PLoS ONE
Articles in this Issue
Body fat, skin tone, and the accuracy of smartwatch caloric expenditure estimates
Smart watches are commonly used to provide continuous feedback on activity and caloric expenditure and are leveraged for weight management, clinical decisions, and public health strategies. Most wrist...
Mapping the chaperonin TRiC/CCT interactome in mouse photoreceptors reveals functional significance for energy metabolism
The eukaryotic chaperonin TRiC/CCT is essential for folding a diverse set of proteins, yet its interactome and functional roles in specialized neurons remain incompletely understood. To investigate TR...
Quantitative comparative study on the verb-direction constructions “V+ Xia (下)”, “V+ Xialai (下来)” and “V+ Xiaqu (下去)” in mandarin Chinese
“V+ Xia (下)”, “V+ Xialai (下来)” and “V+ Xiaqu (下去)” are common verb-directio...
Optimization of CNC milling parameters for YXR-7 tool steel using fuzzy MARCOS: A multi-response approach to improve machining productivity
This study presents an integrated optimisation method for CNC milling of heat-treated YXR7 tool steel using carbide cutting inserts under varying lubrication and process parameters. A full factorial e...
Investigating the adaptive coping mechanisms of rewilded elephants: A comparison of behavioural and physiological variables with wild elephants
Literature on the adaptability and environmental processing abilities of ex-captive (rewilded) African elephants ( Loxodonta africana ) is sparse, emphasising t...
The comparative analysis of Sino-Japanese football policies from the perspective of policy instruments
Football development depends heavily on strong policy support, rendering policy analysis and evaluation of significant practical importance. This study uses Nvivo11 software and the PMC index model to...
Pattern of opioid prescriptions among patients with breast, lung, and colorectal cancer diagnosed with pre-existing chronic non-cancer pain
Background Chronic non-cancer pain (CNCP) due to comorbid conditions presents a barrier to optimal pain management in patients with cancer. While opioid is widely used for the trea...
Examining the joint impact of missing data mechanisms and item parameter drift on the accuracy of item response theory-based test equating
Maintaining score comparability across different test administrations is essential in large-scale educational and psychological assessment. Two major threats to equating accuracy are item parameter dr...
Dual biocontrol and osmotic stress mitigation by endophytic Aspergillus micronesiensis and Penicillium momoi against fusarium pathogens
Global challenges associated with crop diseases and abiotic stress necessitate sustainable agricultural solutions. This study investigated the biocontrol and osmotic-stress mitigation potential of two...
Systematic multi-parameter optimization of an injectable thermosensitive CS/β-GP/HEC hydrogel for 3D cell culture applications
Injectable thermosensitive hydrogels have been widely investigated as minimally invasive scaffolds for three-dimensional (3D) cell culture. In this study, we systematically screened a chitosan (CS)/β-...
Efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin and anemia in the pediatric population: A systematic review and meta-analysis
Aim To evaluate the efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin levels and anemia in the pediatric population....
General healthcare preferences for people aged 50 and over in England: English longitudinal study of ageing
Background Treatment outcomes and satisfaction improve when healthcare decisions align with patient preferences. However, little is known about general health preferences in older...
Pronunciation assessment in foreign language learning: Reliability and scoring bias in human–generative AI evaluation
This study examines the reliability and scoring bias of generative AI (Gen-AI)-based pronunciation assessment compared with human raters, addressing whether AI-generated scores can be trusted in real...
From productive landscape to cultural space: The heterogeneous coupling of heritage value perception and tourist experience demand in the Grand Canal Cultural Route
In the context of rapid urbanization, the transformation of linear hydraulic heritage from productive landscapes to high-quality cultural spaces is a pivotal issue for sustainable development. Taking...
Tracing early life stress in human molar morphology: Associations between linear enamel hypoplasia and maxillary first molar form
Permanent tooth structures can respond to environmental disruptions even after the initiation of hard tissue deposition at the cusp tips, affecting dental morphology. In bioarcheological studies, line...
Dopaminergic genetic variation and response to social comparative feedback when learning a motor sequence task
Positive social comparative feedback during motor skill practice is hypothesized to enhance motor learning by triggering a dopaminergic response. Individual differences in dopamine-related genes impac...
Computational analysis reveals historical trajectory of East Polynesian lunar calendars
We investigate a type of lunar calendar known as lists of the ‘nights of the moon’, found throughout East Polynesia, including Rapa Nui (Easter Island). Using computational methods, we analyzed the le...
Drug use patterns at a Kenyan referral hospital: A cross-sectional study using WHO core indicators
Background Suboptimal medicine use practices remain a major global health challenge, particularly in low- and middle-income countries, where it contributes to increased healthcare...
Procedural or declarative deficit in adults with developmental dyslexia? A study of Artificial grammar learning
Artificial grammar learning (AGL) has frequently been employed to investigate the procedural hypothesis of dyslexia. However, most studies did not distinguish whether performance depended upon the acq...
Formulation development of a biphasic release tablet-in-tablet system containing ketorolac tromethamine
Ketorolac tromethamine (KT) is a potent nonsteroidal anti-inflammatory drug (NSAID) used for moderate to severe pain management. Its short elimination half-life necessitates frequent dosing, which can...
Object detection in histology: A multi-dataset benchmark and test-time inference
Medical image analysis has become increasingly important for automated medical diagnosis, as well as deep learning. Specifically, object detection models may help in automatically identifying patholog...
Gene-transcription factor regulatory networks implicate primary cilia in the evolution of vertebrate sex determination and expand models of epigenetic regulation
The molecular architecture underlying diverse vertebrate sex-determining systems remains elusive despite fragmentary evidence of changes in upstream regulators and downstream mediators. Here we modele...
Supporting recovery: Intersections of health, belonging, and help seeking after a campus mass casualty event
Mass casualty events (MCE), such as campus shootings, can severely impact the mental health of students, faculty, and staff. This study examined the psychological effects of an MCE at a minority-servi...
iNaturalist mammal observations classified by evidence type
Ecologists show growing interest in observational data generated by citizen scientists. For mammals, the largest citizen science platform is iNaturalist, which has more than 5 million Research Grade o...
Healthcare providers' perspectives and needs related to the management of Pediatric Feeding Disorder: A focus group study
Pediatric feeding disorder is a prevalent, impactful diagnosis for children and their families. This diagnosis is heterogenous in presentation and requires the care of a multidisciplinary team of prov...