PLoS ONE
Articles in this Issue
Identification of AC025811.3 and AC012354.6 as two critical survival-related lncRNAs for uterine corpus cancer
Uterine corpus endometrial carcinoma (UCEC) ranks as the most frequently diagnosed gynecologic malignancy and the second leading cause of gynecologic cancer-related mortality. Long non-coding RNAs (ln...
Motherhood choice in multiple sclerosis (MoMS) – Pilot trial of web-based decision support
Backgroud Uncertainty concerning motherhood is common among women with multiple sclerosis (wwMS). Therefore, we developed and pre-tested a patient decision aid (PtDA) and a nurse-l...
Delays in diagnosis and treatment of depressive disorder among young adults: A national online survey-based cross-sectional study
Background Depression is highly prevalent among U.S. young adults and associated with long-term functional impairment and increased suicide risk. While delays in diagnosis and trea...
Correction: Predicting poor functional outcomes for patients with large computed tomography perfusion core infarctions treated with endovascular thrombectomy
A reliability assessment of the basic erosive wear examination and the tooth wear evaluation system 2.0 utilizing intraoral scan data
Objectives This study assessed the reliability and clinical applicability of two tooth wear screening indices—Basic Erosive Wear Examination (BEWE) and the Tooth Wear Screening mod...
Cost-effectiveness analysis of mammography screening for early detection of breast cancer in Nigeria
Mammography still remains the gold standard for breast cancer screening, considering its impact on breast cancer mortality. However, it has a relatively low utilization rate in Nigeria. Although the N...
Gender differences in the relationship between adult attachment and self-identity: A network analysis research among Chinese college students
Objective This study aims to investigate the relationship between adult attachment and self-identity among Chinese college students using network analysis, with a specific focus on...
Research on fine-tuning algorithms for Large Language Models integrating Uncertainty Modeling and External Memory Augmentation
This paper proposes a parameter-efficient fine-tuning framework that integrates uncertainty modeling with external memory augmentation, aiming to improve robustness, confidence calibration, and contex...
Quercetin suppresses the progression of HBV-associated hepatocellular carcinoma by modulating the EGFR signaling pathway
Background Quercetin, a bioactive flavonoid compound widely present in medicinal and edible plants, has demonstrated therapeutic potential against hepatocellular carcinoma (HCC). H...
Comparing the uplink performance of 3D and 2D antenna models in THz networks in the presence of joint human and wall blockages
Terahertz (THz) communication is considered as a key technology enabler for realizing Sixth Generation (6G) network. THz band communication offers several promising advantages, but numerous challenges...
Representing national images of self and others through China’s diplomatic discourse: A corpus-based study
Drawing on van Dijk’s Ideological Square framework, this paper adopts a corpus-based method to examine the discursive strategies in their responses by the spokespersons for China’s Ministry of Foreign...
Joint optimization of task offloading and energy trading in edge-enabled smart grids using deep reinforcement learning
The proliferation of distributed energy resources (DERs) and the ubiquity of Internet of Things (IoT) devices are driving the integration of mobile edge computing (MEC) into smart grids. This converge...
Correction: A new criterion for defining tunnel portal failure using the strength reduction method
Development and validation of search hedges for Transgender and Gender Diverse (TGD) populations in Ovid MEDLINE and Ovid APA PsycInfo
Introduction This paper describes the development and validation of highly sensitive search hedges for Ovid MEDLINE and Ovid APA PsycInfo that effectively identify literature on tr...
Real-time detection of rare roadside obstacles using YOLOv8-n in autonomous vehicles
Rare road obstacles, including traffic cones, fallen trees, debris, barrels, and rocks, pose significant safety risks to autonomous vehicles. This paper presents a lightweight real-time detection fram...
Unimodal vs. multimodal deep learning for non-invasive MGMT promoter methylation prediction in glioblastoma: A systematic evaluation on the BraTS 2021 dataset
Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults, with a median survival of 14.6 months under standard radiotherapy and temozolomide (TMZ) chemotherapy. The methylati...
Long-term trends in height, weight and body mass index of children and adolescents in Macao Special Administrative Region (China), 2005–2020
Objective To assess long-term trends in height, weight and body mass index (BMI) among children and adolescents from 2005 to 2020 in Macao Special Administrative Region (SAR), Chin...
Time-to-event ensemble machine learning approach for predicting long-term survival of abdominal aortic aneurysm patients undergoing endovascular aneurysm repair
Background Endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA) is associated with risks such as endoleaks and late aneurysm rupture, highlighting the importance...
Who becomes a dermatologist? A repeated cross-sectional study on diversity in the Dutch dermatology workforce
Background Workforce diversity in dermatology is crucial for equitable, high-quality care, given the impact of skin tone, culture, and socio-economic status on skin conditions. Alt...
The Good Life with Dementia approach: A realist-informed qualitative study of a peer-tutored course, co-produced with and for people living with dementia
People with dementia often report a lack of post-diagnostic support, and much of the current dementia training available is for staff or carers, not for the person diagnosed. The Good Life with Dement...
Role of Najran University Scholarship Students in the United Kingdom in cultural bridging and civilizational dialog
This study explores the role of Najran University scholarship students in the United Kingdom in promoting cultural bridging and civilizational dialog. To achieve this objective, a structured questionn...
Effects of tibialis anterior contraction on the medial longitudinal arch and hallux valgus angle: A functional anatomical perspective
This study aimed to elucidate the effects of the tibialis anterior (TA) muscle contraction on the medial longitudinal arch (MLA) and hallux valgus (HV) angle, primarily focusing on the potential funct...
Antioxidant, antibacterial, in vitro, and in silico α-glucosidase inhibition activities and chemical profiling of Usnea cornuta Korb
The total phenolic content and flavonoid content of the Usnea cornuta extract were evaluated as 210.31 ± 2.87 mg GAE/g and 22.42 ± 0.78 mg QE/g, respectively. T...
Conceptual thermal constraints on the growth of the first tree on a terraformed Mars
The environmental conditions on present‑day Mars are far outside the range tolerated by known complex terrestrial life. Conceptual climate studies have suggested that, in hypothetical terraforming sce...
The mTOR/Akt pathway is involved in regulating astrocyte growth and GLT-1 expression during cerebral ischemia-reperfusion
Stroke is one of the most prevalent causes of death and disability worldwide and places a heavy economic burden on families and society. High glutamate accumulation and subsequent excitotoxicity after...