PLoS ONE
Articles in this Issue
Well-being inequities in eleven rural Georgia communities: A latent profile analysis
Personal well-being is a broad term that encompasses life domains that are not strictly health related, including social, emotional, financial, and environmental factors. Well-being is highly correlat...
A state observer-based robust control method for perturbation-containing nonlinear discrete interconnected Systems
In this study, the problem of the robust control of interconnected systems was investigated. A controller design method based on a state observer is proposed for nonlinear discrete interconnected syst...
HFKG-RFE: An algorithm for heterogeneous federated knowledge graph
Federated learning ensures that data can be trained globally across clients without leaving the local environment, making it suitable for fields involving privacy data such as healthcare and finance....
Differential immunogenicity in people living with HIV with varying CD4 levels after bivalent mRNA COVID-19 booster vaccination
People living with HIV (PLWH) exhibit heterogeneous immune responses, influenced by varying degrees of immune deficiency and viral suppression. The efficacy of COVID-19 vaccines in this population rem...
Managing obstetric bleeding in Wales: A qualitative evaluation of the OBS Cymru care bundle using Normalisation Process Theory
Background Post-partum haemorrhage (PPH) is one of the leading causes of maternal mortality and morbidity worldwide. The Obstetric Bleeding Strategy (OBS) care bundle for PPH management was adopted in...
DERL3 facilitates the progression of clear cell renal cell carcinoma by promoting epithelial-mesenchymal transition via regulation of the TGFB1 pathway
Background Clear cell renal cell carcinoma (ccRCC) is a highly prevalent malignancy within the urinary system. The intrinsic heterogeneity and resistance to conventional chemotherapy and radiotherapy...
Preference reversals in ethicality judgments of medical treatments
In medical ethics, there is often a tradeoff between maximizing treatment efficacy and alleviating patient suffering. We adapt methods from consumer behavior research to examine whether ethicality jud...
Understanding the effect of human capital and decent work for migrants’ integration using PLS-SEM
This study investigates the impact of human capital on the integration of Venezuelan migrants in Peru, considering decent work as a crucial mediator. The research involved a sample of 1,193 Venezuelan...
Moderate static magnetic fields prevent estrogen deficiency-induced bone loss: Evidence from ovariectomized mouse model and small sample size randomized controlled clinical trial
Background Postmenopausal osteoporosis (PMOP) is the most common type of osteoporosis. Numerous studies have shown that static magnetic fields (SMFs) can inhibit bone loss by regul...
Risk of post-acute symptoms among adults: A comparison study of severe COVID-19, pneumonia, and influenza
Background A retrospective cohort study was undertaken to assess the relationship between initial disease severity of COVID-19 and the risk of post-acute symptoms. The COVID-19 cohort was compared aga...
Mobile Phone Network Data in the COVID-19 era: A systematic review of applications, socioeconomic factors affecting compliance to non-pharmaceutical interventions, privacy implications, and post-pandemic economic recovery strategies
Background The use of traditional mobility datasets, such as travel surveys and census data, has significantly impacted various disciplines, including transportation, urban sensing, criminology, and h...
Is neck and shoulder posture, muscle activity and discomfort influenced by tablet inclination in young adults with and without neck pain?
This study aimed to investigate the effect of tablet inclination on neck and shoulder posture, muscle activity, and discomfort in young adults with and without neck pain during a prolonged writing tas...
A practical approach for colorectal cancer diagnosis based on machine learning
In this paper, we present the results of applying machine learning models to build a Colorectal Cancer Diagnosis system. The methodology encompasses six key steps: collecting raw data from Electronic...
Strengthening the role of community pharmacy in HPV vaccination roll-out in Serbia at national and local levels: A pharmacy-based education approach
Cervical cancer is a significant public health concern in Serbia, with high morbidity and mortality rates (27 and 14.2 per 100,000 women, respectively in 2020). The primary cause of cervical cancer is...
Reputation shortcoming in academic publishing
Editors of scientific journals make central decisions in the publication process. Information peripheral to the content of a manuscript such as the editor’s professional circle and authors’ publishing...
Implementation of a smoking cessation intervention for people with severe mental illness in ambulatory mental healthcare (KISMET): A process evaluation
Background Recently, a cluster-randomised controlled trial was conducted within Dutch ambulatory mental healthcare to assess the effectiveness of a one-year smoking cessation intervention consisting o...
Identification of key extracellular proteins as the potential biomarkers in thyroid eye disease
Background Thyroid eye disease (TED) is one of the most common autoimmune orbital diseases in adults. The early diagnosis and effective treatment of TED is a worldwide problem. Extracellular proteins...
Anxiety and depression during pregnancy: Differential impact in cases complicated by preeclampsia and preterm premature rupture of membranes
Background Maternal mental health is crucial for the well-being of both the mother and the fetus. Obstetric complications have been linked to anxiety and depression during pregnancy. Among them, preec...
Prediction of stress-strain behavior of rock materials under biaxial compression using a deep learning approach
Deep learning has significantly advanced in predicting stress-strain curves. However, due to the complex mechanical properties of rock materials, existing deep learning methods have the problem of ins...
A qualitative process evaluation of a nasal spray intervention to prevent respiratory tract infections
Nasal sprays could be used to prevent and manage respiratory tract infections (RTIs). As part of a randomized controlled trial (ISRCTN17936080), participants received one of two nasal sprays (gel-base...
Evidence for an efferent-based prediction contributing to implicit motor adaptation
Models of sensorimotor adaptation have proposed that implicit adaptation is driven by error signals created by discrepancies between various sensory information sources. While proprioception has been...
The incremental value of tuberculosis detecting African giant pouched rats over Smear microscopy and Xpert MTB/RIF for Tanzanian TB detection
Background Prior studies that used Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO)-trained African giant pouched rats reported an annual average of 40% increase in sputum-smear-positive t...
Navigating the biopsychosocial landscape: A systematic review on the association between social support and chronic pain
The biopsychosocial model is widely used to explain chronic pain conditions. Yet, the role of social aspects including social support is not clear. Literature on social support and chronic pain is sti...
Promoting sleep and mental well-being in children: Protocol for a naturalistic pilot in-app study among users of the Aumio app
Sleep problems are widespread among children and can have a negative impact on their development, everyday functioning and pose an additional burden on the parents. While there are numerous apps desig...
Evaluation of the utility of cardiac biomarkers for risk stratification in patients with lower extremity artery disease: A retrospective study
Critical limb threatening ischemia (CLTI) is associated with a one-year mortality rate of up to 25% making prompt diagnosis essentially. This study aims to investigate if cardiac biomarkers may serve...