PLoS ONE
Articles in this Issue
Comparative effect of high intensity interval training and moderate intensity continuous training on metabolic improvements and regulation of Cidea and Cidec in obese C57BL/6 mice
Obesity is a chronic disease associated with increased risk of cardiovascular disease, diabetes, metabolic dysfunction associated steatotic liver disease and certain cancers. High intensity interval t...
No evidence of reduced capacity during highly demanding cognitive tasks in healthy older adults at electroencephalographic risk of cognitive impairment
Healthy older adults with excessive theta absolute power (AP) are considered at electroencephalographic risk of developing cognitive impairment 7 to 10 years later. Although this population may exhibi...
Barriers and opportunities for community engagement in UAV-based dengue management in rural Malaysia
Dengue fever remains a significant public health issue in Malaysia, particularly in rural areas where unique challenges such as dispersed populations, limited infrastructure, and distinct socio-cultur...
A survey on the use of continuous positive airway pressure in newborn care in Kenya in 2017–2018
Background Globally, complications of preterm birth are the leading cause of under-5-mortality. Respiratory distress syndrome (RDS) is a common and life-threatening complication among preterm infants....
This condition impacts every aspect of my life: A survey to understand the experience of living with developmental prosopagnosia
This mixed methods study examined the real-world experiences of living with developmental prosopagnosia (face blindness), a lifelong neurodevelopmental condition that severely affects the ability to r...
Exosomes from human umbilical cord mesenchymal stem cells promote the growth of human hair dermal papilla cells
Human hair dermal papilla cells (HHDPCs) play a significant role in hair growth. This study found that human umbilical cord mesenchymal stem cell-derived exosomes (UC-MSC-Es) effectively enhanced cell...
Topical fluoride hesitancy and opposition are significantly and positively associated: A cross-sectional study
The goal of this study was to evaluate the associations between topical fluoride hesitancy and opposition to determine if hesitancy is a potential precursor to opposition. We administered an 85-item s...
Effects of preoperative stress, depression, social support, and self-compassion on resilience in surgical patients
Background Limited research has been conducted on the psychological factors experienced by patients before surgery. This study examined the effects of preoperative stress, depression, social support,...
PrEP knowledge, attitudes, and perceived barriers to access among American Indian/Alaska Native people in the US: Results from an online survey
Introduction Compared to non-Indigenous communities, American Indian/Alaska Native (AI/AN) people are inequitably impacted by HIV, yet few data are available on barriers to pre-exposure prophylaxis (P...
Policies for healthy ageing in response to climate change: Protocol of a systematic review
Climate change is a global phenomenon affecting every segment of the population. Yet, older adults are more vulnerable to climate change events (e.g., floods, heatwaves, landslides) owing to their fun...
School-based interventions to prevent anxiety and depression in children and adolescents in low- and middle-income countries: A systematic review
Background Anxiety and depression are on the rise among children and adolescents globally. Low- and middle-income countries (LMICs) face heightened vulnerability due to limited resources, restricted a...
The association between weight-adjusted waist index and respiratory symptoms in U.S adults: A national cross-sectional study
Objective This study aimed to evaluate the relationship between the weight-adjusted waist index (WWI) and respiratory symptoms, including cough, wheezing, and dyspnea, as well as the related respirato...
Impact of surgery on rehabilitation care and quality of life perceived by patient with post-stroke upper limb spasticity: Study protocol for a randomized controlled trial
Background Stroke is the principal cause of permanent disability in adult age, and many patients require lifelong medical treatment and care from others for their daily activities. It has enormous rep...
Determining whether weight status mediates the association between number of cigarettes smoked per day and all-cause mortality among US adults who smoke cigarettes
Introduction While there is evidence demonstrating the association between cigarette smoking and weight status, and mortality and weight status, it has not been examined whether weight status is a med...
PTPN21 inhibits cell apoptosis of acute lymphoblastic leukemia induced by chemotherapeutic agents via GADD45A and JNK signaling pathway
Acute lymphoblastic leukemia (ALL), a hematologic malignancy characterized by the uncontrolled proliferation of immature lymphocytes, often results in unfavorable long-term survival prospects for pati...
Analyzing and predicting global happiness index via integrated multilayer clustering and machine learning models
This study addresses the research objective of predicting global happiness and identifying its key drivers. We propose a novel predictive framework that integrates unsupervised and supervised machine...
Risk factors of phlebitis in patients admitted to the intensive care unit vary according to the duration of catheter dwelling: A post-hoc analysis of the AMOR-VENUS study
Aim This study investigated the risk factors of peripheral intravenous catheter (PIVC)-related phlebitis in critically ill patients according to the duration of catheter dwelling. Methods This was a...
Correction: On people’s perceptions of climate change and its impacts in a hotspot of global warming
Trends in prevalence and treatment of antepartum and postpartum depression in the United States: Data from the national health and nutrition examination survey (NHANES) 2007 to 2018
Objectives (1) To assess the prevalence of depression and treatment rates in antepartum and postpartum women compared to a control group of reproductive-age women over a 12-year period, and (2) To det...
Increasing hospital administrative efficiency via optimized office automation systems: A PDCA cycle approach
Background Increasing hospital administrative efficiency is crucial with regard to efforts to manage competitive pressures in healthcare. Despite extensive research on healthcare optimization, the rol...
Comparison of mid-term outcomes between unilateral biportal endoscopic and minimally invasive transforaminal lumbar interbody fusion in the treatment of single-level lumbar degenerative disease
Objective To compare the mid-term clinical and radiological outcomes between unilateral biportal endoscopic transforaminal lumbar interbody fusion (ULIF) and minimally invasive transforaminal lumbar i...
Pre-service teachers’ empathy and attitudes toward inclusive education—The chain mediating role of teaching motivation and inclusive education efficacy
Recently, inclusive education has become the direction of special education development. Inclusive education requires that teachers’ educational philosophies and approaches meet the needs of all stude...
Biomechanical performance of a novel zero-profile interbody cage: A cadaveric study
Zero-profile cage (ZPC) products have been widely used in anterior cervical decompression and fusion (ACDF) surgery. To develop a ZPC that meets the biomechanical requirements of the Chinese populatio...
A minimalist computational model of slice hippocampal circuitry based on Neuronify for teaching neuroscience
The hippocampal formation is vital for processing memory, learning, and spatial navigation. Existing methods are obsolete to address new emerging questions as our understanding of hippocampal circuits...
Investigating parental factors that lead to adolescent Internet Gaming Addiction (IGA)
Internet gaming addiction (IGA) has become a common phenomenon that affects adolescents, due to its possible negative effects on physical and mental health issues. However, very few studies have parti...