PLoS ONE
Articles in this Issue
Addressing the disposal of unused and expired medications in Saudi households: Time to bridge the regulatory gaps
Introduction This study aimed to investigate the awareness, and practice towards disposal of unused, leftover, and expired medications among the residents of Qassim, Saudi Arabia....
From words to action? Linking ESG reports to environmental performance
Companies increasingly use ESG reports to communicate their environmental priorities, yet it remains unclear whether the issues they emphasise correspond to measurable improvements in environmental pe...
Depositional architecture and post-depositional alteration of the Toutunhe Formation (J2t) in the Louzhuangzi area, Southern Junggar Basin: Implications for uranium mineralization
In recent years, economically significant sandstone-hosted uranium mineralization has been identified in the Louzhuangzi area along the southern margin of the Junggar Basin. However, the controls on u...
Spatio-temporal changes in clusters of gastric cancer incidence: The impact of nationwide cancer control programs in South Korea
Background Gastric cancer (GC) is a global health concern, with incidence and mortality varying significantly across populations. The spatial heterogeneity of GC may reflect differ...
Upregulation of RPLP1 in PBMCs as a screening biomarker for melanoma
Early detection of melanoma is essential for improving patient outcomes. This research aimed to identify upregulated gene expression in peripheral blood mononuclear cells (PBMCs) induced by secretory...
Diagnostic performance of discriminant formulas and machine learning models for detecting β-thalassemia trait in Bangladesh
Background β-thalassemia poses a considerable public health burden in Bangladesh, where a high carrier frequency underlies widespread disease risk. It is necessary to distinguish β...
Participatory Rapid Appraisal and Focus Groups to co-design technology-supported integrated care
Background Co-design methods, which create innovation tailored to the end-user needs and setting, are increasingly used to improve research uptake and impact...
Screening disease feature genes and analyzing correlations with immune cell infiltration in knee osteoarthritis chondrocytes based on multiple machine learning algorithms
Objective This study aimed to comprehensively analyze differentially expressed genes (DEGs) in chondrocytes from patients with knee osteoarthritis (OA) by integrating multiple mach...
Association between increased duodenal eosinophil count and functional dyspepsia
Background Functional dyspepsia (FD) is a common gastrointestinal disorder with multifactorial pathogenesis. Recent evidence suggests that duodenal eosinophilia may contribute to l...
Study protocol on antimicrobial resistance burden, transmission dynamics, and therapeutic bacteriophages in livestock and exposed farming populations in Nagpur, India: An integrated One Health approach
The rise in antimicrobial resistance (AMR) is a severe public health threat worldwide. India bears a disproportionately heavy burden of this problem due to ample antimicrobial usage in both humans and...
Mapping the terminology of the early rescue chain to the Foundation of ICD-11: Registered report protocol
Background The World Health Organization (WHO) emphasizes digital technologies as a key accelerator for strengthening health emergency preparedness and response. One such applicati...
Hypergravity reduces F-actin accumulation in osteoclasts, with attenuated bone resorption
Bone loss occurs in astronauts during prolonged spaceflight, thus indicating the sensitivity of skeletal homeostasis to altered gravitational environments. Previous studies have shown that microgravit...
Developing internationally agreed core indicators for surveillance of preconception health: protocol for a consensus study
Background Interventions and policies to optimise preconception health are increasing internationally. This stems from growing recognition that improving preconception health can i...
Frailty in older maintenance hemodialysis patients: A latent class analysis revealing personalized management
Background Elderly patients undergoing maintenance hemodialysis (MHD) exhibit an elevated risk of frailty, which is strongly associated with adverse clinical outcomes, including in...
Echocardiographic characterization and markers of cardiovascular risk in adults with sickle cell disease in a Colombian tertiary referral centre: A cross-sectional study
Sickle cell disease (SCD) is associated with substantial cardiovascular morbidity, but echocardiographic data from Latin American populations remain scarce. We aimed to characterise the structural, fu...
Long COVID risk by pre-infection symptoms and functional status: A retrospective cohort study of data from the All of Us Research Program
Importance Over seven million U.S. adults experience persistent health issues after COVID-19, known as “long COVID”. Although multiple guidelines recommend the inclusion of functio...
Association between menstrual-related disorders and sexually transmitted infections: A nationwide cross-sectional study in Japan
Background To investigate the association between menstrual-related disorders and sexually transmitted infections (STI) among young women in Japan, and to examine differences accor...
Correction: Dialogic Social Impact Analysis of Companies and Organizations (DSIACO): A pioneer model for evaluating social impact of companies and organizations
Prediction of pre- and postfusion conformations of class I fusion proteins with AlphaFold2
Viruses such as coronaviruses or filoviruses use their surface glycoproteins (GPs) to attach to the host cell, triggering the fusion of the viral membrane with the endosome membrane. Epitopes on the v...
Persistent symptoms, cognitive impairment, and clinical predictors of long COVID one year after Omicron infection: A clinical case–control study from the Faroe Islands
Background Six years since the emergence of SARS-CoV-2, the newer variants of the virus continue to have long-term health effects....
A fusion-deletion genomic-event underlies poor prognosis in young patients with luminal breast cancer
Breast cancer in young patients, particularly those with the luminal subtype, exhibits more aggressive behavior and poorer clinical outcomes compared with older patients. However, the genomic mechanis...
PianoGym: Safe post-action piano rhythm training with fatigue constraints
Bimanual piano rhythm training must maintain precise interlimb timing under limited practice time and under fatigue constraints, while feedback on performance is typically available only after an exer...
Combined effect of metabolic syndrome and cancer on depression
Background Cancer survivors frequently experience depression and metabolic dysfunction; however, the combined impact of these conditions remains understudied....
Designing the syllabus for the EAP course “Architectural Art English”: A needs and genre analysis-based approach
This paper details the design and development of a discipline-specific English for Academic Purposes (EAP) syllabus for undergraduate students majoring in architecture and design related disciplines i...
Characterization of the random positioning machine as a microgravity simulator for biological applications
Simulated microgravity platforms provide essential tools for studying gravitational effects on biological systems under controlled laboratory conditions. The Random Positioning Machine (RPM) is among...