PLoS ONE
Articles in this Issue
Integrating genomics and transcriptomics reveals candidate genes affecting loin muscle area in Huaxi cattle
Loin muscle area (LMA) is an indicator of carcass composition and is related to weight gain, animal musculature and meat quality traits. Therefore, integrating multi-omics data to reveal candidate gen...
scRNA-seq and scATAC-seq analyses highlight the role of TNF signaling pathway in chronic obstructive pulmonary disease model mice
Chronic obstructive pulmonary disease (COPD) is a prevalent and progressive form of respiratory disease in which patients exhibit persistent respiratory damage affecting the alveoli and/or airway due...
Long-term continuous no-till corn-soybean systems: Examining soil carbon sequestration and nitrogen accumulation across various pools
Tillage practices influence the soil’s capacity as either a sink or source of carbon (C) within agroecosystems. The objective of the study was to assess the effects of no-till (NT) management over 0,...
Enhancing operational efficiency through overall equipment efficiency optimization and Kaizen initiatives
This case study aims to investigate the causes of low efficiency in a carton production line by calculating Overall Equipment Effectiveness (OEE). A typical carton factory has been chosen for this stu...
Burnout and risk factors among anesthesia residents and fellows in a conflict-affected context: A national cross-sectional survey
Background Burnout is an occupational hazard caused by chronic exposure to excessive work-related stress, negatively impacting both clinicians’ well-being and patient safety. Anesthesiology is particu...
Parental involvement in school-based mental health interventions for young people in low-resource settings: A qualitative study from Zimbabwe and Ghana
Background Young people in low-resource settings are disproportionately affected by mental health problems, yet access to formal mental healthcare remains limited. However, schools in these regions ha...
Contributing to evidence-based veterinary medicine: A qualitative study of veterinary professionals’ views and experiences of client-owned companion animal research
Research on the outcomes of veterinary treatments in dogs, cats and horses has important benefits for these animals and their owners. However, this information is not always available, and the evidenc...
Prevalence and associated factors of suicidal behavior among adolescents in Bahir Dar City, Northwest Ethiopia
Background Suicide is a significant public health issue worldwide and the third leading cause of death among 15–19-year-olds. In Ethiopia, while suicidal behaviors among adolescents have a considerabl...
Scene-dependent sound event detection based on multitask learning with deformable large kernel attention convolution
Sound event detection (SED) and acoustic scene classification (ASC) are closely related tasks in environmental sound analysis. Given the interrelationship between sound events and scenes, some previou...
The effect of location in mining or borderland areas on HIV incidence among people who use drugs attending a harm reduction programme in Myanmar, 2014–2021: A retrospective cohort study
Background High HIV prevalence has been documented among people who inject drugs in Myanmar particularly in mining and borderland areas. We estimated incidence of HIV among people...
Determinants of tea planters’ purchasing behavior of planting insurance: SEM analysis
This study explores the influence of government support and risk cognition on tea planters’ purchasing behavior regarding planting insurance, with a particular emphasis on the mediating roles of perce...
Effects of perspective-taking training based on relational frame theory for cognitive empathy and emotional empathy: Differences in perspective-taking according to various theoretical approaches
Perspective-taking has garnered considerable attention across various psychological domains and is often conceptualized as cognitive empathy within the organizational model of empathy. Relational fram...
A protocol for high-dose quadrivalent influenza vaccine effectiveness in the community and long-term care facilities using electronic health records
Since the 2022–2023 season in Portugal, a high-dose quadrivalent influenza vaccine is freely available for individuals living in long-term care facilities (LTCF). In 2024–2025, vaccination was extende...
Study on measurement and prediction of agricultural product supply chain resilience based on improved EW-TOPSIS and GM (1,1)-Markov models under public emergencies
The COVID-19 pandemic, African Swine Fever, and other major public health emergencies have affected the agricultural product supply chain in recent years. It appeared in various chain breakdown and bl...
Spatial layout characteristics of Northern Wei Luoyang: A spatial humanities analysis of the “Record of the Monasteries of Luoyang”
This paper explores the urban spatial structure and social stratification of Northern Wei Dynasty Luoyang City, based on Record of the Monasteries of Luoyang. Adopting a spatial humanities approach, t...
An analysis of adolescent leisure activity structure based on subjective well-being: Focusing on social network analysis
This study examines how adolescent leisure activity networks relate to subjective well-being (SWB) using Statistics Korea’s 2019 Time Use Survey. The analysis includes 241 high-SWB and 241 low-SWB ado...
Study on axial compressive behavior and mesoscopic structural evolution of FRP confined coal gangue concrete
To address the environmental hazards caused by coal gangue waste, coal gangue concrete (CGC) has been proposed as a solution. However, due to its porosity and low strength, CGC faces numerous challeng...
TempO-seq and RNA-seq gene expression levels are highly correlated for most genes: A comparison using 39 human cell lines
Recent advances in transcriptomics technologies allow for whole transcriptome gene expression profiling using targeted sequencing techniques, which is becoming increasingly popular due to logistical e...
Direct evidence for processing Isatis tinctoria L., a non-nutritional plant, 32–34,000 years ago
Recovering evidence for the intentional use of plants in the Palaeolithic is challenging due to their perishable nature as, unlike chipped stone or bone artefacts, plant remains are rarely preserved....
Scoping review of methods of monitoring acute changes in lower body neuromuscular function via force plates
Force plates are amongst the most utilised technological apparatus for monitoring acute changes in neuromuscular function in sports. Practitioners apply monitoring strategies to manage neuromuscular f...
MiR-129-5p alleviates depression and anxiety by increasing astrocyte ATP production partly through targeting deubiquitinase Mysm1
Major depressive disorder (MDD) is a major global mental concern that severely affects quality of life, yet current pharmacological treatments remain limited in their effectiveness. Long-term chronic...
Seasonality of medically attended norovirus gastroenteritis and its association with climatic factors within an US integrated healthcare system, 2016–2019
Background While acute gastroenteritis (AGE) occurs year-round, norovirus has a winter seasonality in the United States. Objective We analyzed norovirus seasonality within a US integrated healthcare...
Generative artificial intelligence in secondary education: Applications and effects on students’ innovation skills and digital literacy
As generative artificial intelligence (AI) rapidly transforms educational landscapes, understanding its impact on students’ core competencies has become increasingly critical for educators and policym...
LBA-YOLO: A novel lightweight approach for detecting micro-cracks in building structures
Developing an efficient and accurate algorithm for detecting building cracks, especially micro-cracks, is essential for ensuring structural integrity and safety. The identification and precise localiz...
Evolving demographics of eligible patient population can impact enrollment of a biomarker clinical study
In a prospective clinical study to better understand how biological markers can improve diagnosis of and prognosis for asthmatic and atopic conditions, we contacted over 3500 eligible patients and obs...