PLoS ONE
Articles in this Issue
Seasonality, long-term trends and co-occurrence of sharks in a top predator assemblage
Shark predator assemblages play an important role in the top-down processes that are vital to marine ecosystem functioning. Spatiotemporal partitioning of sharks due to seasonal movements or populatio...
The WellNext Scan: Validity evidence of a new team-based tool to map and support physicians’ well-being in the clinical working context
Occupational well-being is inherent to physicians’ professional performance and is indispensable for a cost-effective, robust healthcare system and excellent patient outcomes. Increasing numbers of ph...
Hyaluronic acid: Function and location in the urothelial barrier for bladder pain syndrome/interstitial cystitis, an in vitro study
Disruption of the glycosaminoglycan (GAG)-layer and urothelial barrier is an important aspect of the pathophysiology of bladder pain syndrome/ interstitial cystitis. Intravesical hyaluronic acid (HA)...
Amoxicillin-induced bacterial gut dysbiosis decreases IL-1β and IL-6 expression but exacerbate lung inflammatory response against Mycobacterium bovis—Bacille Calmette-Guérin (BCG)
Tuberculosis is one of the leading causes of global mortality, and the standard, prolonged, and intensive treatment can affect intestinal homeostasis. This study investigated amoxicillin-induced bacte...
The edge orientation entropy of natural scenes is associated with infant visual preferences and adult aesthetic judgements
Statistical regularities of oriented edges in natural scenes, ‘edge co-occurrence statistics’, are associated with adults’ aesthetic responses, with greater preference for some images when the degree...
Adaptive control and state error prediction of flexible manipulators using radial basis function neural network and dynamic surface control method
This paper introduces a novel control strategy for managing the uncertainties in flexible joint manipulators, incorporating a Radial Basis Function Neural Network (RBFNN) with Adaptive Dynamic Surface...
Temporal distribution shifts of Chum salmon (Oncorhynchus keta) with sea surface temperature changes at their southern limit in the North Pacific
Understanding the responses of marine organisms to environmental changes at their distribution limits is crucial for predicting climate-change associated habitat changes. This study analyzed the effec...
Machine learning-based prediction of distant metastasis risk in invasive ductal carcinoma of the breast
More than 90% of deaths due to breast cancer (BC) are due to metastasis-related complications, with invasive ductal carcinoma (IDC) of the breast being the most common pathologic type of breast cancer...
Evaluation of Moore and grab sampling method for Salmonella Typhi detection in environmental samples in Ghana
Background Typhoid fever causes substantial mortality and morbidity in low and middle-income countries (LMICs) as a result of inadequate water, hygiene, and...
Comparison of two methods of measuring physical activity and its related components among middle age women: Pedometer versus self-report
Introduction Physical activity is essential for health maintenance across various dimensions; however, sedentary behavior remains widespread in numerous societies. Notably, women often exhibit higher...
Multiomics in silico analysis identifies TM4SF4 as a cell surface target in hepatocellular carcinoma
The clinical application of cellular immunotherapy in hepatocellular carcinoma (HCC) is impeded by the lack of a cell surface target frequently expressed in HCC cells and with minimal presence in norm...
Plasma attenuates endothelial injury compared to crystalloids in a ventilated rat pneumosepsis model
Background The dysregulated immune response during sepsis involves endothelial injury, which may be augmented by infusion of clear fluids such as crystalloids. Plasma has been suggested as an alternat...
Transcriptomic adaptation of skeletal muscle in response to MICT and HIIT exercise modalities
Skeletal muscle exhibits remarkable plasticity in response to diverse stimuli, with exercise serving as a potent trigger. Varied exercise modalities, including moderate-intensity continuous training (...
Chemical composition and biological activity of lemongrass volatile oil and n-Hexane extract: GC/MS analysis, in vitro and molecular modelling studies
Lemon grass, formally identified as Cymbopogon citratus, is a plant that belongs to the Poaceae family. The present work aimed to examine the chemical composition by GC/MS analysis and assess the biol...
Differential expression and modulation of EBI2 and 7α,25-OHC synthesizing (CH25H, CYP7B1) and degrading (HSD3B7) enzymes in mouse and human brain vascular cells
The endogenous ligand for the EBI2 receptor, oxysterol 7α,25OHC, crucial for immune responses, is finely regulated by CH25H, CYP7B1 and HSD3B7 enzymes. Lymphoid stromal cells and follicular dendritic...
Co-representation breaks down beyond the dyad in UK adults
Cooperation is so deeply embedded in human psychology that we spontaneously track a partner’s task as well as our own when acting in a pair. This automatic ‘co-representation’ of a partner’s mental re...
Enhancing anesthetic techniques for improving whisker stimulation response in the barrel cortex
This study adopts and validates an anesthetic protocol designed for rat whisker stimulation experiments, achieving significant enhancements in the neural response of the barrel field cortex. By combin...
Crypto-coding technique based on polar code and secret key generated from wireless channel characteristics for wireless communication systems
The crypto-coding technique is essential for modern digital wireless communications systems, allowing data encryption and channel coding to be performed in only one step without requiring additional h...
A comparison of the burden of cancers between 1990 and 2019 in Iran: A national and subnational study
Background Cancer is a rapidly increasing global problem, and one of the leading causes of burden and mortality. This study aims to compare the burden of cancer in Iran between the year 1990 and 2019...
Evaluation of different intramuscular injectable anesthetic combinations in rabbits: Impact on anesthetic depth, physiological parameters, and EEG recordings
Rabbits have a high anesthesia-related mortality rate because of their small size, high metabolic rate and challenging airway management. This study aimed to investigate different combinations of intr...
HLA-class II genes association with multiple sclerosis: An immunogenetic prediction among multiple sclerosis Jordanian patients
Multiple sclerosis (MS) is an inflammatory autoimmune disease affecting the central nervous system (CNS). The pathogenesis of MS is characterized by neuronal axonal degeneration and demyelination. Amo...
Predicting IVF live -birth probability using time-lapse data: Implications of including or excluding age in a day 2 embryo transfer model
The primary objective of this study was to develop predictive models for the likelihood of live births following In Vitro Fertilisation (IVF) treatment, based on a retrospective analysis of time-lapse...
Ecuadorian Holstein-Friesian cattle paternal lineages: Demographic structure, inbreeding evolution, and genetic diversity
Holstein-Friesian cattle are the most important dairy breed worldwide. The main objective was to carry out a detailed pedigree evaluation of the Ecuadorian Holstein-Friesian cattle to investigate the...
Acute and sub-acute toxicity of ethanol extracts of Hagenia abyssinica and Rumex abyssinicus flowers in Swiss albino mice
Background Hagenia abyssinica (Bruce) J.F. Gmel (Family: Rosaceae) and Rumex abyssinicus Jacq (Family: Polygonaceae) are valuable medicinal plants traditionally used in Ethiopia to treat various disea...
Dietary patterns and their associations with the occurrence and severity of early childhood caries among 1–5-year-olds in Iran: A multicenter cluster randomized survey
Aim A health-promoting and tooth-friendly diet can reduce the risk factors associated with early childhood caries (ECC) and promote overall health in children. This study aimed to identify dietary hab...