PLoS ONE
Articles in this Issue
Gynecologic health of women with multiple sclerosis: An overview on the current status and findings of Pap tests in a low-income setting
Background Women with MS (wwMS), particularly ones in low-income settings, and exposed to disease-modifying therapy (DMT), could have specific gynecological health-related issues. Aim To assist p...
Application of observational research methods to real-world studies for rare disease drugs: A scoping review protocol
The primary objective is to identify which observational research methods have been used in the last 5 years in rare disease drug evaluation and how they are applied to generate adequate evidence rega...
In silico design of Ebola virus Glycoprotein antigenic peptides as vaccine candidates
Ebola virus (EBOV) is a filovirus that causes severe hemorrhagic fever and has a fatality rate between 50 and 90%. The vaccines were developed against the Ebola Zaire species; therefore, it is necessa...
Detection of central and obstructive sleep apneas in mice: A new surgical and recording protocol
Sleep apnea is a common respiratory disorder in humans and consists of recurrent episodes of cessation of breathing or decrease in airflow during sleep. Sleep apnea can be classified as central or obs...
Analysis of chronic disease comorbidity patterns in middle-aged and elderly smokers in China: The China Health and Retirement Longitudinal Study
Background China has the largest tobacco consumer population in the world, and with the increasing severity of aging, the health issues caused by smoking continue to draw attention. This study aims to...
Positive association between stress hyperglycemia ratio and ICU mortality in patients with pulmonary embolism: A retrospective study
Background Measurement of the Stress Hyperglycemia Ratio (SHR) aims to reduce the influence of prolonged chronic glycemic variables on stress hyperglycemia levels, which are associated with clinical o...
Substance use among young people in the West Arsi Zone, Ethiopia: A cross-sectional study
Introduction Substance use is a pressing public health concern in young Ethiopians, impacting their physical, psychosocial, and emotional well-being and productivity. However, there is a limited under...
Predictive value of uric acid to albumin ratio for carotid atherosclerosis in type 2 diabetes mellitus: A retrospective study
Background This study aims to evaluate the correlation between the uric acid (UA) to albumin (ALB) ratio (UAR) and carotid atherosclerosis (CAS) in patients with type 2 diabetes mellitus (T2DM), as we...
Integrated analysis and single-cell sequencing of mitochondrial metabolism related gene molecular subtype and diagnostic model in ulcerative colitis
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that seriously affects the life expectancy of patients. Although increasingly sophisticated combinations of drugs can alleviate symptoms...
A randomized controlled trial of a family-based HIV/STI prevention program for Black girls and male caregivers in Chicago: IMAGE study protocol paper
Black girls are disproportionately impacted by HIV and STIs in the United States. Black male caregivers are underutilized in family-based HIV/STI prevention programming and offer a novel opportunity t...
The impact of self-isolation on psychological wellbeing in adults and how to reduce it: A systematic review
Objective To synthesise evidence on the impact of self-isolation at home on the psychological and emotional wellbeing of adults in the general population during the COVID-19 pandemic. Methods This s...
Epigenome-wide methylation analysis shows phosphonoethylamine alleviates aberrant DNA methylation in NASH caused by Pcyt2 deficiency
Background Aberrant DNA methylation can lead to the onset of pathological phenotypes and is increasingly being implicated in age-related metabolic diseases. In our preceding study we show that the het...
Observation of upstream particle movement without the involvement of the marangoni effect
Upstream Contamination is a counter-intuitive phenomena of fluid dynamics, where particles can go against the liquid stream and climb, higher containers. Previous studies have attributed the movement...
Effect of weathered on the pore characteristics of different rocks in coal-bearing strata
This study aims to explore how weathered controls the microscopic pore development of rocks. Siltstones to coarse sandstones were selected from the main rocks of the Jurassic strata of the northern Or...
Newcomb-Benford number law and ecological processes
The Newcomb-Benford number law has found applications in the natural and social sciences for decades, with limited ecological attention. The aim of this communication is to highlight a statistical cor...
Translators as mediators to mend the psychological gap between source text and target text: A corpus-based study on the Chinese English translation of modal verbs in the Chinese Report on the Work of the Government (2000–2022)
This study examines the role of translators as mediators in bridging the psychological gap between source text (ST) and target text (TT) through a corpus-based analysis of Chinese English translation...
Development and comparison of single FLT3-inhibitors to dual FLT3/TAF1-inhibitors as an anti-leukemic approach
Acute myeloid leukemia (AML) is characterized by several recurrent mutations that affect disease biology and phenotype, response to therapy and risk of subsequent relapse. Though tyrosine kinase inhib...
Functional profiling of synthetic camel milk-derived peptides with implication in glucose transport and diabetes
We previously identified protein hydrolysates from camel milk (CM) targeting dipeptidyl peptidase IV (DPP-IV) and insulin receptor (IR) activity. In this study, we synthesized nine peptides (P1 to P9)...
Examining access to and trust in sources of COVID-19 information among CALD Asian communities in New Zealand
During the COVID-19 pandemic, effective crisis communication has been crucial yet challenging, especially for culturally and linguistically diverse (CALD) communities. This study explored how CALD Asi...
Deep-sea mining and its risks for social-ecological systems: Insights from simulation-based analyses
The pros and cons of deep-sea mining (DSM) is currently hotly debated. Here, we assess the environmental, economic, and social risks of DSM by comparing scenarios with and without DSM involvement. The...
Morphological and environmental varieties of the Cambrian stromatolites in Western Henan, North China Craton
Morphological varieties of Cambrian stromatolites in western Henan, North China Craton were essentially related to palaeoenvironmental parameter changes of the marine-floor. Small plexiform, hemispher...
Information usefulness of public disclosure in Taiwan: Does it vary across specific diseases/conditions and contexts?
Objectives This study discusses issues regarding tailored information for report cards, including what kinds of information patients with different diseases need and how the necessary information chan...
A comparison of the knowledge of hormonal contraception between women living in urban and rural areas of Poland
The Contraception Policy Atlas and its latest 2024 study shows that the availability of contraception in Poland is a meagre 33.5%, the lowest of all European countries. The aim of the research, theref...
The NADC30-like PRRSV activates the integrin αV subunit to facilitate its entry into Marc-145 cells
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious virus that poses a significant threat to the global pig farming industry, resulting in substantial economic losses. H...
Work attendance anxiety, precarious work schedules, and job satisfaction of essential retail workers during the early COVID-19 pandemic
Building upon the Job Demands-Resources model, this study examines the relationships among precarious work schedules, work attendance anxiety, and employer support during the early COVID-19 pandemic....