PLoS ONE
Articles in this Issue
Suicidal ideation, mental health services, and barriers to care among syringe services program clients who use opioids
Introduction People who use opioids (PWUO) experience a disproportionately high burden of suicidal risk. Syringe services programs (SSPs) are a critical point of contact for this p...
PM-DUnet: Fusing long-range dependencies and attention in a dual-U architecture for thyroid nodule segmentation
For medical image segmentation, accurately balancing local details and global long-range dependencies is critical to tackling thyroid nodule challenges (variable sizes, ambiguous boundaries, complex c...
Analysis of the characteristics of spino-pelvic sagittal parameters in Degenerative Thoracolumbar Kyphosis deformity and the mechanism of sagittal imbalance
Background Degenerative thoracolumbar kyphosis (DTLK) is a subtype of adult spinal deformity. If DTLK progresses further, it can develop into global kyphosis (GK). Although numerou...
The mediating role of sleep quality in the association between urinary incontinence and depressive symptoms: A study with older Korean Americans Living in Subsidized Senior Housing
Urinary incontinence (UI) is a prevalent health issue among older adults. Depressive symptoms often accompany UI; however, the pathways linking these conditions remain understudied. In this study, we...
Lessons learned from youth-engaged research methods to conduct qualitative analysis with a transgender and gender-diverse youth advisory board
Although community-engaged research is becoming more common, youth-engaged research methods, particularly its application to qualitative analysis, remains rare. The Research on Identity Specific Eatin...
Third- and concerned-party positions in moral dilemmas: Effect of empathy on ethical judgment
The present study proposes a categorization of moral dilemmas into third-party dilemmas in which a judge’s choice affects only the life or death of others, and concerned-party dilemmas in which not on...
Socioeconomic equity in maternal health services use in Bangladesh: The role of service readiness in health facilities during the period 2001–2016
Background Equity in health service utilization refers to equal treatment for equal health needs, regardless of socioeconomic status. In low- and middle-income countries, inequity...
Longitudinal omics study of transcriptional dynamics in Lactobacillus crispatus
Background The vaginal microbiome is an important component of female reproductive health. Community State Type I (CST-I), which is dominated by...
Assessing the investment risk: An empirical analysis of Altman’s Z-score model
Investors can play a significant role in reviving the economy and addressing the national agenda of poverty elimination through job creation. Though foreign and local investment are the backbone of an...
Mechanistic evaluation of NSC 57774 as a SHP2 inhibitor in gastric cancer: Multi-pathway signaling modulation in vitro
Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, driven by late-stage diagnosis, metastatic progression, and therapeutic resistance. Src homology region 2 domain-cont...
Field evaluation of 3-(N-acetyl-n-butyl) aminopropionic acid ethyl ester - IR3535 as a spatial repellent to control malaria: A Randomised, Before-After-Control-Intervention trial
Background Malaria remains a major public health challenge in sub-Saharan Africa. Increasing mosquito resistance to insecticides can significantly limit current vector control stra...
Leveraging expression quantitative trait loci information in single-cell resolution to identify cell-specific genes for gestational diabetes
Background Gestational diabetes mellitus (GDM) is a common pregnancy complication with long-term metabolic consequences for both mother and offspring. While genome-wide association...
Predicting medication non-adherence using machine learning: Incorporating Complementary and Alternative Medicine (CAM) beliefs in Malaysian chronic disease patients
Medication non-adherence among chronic disease patients remains a major contributor to poor health outcomes and medication wastage, particularly in multi-ethnic populations such as Malaysia where cult...
Methicillin-resistant Staphylococcus aureus (MRSA) infection in hospitalized patients is dominated by community-acquired strains: genomic epidemiological evidence
Objective This study aimed to systematically investigate the molecular epidemiological characteristics of methicillin-resistant Staphyl...
High-accuracy pseudospectral scheme for fractional diffusion-wave problems based on cardinal functions
Fractional diffusion-wave equations (FDWEs) are essential for modeling complex physical phenomena with memory and hereditary properties, such as anomalous diffusion and viscoelasticity, which classica...
Association between anthropometric measures and abdominal wall thickness in patients with obesity: A cross-sectional CT study
Background Abdominal wall thickness (AWT) is a critical determinant of safe abdominal access in patients with obesity, yet it is not routinely assessed preoperatively. Simple, beds...
Evaluation of a tele-refraction model to address the lack of human resources in Kenya
Background Uncorrected Refractive Errors (URE) constitute a significant public health concern in Kenya, where limited availability of qualified eye care professionals continues to...
EEG spectral biomarkers of postoperative delirium in spinal surgery: A high-resolution analysis
Background Postoperative delirium is common in older adults following spinal surgery, yet current EEG-based detection methods rely on broad conventional frequency bands that may ob...
A comparative study of Korean and Chinese learners’ strategy use in request-refusal continuous dialogue speech acts
In daily communications, the use of speech acts that may threaten others’ faces, such as request and refusal, is inevitable. By methods of DCT with 24 coherent request-refusal scenarios as well as opt...
Bioassay-guided isolation of antioxidant, antibacterial, and antidiabetic compounds from Aleuritopteris bicolor of Nepal: In vitro/in silico study
Aleuritopteris bicolor , a fern species known locally as “Raani Sinkaa” in Nepal, has traditionally been used to treat wounds, diarrhea, dysentery, and gastritis. Despite its wides...
Psychometric properties of the Arabic Perceived Digital Well-Being Scale (PDWS) in Saudi young adults
Rapid digital transformation in Saudi Arabia has intensified young adults’ day-to-day reliance on smartphones, increasing the need for balanced, culturally appropriate measures of perceived digital we...
Diagnostic yield and complication rate of transbronchial lung cryobiopsy using 1.1 mm probe in patients with interstitial lung disease
Background Widespread adoption of transbronchial lung cryobiopsy (TBLC) using a 1.9 or 2.4 mm touch cryoprobe in interstitial lung disease (ILD) has been limited by high bleeding r...
Integrating smoking cessation into HIV care settings: A systematic review and meta-analysis of effectiveness and the evidence gap in cost-effectiveness
The prevalence of smoking among people living with HIV (PLWH) is higher than in the general population, and PLWH who smoke are at increased risk of both smoking- and HIV-related comorbidities. As most...
Influence of a complex mycotoxin detoxifier on growth performance, liver health, inflammation, and redox status of broilers fed a diet contaminated with multiple mycotoxins
This study investigated the effects of a complex mycotoxin detoxifier (CMD) on growth performance, liver health, inflammation, and redox status of broilers fed a diet contaminated with multiple mycoto...
Efficient hybrid algorithm for nonnegative matrix factorization based on modified nonmonotone linear search
In this paper, we present a modified nonmonotone line search algorithm that employs a variable parameter to control the degree of nonmonotonicity. This modification enhances both the probability of id...