PLoS ONE
Articles in this Issue
Vocational rehabilitation for people with multiple sclerosis in the national health service of the United Kingdom: A realist evaluation
Background There is limited evidence about how vocational rehabilitation (VR) for people with multiple sclerosis (MS) can be delivered through the United Kingdom’s (UK) National Health Service (NHS) a...
Self-rehabilitation strategy for rural community-dwelling stroke survivors in a lower-middle income country: a modified Delphi study
Background More than half of stroke survivors in lower-middle income countries lack access to stroke rehabilitation services. The promotion of self-rehabilitation could be promisin...
Quantifying variation of non-point source pollution and its impact factors: A study of Nansi Lake Basin
Agricultural non-point source (NPS) pollution directly affects the quality of soil and water, ecological balance and human health, and is a key challenge to achieve sustainable environmental developme...
FAM50A as a novel prognostic marker modulates the proliferation of colorectal cancer cells via CylinA2/CDK2 pathway
Objective Colorectal cancer (CRC) is the third most prevalent malignant tumor type and the second leading cause of cancer-related death. Sequence similarity family 50 member A (FAM50A) plays a vital...
Sudden cardiac death after coronary artery bypass graft surgery and role of antiplatelet therapy
Background While coronary artery bypass grafting (CABG) surgery is effective in reducing the risk of myocardial infarction and subsequent cardiac events by improving myocardial perfusion, the risk of...
L-shaped relationship between dietary niacin intake and hearing loss in United States adults: National health and nutrition examination survey
Hearing loss poses a significant threat to human health, with its prevalence increasing annually. Niacin (vitamin B3) is an essential B vitamin that plays a crucial role in energy metabolism and cellu...
Key factors in supporting adolescents to achieve high self-esteem and a positive body image: A qualitative community-based study
Introduction Body dissatisfaction can be affect adolescents’ mental health, leading to issues with body weight control, low self-esteem, and poor school performance. Methods A total of 24 interviews...
Trustworthy diagnosis of Electrocardiography signals based on out-of-distribution detection
Cardiovascular disease is one of the most dangerous conditions, posing a significant threat to daily health. Electrocardiography (ECG) is crucial for heart health monitoring. It plays a pivotal role i...
Revisiting Pearl’s influenza studies by bootstrapping for forward variable selection with a null factor
In 1919 and 1921 Raymond Pearl published four empirical studies on the Spanish Flu epidemic in which he explored the factors that might explain the explosiveness and destructiveness of the epidemic in...
Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, double-blind, placebo-controlled trial
Aim Niclosamide is an established anthelmintic substance and a promising candidate for treating cancer, viral infections, and other diseases. However, its solubility in aqueous med...
Consumer attitudes and perceptions on consumption of edible insects among communities in western Kenya
Edible insects are a highly sustainable and nutritional food source despite their low consumption in many communities. This study evaluated consumer attitudes and perceptions on consumption of edible...
Sex and pressure effects of foam rolling on acute range of motion in the hamstring muscles
This study investigated the effects of pressure levels and sex on acute range of motion (ROM) changes during foam rolling (FR) using a soccer ball. Twenty collegiate athletes (10 males, 10 females) pe...
The link between impact-induced tensile strain and dendritic spine morphology in porcine brain tissue
Brain tissue as a material presents unique properties with a multitude of cell types and densities, varying degrees of axonal fiber diameters and blood vessels. These neural components are contained w...
Estimating the dietary and health impact of implementing mandatory front-of-package nutrient disclosures in the US: A policy scenario modeling analysis
Background Recognized as a cost-effective policy to promote healthier diets, mandatory front-of-package labeling (FOPL) identifying foods high in sodium, sugar, and saturated fat h...
The alteration of uterine microbiota participated in the activation of the decidual inflammatory response in early spontaneous abortion
Background Early spontaneous abortion (ESA) is one of the most common clinically recognized pregnancy complications. While multiple factors such as embryo abnormalities and maternal conditions may con...
Vertical distribution of methanotrophic archaea in an iron-rich groundwater discharge zone
Anaerobic oxidation of methane coupled to iron reduction (Fe-AOM) is a crucial process for methane removal in terrestrial environments. However, the occurrence of Fe-AOM in natural environments is rar...
Enhancing communication in healthcare: Supports for interactions between adults with hearing loss and healthcare providers
Background Communication between a healthcare provider and an adult with hearing loss can be challenging and potentially contribute to health outcomes. To overcome this challenge, researchers have cal...
Optimizing Bi-LSTM networks for improved lung cancer detection accuracy
Lung cancer remains a leading cause of cancer-related deaths worldwide, with low survival rates often attributed to late-stage diagnosis. To address this critical health challenge, researchers have de...
Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR
Therapeutic targeting of the adenosine deaminase ADAR has great potential in cancer and other indications; however, it remains unclear what approach can enable effective and selective therapeutic inhi...
Evaluation of stroke sequelae and rehabilitation effect on brain tumor by neuroimaging technique: A comparative study
This study aims at the limitations of traditional methods in the evaluation of stroke sequelae and rehabilitation effect monitoring, especially for the accurate identification and tracking of brain in...
Pathways to sustainability: Higher education and green productivity
The research conducted theoretical analysis and empirical testing on the relationship between higher education and regional green productivity based on panel data from 30 Chinese provinces from 2003 t...
Mutational alterations in the QRDR regions associated with fluoroquinolone resistance in Pseudomonas aeruginosa of clinical origin from Savar, Dhaka
Bacterial DNA gyrase and topoisomerase IV are the major targets of quinolone antibiotic, and mutational alterations in quinolone resistance determining regions (QRDR) serve as major mechanism of resis...
Time-sensitive effects of quercetin on rat basophilic leukemia (RBL-2H3) cell responsiveness and intracellular signaling
Quercetin is known for its ability to inhibit mast cell degranulation and reduce the release of inflammatory mediators. However, it has also been reported to sensitize mast cells, potentially leading...
Victimization status among persons with disabilities and its predictors: Evidence from Bangladesh National Survey on Persons with Disabilities
Background Persons with disabilities often face various forms of victimization, yet there is limited research exploring this phenomenon in Bangladesh. This study aims to investigat...
Exploring cotton plant compounds for novel treatments against brain-eating Naegleria fowleri: An In-silico approach
To find potential inhibitors of Naegleria fowleri S-adenosyl-L-homocysteine hydrolase (NfSAHH), a brain-eating parasite, structure-based drug design was adopted. N. fowlerica causes primary amebic men...