PLoS ONE
Articles in this Issue
Individual differences and motives for the acceptance of cognitive enhancement: A mixed-methods investigation
Despite a long history of human efforts to enhance cognitive abilities such as attention, memory, and intelligence, the proliferation of (new) technological and medical methods—including brain stimula...
ProbStab: A probabilistic ML-assisted pipeline for genotype performance, stability, and risk evaluation in multi-environment trials
In multi-environment trials (MET), ignoring genotype × environment interaction (GEI) can lead to suboptimal cultivar recommendations and increased risk in breeding decisions. To make informed decision...
The specificity of psychotherapeutic competence: A study protocol on the development of facilitative interpersonal skills across professional pathways
Introduction Facilitative interpersonal skills (FIS) are widely used as an operationalization of therapists’ interpersonal competence. However, the degree to which FIS are specific...
The effect of motivational determinants on elite Wrestlers’ ıntentions to continue in sport: The mediating role of enjoyment
This study aimed to examine the associations of motivational determinants, including goal orientation, satisfaction of basic psychological needs, and motivation, with elite wrestlers’ intention to con...
Design and validation of a key performance indicator dashboard for equity in community and retail pharmacy services in Pakistan
Background Community and retail pharmacies are essential to primary healthcare delivery in Pakistan; however, significant disparities in workforce distribution, medicine availabili...
Three-dimensional seismic response analysis of connected structures with damping layers
To enhance the seismic damping effect of connected structures under intense seismic activities, this study introduces a novel control system for connected structures. This system strategically places...
Vegetation-based slope protection using bermuda grass: Effects on the dynamic elastic modulus of weakly expansive soil
Weakly expansive soil is utilized in subgrades and slope engineering. vegetation is commonly adopted for ecological reinforcement, and its effects on the dynamic mechanical behaviors of weakly expansi...
Editorial Note: Why are they eco-friendly? Attributing eco-friendly descriptive norms to intrinsic motivation increases pro-environmental purchase intention
Loss of Fmr1 reorganizes the multi-elemental composition across tissues in Fragile X Syndrome mice
Fragile X Syndrome (FXS) results from a genetic mutation which silences the expression of Fragile X Messenger Ribonucleoprotein (FMRP). FMRP serves various roles regulating cellular protein synthesis...
Could molecular variations be predictive in right and left colon cancer in different gender and age groups?
Background Left-sided colon-cancer (LCC) and right-sided colon cancer (RCC) harbor different clinical entities and different therapy protocols. Our study aim...
Barriers and facilitators to hepatitis C patient engagement: Interview study with general practitioner champions in England
There are people living with a previously diagnosed chronic hepatitis C infection who have been lost to follow up, and people who may have undiagnosed hepatitis C. General Practitioners (GPs) could he...
Heptapharmacological activity of Quercetin-3-O-phosphate against lung cancer pathways
Lung cancer is one of the leading causes of cancer-related deaths globally, with smoking being the primary risk factor, though environmental exposures and genetic mutations also play significant roles...
Transcriptomic meta-analysis identifies dysregulated pathways and potential therapeutic targets in Vestibular Schwannoma
Vestibular schwannoma (VS) is a benign Schwann cell–derived tumor that frequently causes progressive hearing loss and vestibulocochlear dysfunction, substantially impacting quality of life. The molecu...
AI-driven diagnosis of mpox using deep learning models
Mpox lesions can resemble other dermatological conditions, motivating image-based screening, yet published studies remain difficult to compare owing to differences in dataset construction, augmentatio...
Enhancing perovskite solar cells efficiency via dual surface passivation
Effective defect passivation is essential for achieving high performance in perovskite solar cells (PSCs). Dimensional engineering provides a powerful strategy to suppress non-radiative recombination...
Research on the protection and restoration technology of glazed components in ancient architecture
In traditional Chinese architecture, glazed tile components are a significant decorative element that are frequently utilized on walls and roofs. However, glazed tile components typically show variabl...
Physical activity and quality of life in children: Findings from the Health Oriented Pedagogical Project (HOPP)
Purpose The purpose of this study was to examine the associations between a 5-year school-based physical activity (PA) intervention and quality of life (QoL) in children aged 6–12...
Machine learning-based analysis of drug resistance mutations in Mycobacterium tuberculosis
Tuberculosis is a deadly airborne disease caused by Mycobacterium tuberculosis . Drug-resistant tuberculosis presents significant challenges for treatment and c...
Topical sterosomes-based nanocarrier of miconazole for the management of cutaneous candidiasis
Background Miconazole (MN) is widely used to treat superficial fungal infections; however, limited skin penetration and short residence time restrict its therapeutic efficacy. This...
Semi-analytical hierarchical Bayesian inference of nonlinear model structure in stochastic dynamics: Applied to compartmental models of infectious diseases
A Bayesian computational framework for parsimonious inference in stochastic nonlinear dynamical systems is presented. This framework enables the concurrent estimation of system states, time-varying pa...
Real‑world safety evaluation of tranexamic acid: Signal detection from FAERS and VigiAccess databases
Background Tranexamic acid (TXA) is an antifibrinolytic agent commonly used to mitigate blood loss across various medical indications. Despite its widespread use, comprehensive dat...
Preferences for accessing sexual and reproductive health information and services among adolescent girls and young women in higher learning institutions in Tanzania: A qualitative study
Introduction Adolescence is a critical developmental stage characterized by significant physical, emotional, and cognitive changes, including sexual maturation. However, this popul...
Exploring the knowledge, attitudes, and perceptions of young men towards fertility in the UK: A cross-sectional survey
Introduction Across many countries, paternal age at childbirth is rising, increasing exposure to age-related fertility decline. This study evaluated fertility-related knowledge, at...
Topical medium-length PDRN enhances dermal extracellular matrix repair in photodamaged skin via PI3K–Akt/TGF-β–regulated pathways
Chronic ultraviolet (UV) exposure disrupts dermal fibroblast function and extracellular matrix (ECM) homeostasis, driving the structural features of photoaged skin. Polydeoxyribonucleotide (PDRN) has...
Protocol for a Delphi consensus study to identify priority characteristics of integrated care for individuals with severe mental illness and comorbid physical disorders in Europe
Introduction Individuals with severe mental illness (SMI) experience persistent and complex physical health needs that remain insufficiently addressed. While integrated care repres...