PLoS ONE
Articles in this Issue
Evaluating large language models for ADHD education: A comparative study of ChatGPT 5, DeepSeek V3, and Grok 4
Background Children with attention-deficit/hyperactivity disorder (ADHD) often face barriers to participating in organized sports, particularly when physical education (PE) is deli...
Choice and impact of EQ-5D-5L value set in cost-utility analyses alongside multinational trials: Insights from PREFERABLE-EFFECT and CONVINCE
Objectives Multinational clinical trials are increasingly common in the European Economic Area, yet no guideline exists on which EQ-5D value set(s) should be used for health econom...
Introducing the Dutch Quality Registry for Acute Internal Medicine (DRAIM): Method of development and opportunities of use from a single-centre pilot study
Background The Dutch Quality Registry for Acute Internal Medicine (DRAIM) aims to evaluate and improve the quality of care for internal medicine patients presenting in the Dutch ac...
Correction: Unpacking the dual psychological paths of employee-AI collaboration on creativity: The role of proactive behavior
Expression of Concern: Mapping Quantitative Trait Loci of Resistance to Tomato Spotted Wilt Virus and Leaf Spots in a Recombinant Inbred Line Population of Peanut (Arachis hypogaea L.) from SunOleic 97R and NC94022
Facility staff perspectives on the implementation of Maternal and Perinatal Death Surveillance and Response in six health facilities in Kigoma, Tanzania
Background Maternal and Perinatal Death Surveillance and Response (MPDSR) is an important accountability mechanism for preventing avoidable deaths and addressing gaps in care. Heal...
Path analysis of factors associated with nurses’ pain management practices in older adults with cognitive impairment: A cross-sectional study
Background Pain management is essential, yet inadequate management is linked to anxiety, depression, and poor quality of life. Evidence in Thailand is limited for older adults with...
A comparative analysis of the performance of leading large language models on the endodontics section of the dentistry specialization exam in Türkiye
Objective This study aimed to evaluate and compare the performance of eight contemporary LLMs on the endodontics section of the DUS, assessing their accuracy in both theoretical kn...
Combinatorial drug repurposing of Valproic acid and Zebularine regulates Krüppel-like factor 4 and β-catenin expression in colon cancer cells
Colorectal cancer is the predominant and recurring cancer leading to the second largest cause of mortality, globally. Abnormal regulation of oncogenes and deactivation of tumor suppressor genes over a...
Ring-augmented versus conventional one-anastomosis gastric bypass: Perioperative and short-term results in the randomized controlled RiMini trial
Purpose Recurrent weight gain remains a challenge in metabolic bariatric surgery (MBS). Recent publications focused on ring-augmented Roux-en-Y gastric bypass (RYGB) and ring-augme...
Prevalence of Congenital Heart Disease and Associated Factors among Infants with Myelomeningocele: A cross-sectional study
Background Meningomyelocele (MMC) is believed to commonly coexist with congenital heart disease (CHD), due to embryological pathways involving neural crest cells and risk factors s...
Residual-guided hybrid framework for adversarially robust deep learning-based network intrusion detection
The growing sophistication of cyber threats and adversarial attacks poses critical challenges to the security and robustness of machine learning models deployed in real-world systems. While traditiona...
Longer durations of piperacillin/tazobactam treatment cause more prolonged alteration of colonization resistance in mice
Broad-spectrum antibiotics that are excreted into the intestinal tract disrupt microbiota that provide colonization resistance against healthcare-associated pathogens. Minimizing the duration of treat...
Knowledge about Alzheimer’s disease in medical, nursing, and psychology students in Ecuador: A problem that needs an urgent solution
Background Alzheimer’s disease represents one of the greatest healthcare challenges of the 21st century due to the aging population and its impact on the quality of life of patient...
GEC-DTSP: A GNN–RL-based Edge–Cloud Digital Twin framework for real-time traffic forecasting and adaptive signal control
Urban traffic networks exhibit highly dynamic and nonlinear spatiotemporal interactions that require predictive modeling and adaptive control mechanisms capable of operating under low-latency constrai...
Human versus AI in audiological practice: A comparative evaluation of ChatGPT and physician treatment decisions in idiopathic sudden sensorineural hearing loss
Purpose Artificial Intelligence (AI) is increasingly being applied in the field of audiology, demonstrating potential to support screening, diagnosis, and rehabilitation in auditor...
Risk factors for mortality in prostatic abscess: Insights into patient characteristics and drainage practices
Prostatic abscess, which is an uncommon urinary tract disease, can lead to mortality if not properly treated. This retrospective study aimed to identify risk factors associated with mortality in patie...
Determinants of digital health literacy among health professionals: Evidence from public and private hospitals in Eastern Ethiopia
Background Digital health literacy has become essential for effective clinical practice as healthcare systems increasingly adopt digital technologies. However, many low- and middle...
Expression of Concern: InDel markers: An extended marker resource for molecular breeding in chickpea
Valuing conservation and natural wealth: The blue economy of manta ray watching in the Maldives
Amid declining manta ray populations globally, the well-established and growing manta ray tourism industries generate substantial economic benefits and aid protective legislation for these threatened...
Magnesium neuroprotection in retinal ganglion cells: A computational study of frequency-dependent therapeutic windows and intervention timing
Retinal ganglion cells (RGCs) are vulnerable to excitotoxic damage mediated by excessive NMDA receptor activation and calcium overload. Extracellular magnesium (Mg 2+...
Bisphenol BPAF and BPC are agonists for estrogen receptor ERα but antagonists for N-terminal domain-lacking ERα
In the DNA complex of coactivator-bound estrogen receptor alpha (ERα), the N-terminal domain (NTD) and C-terminal ligand-binding domain (LBD) interact specifically. ERα-NTD and LBD constitute activati...
Evolving graph attention networks for dynamic link prediction
Graph neural networks (GNNs), which learn node representations via aggregating their neighbors, have shown superior performance and become the de facto efficient toolkit for analyzing and learning fro...
Expression of Concern: Identification of stable heat tolerance QTLs using inter-specific recombinant inbred line population derived from GPF 2 and ILWC 292
Markers of kidney tubule dysfunction and injury and long-term risk of acute kidney injury following coronary artery bypass graft surgery
Background Approximately one in five patients undergoing coronary artery bypass graft (CABG) surgery will develop post-operative acute kidney injury (AKI). We sought to determine w...