Few-shot skin lesion classification with Adaptive Multi-Scale Convolutional Attention Network

H HuiYing Jin E E. Liu Q Qin Xu Y Yuchen Li X Xiaoliang Chen (State Key Laboratory of Synergistic Chem-Bio Synthesis, State Key Laboratory of Micro-Nano Engineering Science, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine) W Weihua Chen

Abstract

Computer-aided diagnosis of skin lesions faces core challenges, including scale diversity, blurred boundaries, intra-class morphological variations, and sparse data. Existing methods often rely on fixed receptive fields or generic attention mechanisms, struggling to fully adapt to the unique characteristics of skin lesions. To address this, we propose an Adaptive Multi-scale Convolutional Attention Network (AMCANet), which aims to achieve accurate and robust classification of skin lesions with limited data. AMCANet comprises three core modules: the adaptive multi-scale convolution module dynamically adjusts the receptive field to accommodate lesions of varying sizes; the hierarchical channel attention module integrates multi-level semantic information across different resolutions; and the skin spatial attention module leverages image gradient information to enhance lesion boundaries and local texture features. Extensive few-shot experiments on the HAM10000 and PAD-UFES-20 public datasets demonstrate that AMCANet significantly outperforms existing baseline models across multiple metrics, exhibiting promising generalization capabilities on the evaluated datasets. Qualitative and visual analyses further validate the model’s ability to extract discriminative features and effectively focus on lesion regions. This study proposes a deep learning model, which demonstrates certain effectiveness in classifying skin lesions even with a small number of samples, providing a potential direction for future research.

Article Details

Journal PLoS ONE
Volume / Issue Vol. 21, Issue 6
Published June 25, 2026
Pages e0351318
ISSN 1932-6203
Publisher Public Library of Science

Journal Info

PLoS ONE

Public Library of Science

ISSN: 1932-6203 Open Access Health Sciences

Authors (6)

H

HuiYing Jin

E

E. Liu

Q

Qin Xu

Y

Yuchen Li

X

Xiaoliang Chen

State Key Laboratory of Synergistic Chem-Bio Synthesis, State Key Laboratory of Micro-Nano Engineering Science, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine

W

Weihua Chen