PLoS ONE
Articles in this Issue
A mechanism of global gene expression regulation is disrupted by multiple disease states and drug treatments
Conventional expression studies quantify messenger RNA (mRNA) transcript levels gene-by-gene. We recently showed that protein expression is modulated at a global scale by amino acid availability, sugg...
Spatial distribution characteristics and accessibility analysis in the Weibei Imperial Mausoleum Protection Zone under the hierarchical clustering algorithm
This study mainly aims to investigate the spatial distribution characteristics and accessibility of the Weibei Imperial Mausoleum Protection Zone, and gain a deeper understanding of cultural heritage...
Human and rat ex vivo sweat glands for the observation of acetylcholine induced intracellular calcium signalling
Sweating is imperative for thermoregulatory function in humans. However, many individuals find it undesirable due to its associated malodorous nature. Despite these concerns, aluminium salts remain am...
Whole genome sequencing and molecular detection of potato virus X in Bangladesh
Potato Virus X (PVX) is a significant viral pathogen affecting potato (Solanum tuberosum) crops globally, yet its molecular characterization in Bangladesh remains limited. This study presents the firs...
Immature Citrus unshiu fruit extracts inhibit adipogenesis in 3T3-L1 adipocytes via AMPK and MAPK signaling pathways
In Korea, immature citrus fruits have been extensively explored for their potential utility as functional bio-health materials owing to their various bioactive properties. However, the specific mechan...
Climatic factors driving influenza transmission in Sahelian area: A twelve-year retrospective study in Niger (2010–2021)
The relationship between influenza transmission and climate has many public health implications, particularly on the occurrence of epidemics and disease severity. Environmental factors such as tempera...
MADNet: Marine Animal Detection Network using the YOLO platform
It is necessary to overcome the real-life challenges encountered in detecting marine animals in underwater bodies through computer vision for monitoring their populations and biological data. At the s...
Damping factor in magnetorheological shear stiffening gel: Fabrication and formulation of a fractional constitutive model
A variety of magnetorheological shear stiffening gels (MRSSGs) were synthesised by incorporating varying amounts of carbonyl iron powder (CIP) into a shear stiffening gel (SSG) matrix. The dynamic dam...
Identifying primary-care features associated with complex mental health difficulties
Aim The coded prevalence of complex mental health difficulties in electronic health records, such as personality disorder and dysthymia,is much lower than expected from population surveys. We aimed to...
The effect of social participation on depressive symptoms in older women adults in China: A tracking survey database
Background Under the context of active aging, older women face prominent mental health risks due to their dual vulnerability stemming from biological characteristics and social roles. Given the existi...
The effect of supply chain risks management practices on operational performance of pharmaceutical manufacturing companies in Addis Ababa, Ethiopia: Analytical cross-sectional study
Background The efficient movement of pharmaceuticals through various stakeholders to reach customers in the appropriate quantity and at the right time is achieved through supply chain management. Howe...
Retraction: Structure-based virtual screening of Trachyspermum ammi metabolites targeting acetylcholinesterase for Alzheimer’s disease treatment
Why men are the minority: The perceptions of young men in UK post-primary education about studying psychology at university
Psychology is categorised as a science by most higher education authorities internationally. As with many science, mathematics and engineering fields, women are underrepresented in psychology at senio...
Small-scale protocols to characterize mitochondrial Complex V activity and assembly in peripheral blood mononuclear cells
Complex V of the mitochondrial oxidative phosphorylation system is an ATP synthase that plays a pivotal role in the cell’s energy transduction. Mutations in genes encoding the multiple protein subunit...
Dual-variable control load-sensing system for multi-way valves in hilly and mountainous tractors
To tackle the challenges of severe pressure loss, mismatched flow supply and demand, and high flow demands at pump outlets commonly seen in multi-way valves of hilly and mountainous tractors, a load-i...
Genetic diversity and population structure of soybean (Glycine max (L.) Merril) germplasm
Soybean ( Glycine max (L.) Merril) is a significant legume crop for oil and protein. However, its yield in Africa is less than half the global average resulting...
LncRNA NEAT1 protects uremic toxin-induced intestinal epithelial barrier injury by regulating miR-122-5p/Occludin axis
Background Long non-coding RNA(LncRNA) has been reported to be associated with intestinal barrier damage. The aim of this study was to explore the mechanism of lncRNA Nuclear enriched abundant transcr...
The effect of lidocaine against sepsis-induced acute lung injury in a mouse model through the JAK2/STAT3 pathway
Objective This study aimed to investigate the effects of lidocaine on sepsis-induced acute lung injury and its underlying mechanisms. Methods Thirty C57BL/6 mice were divided into three groups: SHAM...
Diversity in trap color and height increases species richness of bark and woodboring beetles detected in multiple funnel traps
Early detection of non-native, potentially invasive bark beetles and woodboring beetles (BBWB) (Coleoptera: Buprestidae, Cerambycidae, Disteniidae; Curculionidae: Scolytinae) inadvertently introduced...
Is laccase from medicinal mushroom Cerrena unicolor cytotoxic to colon cancer cell line CT-26?
Introduction and objective Colorectal cancer takes an increasing toll every year. Despite the dynamic development of pharmacology, there is still no drug that would be strong enough to cause apoptosis...
Cost savings of outpatient versus inpatient hip and knee arthroplasty in Ontario, Canada
Introduction Hip and knee replacement surgery is one of the most commonly performed elective procedures, accounting for significant healthcare costs and resource utilization. In recent years, the prop...
Prevalence of Post-intensive care syndrome among intensive care unit-survivors and its association with intensive care unit length of stay: Systematic review and meta-analysis
Background Post-intensive Care Syndrome (PICS) is defined as various physical, psychological, and cognitive, impairments that can arise during an ICU stay, continue after leaving the ICU, or even pers...
ESG and corporate performance: The moderating role of government subsidies and mediating effect of analyst coverage in Chinese A-share listed companies
In recent years, the heightened emphasis on sustainable and high-quality economic development has garnered substantial investor interest in corporate ESG performance, significantly influencing the lon...
Prevalence and risk factors of burnout among employees at COVID-19 vaccination centers: A cross-sectional study
Background Health care workers working in Covid-19 vacciantion centers due to their exponential demand experience burnout and stress. Burnout, a psychological syndrome is characterized by emotional ex...
Study on forecasting method of power engineering cost based on BIM and DynGCN
In view of the shortcomings of power engineering cost in precision and dynamic in big data environments, this paper proposes building information modelling (BIM) and spatiotemporal modelling-based dyn...