PLoS ONE
Articles in this Issue
DiSCoKit: An open-source toolkit for deploying live LLM experiences in survey research
In scientific studies of human-AI interaction dynamics, researchers often need to present participants with opportunities to interact with live large-language models (LLMs). However, technical and pra...
It would be really great if I had greater confidence and ability there: Understanding the primary care physician experience with nutrition in training, clinical practice, and interprofessional collaboration
Background Primary care physicians (PCPs) are on the front lines of health promotion and disease prevention, yet evidence supports a longstanding gap in physicians’ capacity to cou...
Bacterial vaginosis in early pregnancy and birth outcomes: Evidence from a prospective cohort in the middle belt of Ghana
Background Bacterial vaginosis (BV) is highly prevalent in women of African origin and has been associated with adverse birth outcomes (ABO), particularly preterm birth (PTB). Howe...
Concordant RNA-protein evidence and human tissue metabolomics prioritize UPP1-associated nucleotide remodeling in prostate cancer
Prostate cancer (PCa) is characterized by molecular heterogeneity and metabolic reprogramming, but the relationships among transcriptomic, proteomic, and metabolic signals remain incompletely defined....
A cross-domain deep learning framework for remaining useful life prediction in industrial applications
Accurate prediction of Remaining Useful Life (RUL) is critical for predictive maintenance and minimizing downtime in industrial systems. This paper presents a cross-domain deep learning framework base...
The analgesic effect of ultrasound-guided fascia hydrorelease around the artery for myofascial neck pain: a prospective single-arm interventional study
Myofascial pain syndrome (MPS) is a major cause of chronic neck pain, with tissue ischemia implicated as a contributing factor. This prospective, single-arm interventional study evaluated the analgesi...
Functional node layout in Metroidvania game worlds: A complex network analysis
This study investigates how the spatial structure of Metroidvania game worlds relates to the layout of key functional nodes. Using Hollow Knight, Prince of Persia: The Lost Crown, and Blasphemous 2 as...
Fecal carriage of ESBL and Carbapenemase-producing Enterobacteriaceae, and its associated factors among hospital and non-hospital janitors at the University of Gondar, Northwest Ethiopia: A comparative cross-sectional study
Background Extended-spectrum beta-lactamase (ESBL) and carbapenemase-producing Enterobacteriaceae (CPE) pose a critical public health threat. Janitors are routinely exposed to cont...
Catastrophe mechanism and early warning indicators of seepage erosion-induced water inrush in karst cavities
Seepage-erosion-induced water inrush in karst cavities is a typical form of water-inrush disaster in karst tunnels. It is governed not only by the spatial distribution of karst cavities and hydraulic...
A computer vision-based approach for automatically extracting data from bar chart raster images to facilitate meta-analysis of biomedical literature
Although bar charts are widely used in scientific publications, their rasterized format within Portable Document Format (PDF) files complicates automated data extraction, hindering large-scale evidenc...
Real-world regorafenib use among patients with advanced gastrointestinal stromal tumor in the United States
Background Gastrointestinal stromal tumors (GIST) are the most common gastrointestinal soft tissue sarcoma. Tyrosine kinase inhibitors are guideline-recommended therapy; however, r...
Heat stress-induced photosynthetic impairment and autophagy modulation in Paris polyphylla var. yunnanensis: A physiological and molecular Perspective
High temperature is one of the major environmental stressors that severely affects plant growth. Paris polyphylla var. yunnanensis...
Analysis of the work, health and well-being experience of immigrant personal support workers in minority language contexts in Canada: Scoping review protocol
Background The aging Canadian population has led to an increase in Canada’s use of home and community care services. In this context, the healthcare system relies heavily on person...
Veterinarian–pharmacist collaboration in veterinary medicine: Roles, practices, and perceptions—A scoping review
Background Pharmacists are expanding their participation in veterinary healthcare teams and assuming roles beyond traditional dispensing duties. However, the scope of these collabo...
Morphological and molecular characterization of Nepalese Common Bean (Phaseolus vulgaris L.) Landraces
Nepalese common bean landraces constitute valuable yet underexplored genetic reservoirs for crop improvement. However, integrated morphological and molecular characterization of this germplasm remains...
Verbascoside triggers apoptosis and ferroptosis in NSCLC by targeting BCAT2
Background The treatment of non-small cell lung cancer (NSCLC) has challenges such as drug resistance and recurrence. Concurrently, the induction of apoptosis and ferroptosis is a...
Genomic epidemiology of Group B Streptococcus colonization among pregnant women in Japan, 2021–2023
Group B Streptococcus (GBS) colonization in pregnant women is a major risk factor for neonatal diseases; however, molecular epidemiological studies on GBS in Ja...
Prevalence and anatomical distribution of incidental and actionable findings on CBCT scans for implant planning
Objectives To determine the prevalence and anatomical distribution of incidental (IF) and actionable findings (AF) on cone-beam computed tomography (CBCT) scans obtained for dental...
Current clinical practices in pediatric audiology among audiologists in India
Objective Evidence-based practice is central to audiology; however, adherence to best-practice guidelines varies, particularly in pediatric settings. This study explored current pe...
You “can’t get away from the social”: Individual, relational, and contextual influences on mental health and substance use-related help-seeking among people in contact with the criminal justice system
Rationale People in contact with the criminal justice system outside institutional settings have high levels of mental health and substance use problems, contributing to adverse ou...
Radiographic legal age estimation based on third molar development using Machine-learning algorithms
Background Age assessment plays an important role in forensic sciences to aid in criminal or civil matters. Third molars continue developing during the legal age of adulthood. Dent...
Determinants of parental traditional medicine use for children during COVID-19 in Dire Dawa city administration, Eastern Ethiopia, 2023/24: Mixed community based cross-sectional study design
Introduction Globally, 85% of the population uses traditional medicine. Ethiopia is a country with various traditional medicinal practices. However, various studies also reported t...
Acid-activated chitosan-modified Iranian bentonite for adsorption of Cu(II) and Zn(II) from water; A green and sustainable water treatment approach
This study evaluates the adsorption performance of an Iranian bentonite modified through two routes: activation with HNO 3 followed by calcination at 500 °C yie...
From manual counting to YOLO: Using computer vision to automate large-scale fecundity assays in C. elegans
Fecundity measurements play a crucial role in life history research, providing insights into reproductive fitness, population dynamics, and environmental responses. In the model nematode...
Growing up without violence (GWV): Results of a cluster randomised trial of a school-based intervention preventing adolescent sexual abuse and exploitation in Brazil
Introduction Child sexual abuse and exploitation (CSAE) are pervasive problems that significantly affect the health of children and adolescents. This paper presents the results of...