PLoS ONE
Articles in this Issue
Insights into spatial dynamics of the microbiome and resistome across the conventional and organic dairy farms
Antimicrobial resistance (AMR) poses a serious global threat to human and animal health. While AMR has been reported in various environments, its distribution across different ecological compartments...
A high-throughput inhibitor screen for the erythrocyte plasma membrane Ca++ ATPase
The ubiquitous and conserved plasma membrane Ca ++ ATPase (PMCA) actively extrudes Ca ++ from eukaryotic cells and maint...
FhlA-mediated regulation of proton transport and energy transduction in Escherichia coli at acidic pH
In Escherichia coli, the FhlA acts as a transcriptional activator for fdhF , hyc...
Clinical validation of automatic phantom-less quantitative computed tomography for osteoporosis screening: fat region of interest comparison and multidevice validation
Background Osteoporosis significantly increases fracture risk and healthcare burden. Traditional bone mineral density screening requires dedicated equipment, limiting opportunistic...
A comparison between bacterial cultivation and 16S rRNA next generation sequencing approaches for analysis of bacteria in urine and cerebrospinal fluid samples
Accurate identification of bacterial pathogens is essential for effective clinical management; however, bacterial diagnosis remains challenging in routine microbiology laboratories, particularly in em...
Broad-spectrum antifungal activity and genome-guided characterization of Paenibacillus polymyxa CACC1094 isolated from the bovine rumen
While Paenibacillus polymyxa is widely recognized for its biocontrol capabilities, most characterized strains originate from soil or rhizosphere environments, l...
Retraction: ISL1 protein transduction promotes cardiomyocyte differentiation from human embryonic stem cells
Correction: Bayesian hierarchical modeling of joint spatiotemporal risk patterns for Human Immunodeficiency Virus (HIV) and Tuberculosis (TB) in Kenya
Patient quality of life determinants in decision-making regarding amputation
Background Psychological adjustment to amputation begins well before surgery and is pivotal in determining both functional and emotional outcomes. For patients with Peripheral Arte...
The role of community capacity building (CCB) in promoting local development: Analyzing leadership in the Hyderabad cantonment community
With leadership positioned as a key tenet, this study investigates the function of Community Capacity Building (CCB) in fostering local development. It combines quantitative survey data from Hyderabad...
STAT-C, an innovative training workshop supporting management of sick leave related to common mental health disorders: A case study for spontaneous scaling in primary care
Background Scaling primary care innovations to benefit broader populations is a key priority for decision-makers. While the science of effective scaling evol...
Outcomes of damage control laparotomy after trauma in low andmiddle-income countries: A systematic review and meta-analysis
Background Damage control laparotomy (DCL) is an established life-saving strategy for critically injured patients presenting with the lethal triad of hypothermia, acidosis, and coa...
The perspectives of individuals with incomplete spinal cord injury on measuring the intensity of balance challenge during reactive balance training: A qualitative study
Importance Balance rehabilitation is an important component of recovery for individuals with incomplete spinal cord injury (iSCI), who are at heightened risk of falls due to impair...
Deciphering intercellular communication in the cerebellar external granule layer: Insights into non-classical connections in neural development
Intercellular communication is essential for brain development. While classical modes—paracrine, juxtacrine, and synaptic signaling—are well characterized, emerging evidence suggests that membranous b...
How gender is associated with physical bullying and victimization across adolescent stages
Background Physical bullying remains a significant form of peer aggression during adolescence, a developmental period marked by rapid bodily, psychological, and social change. Alth...
Early potential safety signals for gliptins and gliflozins using real-world pharmacy data compared to spontaneous reporting
Background Dipeptidyl peptidase 4 inhibitors (DPP4i, gliptins) and sodium-glucose co-transporter 2 inhibitors (SGLT2i, gliflozins) are two oral antidiabetic drug classes that have...
Embedding a primary care provider in sickle cell teams improves sickle cell care
Adults with sickle cell disease (SCD) experience fragmented access to primary and preventive care, which leads to poor adherence to general and SCD‑specific clinical practice guidelines. To address th...
Design and evaluation of a novel fusion antigen for diagnosing human strongyloidiasis: An immunoinformatics approach
Strongyloidiasis, caused by Strongyloides stercoralis , remains a neglected tropical disease (NTD) with significant clinical implications, particularly in immun...
Steps against the burden of Parkinson’s disease (StepuP): Protocol of a randomized controlled trial elucidating the biomechanical and neurophysiological mechanisms of a speed dependent treadmill training intervention
Objective Parkinson’s disease can impair gait and stability, leading to reduced independence and increased fall risk. While speed dependent treadmill training (SDTT) is clinically...
Impact of long-term cryopreservation on serum proteome and metallome: Implications for Biobank quality control
Biobanks constitute a cornerstone of modern biomedical research, yet the effects of long-term storage on biospecimen integrity are not fully characterized. This study systematically evaluated the impa...
Demonstrating conservation impacts in California Marine Protected Areas using large-scale participatory science data
Measuring human interactions with protected areas is a key need in conservation social science, both to assess the potential for continuing negative impacts on sensitive resources and to support posit...
Transformer-based advertisement image layout generation and object fidelity optimization
The layout of the image and the positional distribution of the objects directly affect the audience’s visual focus and the effect of the message conveyed. By setting up a specific layout structure, th...
Medicaid expansion and inpatient hospital charges among women with major depressive disorders
Objective To examine the association between Medicaid expansion under the Affordable Care Act (ACA) and total inpatient hospital charges among women hospitalized with major depress...
Association between unhealthy snack food and beverage consumption and the nutritional status of Nepalese children and adolescents: A systematic review
Introduction Eating habits have changed significantly over the past few decades, with consumers favoring unhealthy snack foods and beverages over traditional foods. This trend has...
Influence of environmental factors on the spat recruitment of the eastern oyster (Crassostrea virginica) along a subtropical river estuary in the Gulf of Mexico
Oyster spat recruitment is a key process controlling the persistence of natural populations. However, the relative influence of environmental gradients on spat recruitment remains poorly understood in...