PLoS ONE
Articles in this Issue
Modeling diffuse midline glioma through triple-electrode in utero electroporation of the developing mouse pons
The leading cause of brain cancer–related death in children is diffuse midline glioma (DMG). A particularly aggressive DMG subtype is pontine DMG (formerly diffuse intrinsic pontine glioma, DIPG), whi...
Phage mediated growth inhibition and biofilm disruption of the endodontic pathogen Enterococcus faecalis
The failure of endodontic procedures such as root canal therapy is primarily indicated by persistent microbial infections. Root canal therapy involves the removal of decaying dental pulp (internal blo...
Construction and validation of an instrument to assess the university dropout intention formation process UDIFP-29
A significant body of research supports the importance of addressing university students’ dropout intention, the process through which university students form the intention to dropout from their stud...
A semantic segmentation model to predict subcellular glycogen localization using transmission electron microscopy images
Transmission electron microscopy (TEM) is the gold standard for assessing subcellular glycogen localization in skeletal muscle fibres, but conventional manual analysis is extremely time-consuming and...
REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effect
Background Ageing is associated with reduced resilience to physiological stressors such as infection and surgery. This reduced resilience is believed to be underpinned by the hallm...
“You never know what’s in front of you”: A mixed methods study of barriers and facilitators to physical activity among blind and low-vision adults with type 2 diabetes
Individuals living with type 2 diabetes and vision loss experience unique, under-researched barriers to physical activity, despite the important role exercise plays in diabetes management. This study...
A hybrid transformer-BiLSTM model optimized with Firefly Algorithm for network traffic anomaly detection
Network Traffic Anomaly Detection (NTAD) is essential for proactive cyber defense against increasingly sophisticated threats. This paper presents a data-driven framework that integrates adaptive signa...
Maternal exposure to oil spill and children’s mental health: The mediating role of resource loss
Objectives To assess the effect of maternal oil spill exposure on children’s mental health and examine whether maternal resource loss mediated this relationship....
Mechanical behavior and constitutive modeling of CO2-foamed carbonated MgO-based solidified slurry under Unconsolidated Undrained (UU) triaxial conditions
Geotechnical construction activities, such as shield tunneling and pile foundation construction, generate large amounts of high-water-content waste slurry, making its disposal and resource utilization...
Siderophore screening in marine sponge extracts using LC-HRMS and an R-based metabolomics workflow
Siderophores are pivotal iron-acquisition biomolecules integral to microbial survival, pathogenicity, and ecology. Elucidating these compounds offers critical insights into the microbial dynamics of...
“The impact of COVID-19 on employee productivity and the future of remote work”
Purpose This paper explores the impact of the COVID-19 pandemic on employee productivity and the future of remote work beyond the pandemic years. Using data collected from 646 remo...
All-optical doubly resonant cavities for energy-efficient ReLU function in nanophotonic deep learning
This paper presents a novel approach to implementing all-optical Rectified Linear Unit (ReLU) activation functions using compact doubly-resonant cavities with dimensions of approximately 10...
Comparative mediation analysis of dog and cat ownership and perceived stress
Companion animals, such as dogs and cats, are widely reported to be associated with lower stress, yet species-specific differences remain unclear. We conducted a comparative mediation analysis to exam...
Modeling the association between psychological capital and nurses’ job performance: The moderating role of intolerance of uncertainty
This cross-sectional analytical study aimed to examine the relationship between psychological capital (PsyCap) and nurses’ job performance, as well as the moderating role of intolerance of uncertainty...
Optimized detection of caspase-6 activation in a murine inflammation model to inform neurodegenerative disease therapies
Caspase-6 (casp-6), is a member of the apoptotic family of caspases (cysteine aspartic proteases) and has been shown to be involved in several neurodegenerative diseases, including Alzheimer’s disease...
Comprehensive insights into the prescribing trends of carbamazepine, lamotrigine, lithium, and valproate in the UK Primary Care from 1995 to 2018
Background Mood stabilisers carbamazepine, lamotrigine and valproate remain the cornerstone medication in the treatment of epilepsy, and in the management of psychiatric disorders...
Scrolling for science: Assessing the quality and accuracy of Crohn’s disease-related content on Instagram reels
Background There is a concerning trend of misinformation of healthcare related content on social media. Recent studies have examined themes and narratives about Crohn’s disease but...
A path planning approach for ship collision avoidance integrating BRB reasoning and velocity obstacle algorithm
Reliable path planning for ship collision avoidance remains challenging in complex maritime environments with dense traffic. This study proposes a novel approach that integrates Belief-Rule-Based (BRB...
Robot-assisted reconstruction using ureteroureterostomy and Lich–Gregoir ureteral reimplantation for complicated duplex kidneys in children
Objective This study aimed to evaluate the efficacy of robot-assisted reconstruction using end-to-side ureteroureterostomy (UU) and Lich‒Gregoir ureterovesical reimplantation (UR)...
Development and usability evaluation of HOPE: A patient-centered mHealth application for HTN self-management in Iran
Background Hypertension (HTN) is a major global health problem and a significant risk factor for cardiovascular disease. Mobile health (mHealth) applications offer an efficient, pa...
Mechanical properties of ECC connection plates in seamless Bridges
Seamless bridges require high-performance connection systems due to the elimination of expansion devices. This study investigates the flexural performance of ECC connection plates (ECP) for seamless R...
Retraction: Analysis of disease burden and future trends of ischemic heart disease in China and globally, 1990–2023
Correction: Air pollution in the places of Betula pendula growth and development changes the physicochemical properties and the main allergen content of its pollen
Preventive spare parts supply strategy for large-scale equipment based on performance degradation
Timely replacement of spare parts can improve the reliability of large-scale equipment operation and is the critical link of preventive maintenance. This paper studies how to reasonably formulate spar...
LXNet: A lightweight CNN for lung disease classification from Chest X-ray with XAI-based interpretability
The diagnosis of lung diseases such as pneumonia and tuberculosis remains a major global health challenge, especially in resource-limited regions. Artificial Intelligence (AI) has shown strong potenti...