PLoS ONE
Articles in this Issue
Navigating the potassium dilemma: a qualitative study of nephrologists’ strategies for renin–angiotensin–aldosterone system inhibitor preservation and hyperkalaemia management in Spain
Background Hyperkalaemia is a common complication among patients with predialysis chronic kidney disease (CKD) and a leading reason for modifying or discontinuing renin–angiotensin...
Environmental footprint of in-center hemodialysis in Türkiye: A national, scenario-based analysis of water, energy, and waste
Background Hemodialysis (HD) is a life-sustaining but resource-intensive therapy, consuming large volumes of water and electricity and generating substantial waste. This hybrid mod...
Exploratory identification of candidate SNP markers associated with recurrent clinical mastitis in Holstein cattle
Mastitis remains one of the most prevalent and economically significant diseases in dairy cattle worldwide. Although somatic cell count (SCC) is widely used as an indicator for mastitis diagnosis, its...
Structural analysis of recombinant AAV vector genomes at single-molecule resolution
Recombinant adeno-associated virus vectors are essential tools for in vivo gene therapy, yet heterogeneity in their packaged genomes remains an important safety...
Effectiveness of MyKidEye in improving parents’ knowledge, attitude, and practice on children eye health care
Background Vision problem among children is the most common health concern worldwide. Parental involvement plays an important role in addressing these issues especially through the...
Directional drift in biologically meaningful vector planes: A proposed geometric framework for early detection of subthreshold disease
Background Most conventional diagnostic systems rely on fixed thresholds to differentiate disease states from normal. However, early pathological changes may begin before these thr...
Design and validation of an immersive virtual rehabilitation system for individuals with vestibular disorders: A feasibility study
Background Vestibular rehabilitation is an essential part of managing balance disorders, but traditional exercises can often be repetitive and demotivating for patients. This can r...
Retailer’s inventory-based financing with bounded advance rates: Interplay between wholesale price contract and loan menu
We examine a supply chain comprising a capital-constrained retailer, a supplier, and a bank. The retailer adopts inventory-based financing with bounded advance rates (IBF-B) to procure products throug...
Bayesian hierarchical mixture modelling to derive probabilistic iELISA thresholds for bovine brucellosis in endemic dairy systems
Background In endemic dairy systems, the interpretation of serological tests for bovine brucellosis is compromised using fixed diagnostic cut-offs, which fail to account for contin...
Association of troponin-defined myocardial injury with adverse long-term survival among patients with chronic kidney disease
Objective Chronic kidney disease (CKD) is associated with increased mortality, however, the impact of troponin-defined myocardial injury within this population remains poorly under...
An innovative quantum–fuzzy paradigm for time- and context-sensitive membership: Quantive logic
Uncertainty in real-world decision problems is rarely static or one-dimensional: the relevance of evidence changes over time, depends on context, and is shaped by interactions between multiple criteri...
Assessing the effects of virtual reality-based positive psychotherapy on emotion, life satisfaction, and suicidal ideation in major depression: A mixed-methods randomized controlled trial
Background Positive psychotherapy (PPT) targets the enhancement of well‑being in individuals with major depressive disorder (MDD), and virtual reality (VR) offers an immersive medi...
Overexpression of CD97 in intestinal epithelial cells attenuates LPS-induced pro-inflammatory cytokine induction via stabilization of β-catenin early in life
Acute inflammatory conditions in the intestine of preterm infants are linked to increased susceptibility due to the immature degree of the gut’s epithelial barrier, microbiota, and pattern recognition...
The promise of deep urine proteomics for diagnosis of cancer, neurologic, and metabolic diseases
Introduction Urine offers a noninvasive and low-cost source of disease biomarkers, yet most proteomic studies have targeted single conditions. Using deep proteomic profiling and ma...
Explaining the reasons for the divorce of young couples in Western Iran: A qualitative Study from the Beneficiary's point of view
Divorce is an important social issue that has destructive consequences for both the individual and the family. It is a multi-dimensional and complex phenomenon that occurs under the influence of vario...
Depressive symptoms among older adults in Turkey: Evidence from a nationally representative ageing survey
Background Late-life depression is a growing public health issue in ageing societies, influenced by health, functional, socioeconomic, and psychosocial factors. Evidence integratin...
Walking the tightrope of justifiable decision‑making: An exploratory qualitative study identifying barriers and solutions to efficient safety reporting
Background Safety reporting is integral to clinical trial conduct, aiming to protect the rights and safety of trial participants and future patients. Over time, reporting safety ev...
Educational strategies to improve health literacy for people with type 2 diabetes in low socio-economic communities: A realist review protocol
Introduction Type 2 diabetes (T2D) has emerged among the top ten causes of disability and mortality worldwide. Health literacy is crucial for effective self-management to reduce th...
Development of a scale for measuring the perception of artificial intelligence among mental health consumers
Background Artificial Intelligence (AI) has emerged as a transformative force revolutionizing various sectors, including healthcare, particularly the mental health field. However,...
How antiretroviral data cleaning reshaped Mozambique’s progress to reaching HIV epidemic control
Quality data is fundamental for any public health program, especially for long-term care programs that rely on longitudinal data for decision making. In Mozambique, there had been a growing discrepanc...
A designathon to collaboratively develop sustainable HIV prevention services for youth with community-based organizations in Nigeria
Introduction The engagement of youth in the design of services that promote and increase the uptake of essential services to reduce HIV and other sexually transmitted infections is...
Real‑world analysis of Macular Oedema associated with Paclitaxel Formulations using the Japanese Adverse Drug Event Report database
Aim This study explored the potential association between paclitaxel (PTX) and macular oedema (ME), a rare adverse event, through pharmacovigilance analysis using a large-scale spo...
A comparative analysis of readability, quality, and reliability in large language model outputs pertaining to knee osteoarthritis queries
This study aims to comparatively examine the readability, accuracy, and quality of responses provided by artificial intelligence (AI)-based chatbots such as Perplexity, ChatGPT-5, and Gemini to questi...
Neck circumference as an anthropometric marker of overweight among school-aged children in Bharatpur, Nepal: A community-based study
Background Childhood overweight have become a major public health concern among children in developing countries. BMI, commonly used to diagnose overweight, requires standardized e...
Temptation as a key driver between affective states and usage outcomes of problematic usage of the Internet: A 14-day ambulatory assessment study
Theoretical models of problematic usage of the Internet (PUI) assume that stress and negative mood can trigger cravings and desires as central drivers to use certain online applications that are expec...