning model: Hierarchical temporal convolutional long short-term memory with attention (HTC-LSTM-Attn) in Bangladesh
Bangladesh, being a country that relies on agriculture, has its agricultural sector contributing around 20% to the Gross Domestic Product (GDP) and providing employment opportunities for nearly 60% of...
Coenrollment of critically ill patients in PROSPECT: A protocol and statistical analysis plan
Introduction The enrollment of a patient into more than one study (i.e., coenrollment) has risks which warrant exploration, particularly with respect to possible effects on trial o...
Ex vivo and in silico evaluations of (E)-5-((benzo[d]thiazol-2-ylimino)(methylthio)methylamino)-2-hydroxybenzoic acid as a β3-adrenoreceptor agonist exerting anti-obesity, anti-inflammatory and hepatoprotective effects on Zucker rats
Obesity increases oxidative stress and inflammation and thereby promotes liver damage and metabolic disorders, such as type 2 diabetes. Although exist anti-obesity treatments with employing anorexic d...
Correlation analysis and prediction models for loess compressibility in Ili region, Xinjiang
Loess compressibility is a crucial engineering parameter governing the deformation of loess foundations and the evolution of slope geohazards. Based on a comprehensive collection of physical, hydrauli...