PLoS ONE
Articles in this Issue
Theoretical assessment design at a South African school of nursing: A multimethod qualitative exploration
Introduction Theoretical assessment design is crucial in nursing education, ensuring students develop cognitive and problem-solving skills for clinical practice. However, misalignm...
Reconstructing IDF curves from daily rainfall records in data-scarce regions: A statistical method based on temporal disaggregation and gumbel modeling
Urban regions in the tropics often face challenges in hydrological design due to the lack of high-resolution rainfall data. This study presents a method for generating intensity, duration, frequency (...
Genetic yield of next-generation sequencing for detecting monogenic familial hypercholesterolemia in uzbek patients with coronary artery disease
Background Familial hypercholesterolaemia (FH) is an inherited disorder with markedly elevated LDL-C and increased risk of premature atherosclerotic cardiova...
A multi-objective portfolio optimization model incorporating sentiment analysis of quarterly reports and LSTM-based price prediction
Sentiment analysis (SA) of natural language text has become as a powerful instrument for enhancing financial market predictions. Quarterly reports from companies, in particular, offer a rich source of...
An integrated multi-omics study of key mediators and therapeutic targets for doxorubicin-induced atrial fibrillation
Background Doxorubicin (DOX), a widely used chemotherapeutic agent for cancer patients, is associated with a significant risk of inducing atrial fibrillation (AF), a serious cardia...
Effect of sex hormones, garlic and fennel extracts in layers’ breeders diet on inherited offspring sex
This study aimed to examine the effect of dietary supplementation with sex hormones, garlic, and fennel extracts in layer breeders on the molecular sex ratio of their progeny. One hundred layer breede...
Machine learning for predicting emergency department visits in patients with type 2 diabetes: A real-world, multi-institutional study
Background Patients with type 2 diabetes mellitus (T2DM) prone to acute diabetic complications are at high risk for emergency department (ED) visits, which often precede hospitaliz...
Dysregulated glucocorticoid-responsive immune genes in peripheral blood mononuclear cells as a shared molecular signature of autism spectrum disorder and irritable bowel syndrome
Background Autism spectrum disorder (ASD) is frequently accompanied by gastrointestinal (GI) disturbances resembling irritable bowel syndrome (IBS). While dysregulation of the hypo...
Cloacal microbiome variation in wild and captive Eastern Indigo Snakes (Drymarchon couperi) with and without Cryptosporidium serpentis infection
The Eastern Indigo Snake (EIS; Drymarchon couperi ), a federally threatened species native to the southeastern United States, serves as a valuable model for exa...
Evaluation of tri-plate rapid on-farm culture system to make therapeutic decisions for mastitis cases in dairy cattle
The empirical use of antibiotics for clinical mastitis is a principal driver of antimicrobial resistance in dairy farming. While on-farm culture systems represent a promising strategy for targeted the...
Predicting the finished fabric width and areal density (Grams per Square Meter) of commercially produced plain Single Jersey (100% Cotton) Knitted Fabric using Fuzzy Inference System (FIS)
The purpose of this research is to predict Finished Fabric Width (FW) & Areal Density (GSM) of 100% cotton plain single jersey knitted fabric by building a fuzzy inference model incorporating key...
Sodium Bicarbonate versus N-Acetylcysteine plus hydration versus hydration alone for preventing contrast-associated acute kidney injury: A single-center retrospective analysis with propensity score matching
Background Contrast-associated acute kidney injury (CA-AKI, historically termed contrast-induced nephropathy, CIN) is a leading cause of iatrogenic acute kidney injury (AKI) follow...
Interactions between self-help and hospice and palliative care – Opportunities, barriers and needs (Self-Pall): A study protocol
Introduction A progressive and life-limiting disease can cause enormous psychological distress for patients and family caregivers. Health-related collective self-help could be a co...
Amyloid-bodies in the evolution of malignancies
Tumorigenesis depends on the capacity for cancer cells to survive in the presence of various environmental stressors. An emerging paradigm in the study of cancer cell stress responses is their regulat...
Contextual image caption creation using object positional embedding and generative models
Automated image captioning remains a challenge, as it enables machines to generate context-aware textual descriptions of visual content. Traditional deep learning approaches often rely on lexical over...
Serological evidence of SARS-CoV-2 exposure in marine mammals in the United States between 2020 and 2025
Natural infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been documented in over 60 animal species, some distantly related. Several marine mammals have been predicted as...
Modelling and simulation of smart city drainage system based on digital twin five-dimensional models
The construction of smart cities has entered a new stage of industrial development in light of the industrial revolution. The aim is to create digital twin cities that integrate the dual systems of ph...
Mycobacterial lipoarabinomannan negatively interferes with macrophage responses to Aspergillus fumigatus in-vitro
Over 1 million people have chronic pulmonary aspergillosis (CPA) secondary to pulmonary tuberculosis. Additionally, Aspergillus fumigatus (...
A practical inflammatory blood-cell marker for cardiovascular risk stratification in psoriasis: Development of the Platelet-Leukocyte Adjusted Cardiovascular (PLAC) score
Background Psoriasis is an inflammatory disease associated with atherosclerotic cardiovascular disease (ASCVD). Although blood-cell markers predict ASCVD in the general population,...
Full blood count dynamics in immunologically naïve individuals with mild COVID-19: A prospective community cohort study
Purpose Full blood count (FBC) provides a range of cellular haematological parameters and serves as a routinely available basic immune profile. While FBC has been widely used to mo...
Self-positioning in space science communication: A corpus-assisted discourse study
This study incorporates text mining into critical discourse analysis to examine how government science agencies in China and the United States position themselves in space science communication on soc...
Early life stress enhances the association between residential nature exposure and fasting blood glucose
Background Emerging epidemiological evidence indicates that groups in low socioeconomic positions exhibit more pronounced health benefits from nature exposure compared to more priv...
Metataxonomic insights into lactic acid bacteria diversity in artisanal coalho cheese from the Caatinga biome
Artisanal raw-milk cheeses are complex microbial ecosystems that reflect local environments through spontaneous fermentation driven by lactic acid bacteria (LAB), processing practices, and the quality...
Parental knowledge, vaccine hesitancy, and practices regarding seasonal influenza vaccination for preschool-aged children in Shenzhen, China: Insights from a cross-sectional survey
Background Seasonal influenza poses a substantial health threat to children under 5 years of age. Despite recommendations for annual seasonal influenza vaccination (SIV), coverage...
Prevalence, diagnostic methods, and clinical outcomes of wasting among paediatric cancer patients in Africa: A systematic review and meta-analysis
Background Malnutrition is a prevalent and modifiable co-morbidity in paediatric oncology, yet no comprehensive pan-African synthesis of its burden has been conducted. This systema...