PLoS ONE
Articles in this Issue
Victim framing shapes attitudes across diverse contexts
A person accused of victimizing others may be described as the “real” victim by their defenders to garner empathy and mitigate blame. Recent research shows that this rhetorical strategy, known as “vic...
Implementation bottlenecks of near point of care HIV viral load monitoring for children and young people in Tanzania: A Qualitative Study
Background Near point-of-care (n)POC Human Immunodeficiency Virus (HIV) viral load (VL) monitoring, consisting of VL testing in laboratories close to HIV treatment facilities, impr...
Mandatory lane-changing decision and control method based on game theory
This paper proposes a lane-changing decision and control framework for mandatory lane-changing scenarios based on stage game decision-making. The lane-changing process is discretized, and payoff funct...
HybFusion: A holistic Android malware detection framework with advanced feature fusion and ensemble learning
Android malware detection remains a critical challenge due to the rapid increase in malware variants and the growing sophistication of obfuscation techniques. To address these issues, this paper intro...
Is asymmetric upper trapezius muscle activation during work associated with neck pain? A cross-sectional and longitudinal analysis
Objectives Previous studies have linked activity in the upper trapezius muscle with neck pain. However, no studies have examined whether asymmetric activation of these muscles duri...
Study on the adaptability of multilayer subway network under sudden large passenger flow disturbances
This paper proposes a multilayer network-based subway network adaptability assessment framework.Adaptability is defined as the ratio of post-disturbance cumulative network performance to its nominal v...
Developing an evidence-based framework of contemporary character development at Outward Bound Schools
This paper presents an evidence‑based framework for character development across the global network of Outward Bound (OB) Schools. Using the Eisenhardt multiple‑case, cross‑case theory‑building method...
Evaluating respiratory syncytial virus immunization strategies for infants in Canada: A cost-utility analysis
Background Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections and hospitalizations among infants in Canada. New long-acting monoclonal antib...
Citizen satisfaction with public services in Peru: Regional gaps in citizen perceptions of public service provision
Citizen satisfaction with public services is a fundamental indicator of government effectiveness and democratic legitimacy in Latin America. However, there is little empirical evidence on regional gap...
Discharge health education needs and experiences of patients with skeletal-related events from bone metastases: A qualitative study
Objective To describe the health education needs and experiences of patients with skeletal-related events due to bone metastasis from solid tumours upon discharge and to provide a...
Three-dimensional dynamic response of infinite plate resting on multilayered orthotropic foundation under moving loads
In response to the dynamic response of layered foundation pavement structures caused by traffic loads, a three-dimensional coupled model of an infinite elastic plate on an orthotropic layered foundati...
An optimization method for flexible interconnection planning based on improved CNN-LSTM prediction and tunable relative entropy-driven chaotic evolution
As power systems evolve towards greater intelligence and flexibility, flexible interconnection technology has emerged as a critical means to enhance operational reliability and economic performance. T...
Comparative analysis of isokinetic ratios between hamstrings and quadriceps in wrestlers: Resting state versus post-fatigue evaluation
Introduction Wrestling demands high-intensity competition, and tournament structures often require athletes to compete in multiple matches in a single day. T...
Beggar thy neighbour or befriend thy neighbour? Asymmetric spillovers of China’s double world-class policy
Higher education policies commonly engender certain spillover effects, which frequently remain unaccounted for within the formal policy evaluation framework. Focusing on China’s Double World-Class (DW...
Cross-dataset benchmarking of machine learning models for marine and atmospheric environmental prediction
Accurate prediction of marine and atmospheric environmental variables is important for climate adaptation, ecosystem management, and operational decision-making, yet practitioners still lack clear gui...
Molecular characterization of superficial zone chondrocytes under pro-inflammatory and biomechanical stress conditions
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pathological features such as chondrocyte loss and cartilage matrix degradation. Superficial zone chondrocytes (SFC), locat...
Cardiologists’ perspectives on pharmacogenomics implementation in a hybrid health system: A qualitative study from the United Arab Emirates
Background Pharmacogenomics (PGx) can optimise cardiovascular therapy, yet routine integration in cardiology remains limited. In the United Arab Emirates, a hybrid public–private h...
Remote medical system driven by medical big models: Dynamic defense model for network security threats
As telemedicine systems become increasingly interconnected and medical big models are more widely deployed, remote medical infrastructures face growing cybersecurity risks. Traditional static defense...
Identification of candidate sex hormone-associated genes and immune infiltration characteristics in osteoarthritis based on bioinformatics analysis and machine learning
Background Sex hormones play critical roles in the pathogenesis and progression of osteoarthritis (OA), yet the hormone-related molecular networks remain poorly defined. This study...
Importance of developmental stage and microenvironment control in Zebrafish larvae cardiovascular studies
Zebrafish ( Danio rerio ) are widely used as models in cardiovascular research due to their rapid development, optical transparency, and genetic similarity to h...
Perspectives of community-dwelling older adults with chronic diseases on Baduanjin practice: A qualitative study
Background With the accelerating aging of China’s population, Baduanjin has been promoted as a community-based exercise to enhance public health, particularly among older adults wi...
Pathways of health care for people living with multimorbidity in two Southern African countries
Multimorbidity, the presence of multiple chronic conditions in one person, is a growing global health concern. Integration of chronic care services is urgently needed, especially in low-resource setti...
Environmental footprint quantification and optimization methods for digital poster design based on life cycle assessment
Digital poster design has become a dominant visual communication medium, yet its environmental impacts remain poorly understood despite assumptions of inherent sustainability. This research developed...
Limited efficacy of a therapeutic anti-CD40 monoclonal antibody to inhibit activated CD4 T cell autoimmunity in vitro
Iscalimab is a nondepleting anti-CD40 monoclonal antibody, expected to suppress immune responses by blocking the costimulation by antigen-presenting cells through CD40-CD40L ligation. This therapeutic...
Empowering rural governance with digital technology: Deep learning models for automated detection of rural buildings using remote sensing images
Building detection from drone imagery represents a transformative approach to rural governance by enabling precise spatial data acquisition for critical applications including illegal construction mon...