PLoS ONE
Articles in this Issue
Comprehensive assessment of the acute lethal, risk level, and sub-lethal effects of four insecticides on Trichogramma ostriniae
Trichogramma ostriniae is one of the most successfully used natural enemies in the integrated management of agroforestry pests. However, the extensive use of insecticides poses a significant threat to...
SEIQRS model analysis and optimal control with two delays
This paper addresses the limitations of assuming a bilinear infection rate in computer virus propagation models by proposing a more realistic nonlinear dual-delay SEIQRS model. The key focus of the re...
Changes in working and health conditions in different sectors between 2010 and 2019 in a representative sample of French workers
Background Studies on evolution of working conditions and workers’ health in developed countries show conflicting results, and often fail to identify evolutions by occupational sector. This study aime...
Probing the binding hypothesis of Smad3 modulators by molecular dynamic simulations for Atherosclerosis Cardiovascular Disease (ASCVD)
Transforming Growth Factor β (TGFβ) pathway has been recognized as one of the major processes involved in fibrotic diseases including the Atherosclerosis Cardiovascular Disease (ASCVD). Many drugs hav...
Immune-mediated enterocolitis is associated with immune checkpoint inhibitors: A pharmacovigilance study from the FDA Adverse Event Reporting System (FAERS) database
Purpose Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by demonstrating significant efficacy across multiple malignancies. However, by interfering with immune regulatory path...
Biased perceptions of public opinion don’t define echo chambers but reveal systematic differences in political awareness
Echo chambers are widely acknowledged as a feature of online discourse and current politics: a phenomenon arising when people selectively engage with like-minded others and are shielded from opposing...
Discursive strategies of Chinese elders in intergenerational conflicts: A critical discourse analysis of mediation television programs in China
Research on conflict discourse highlights the value of a cross-cultural perspective and the need to explore its features across different cultural contexts. However, there is limited research on confl...
Rapid risk assessment to address emerging concerns of HPAI in raw and pasteurized milk
An outbreak of highly pathogenic avian influenza A, subtype H5N1, first reported in U.S. dairy cattle in March 2024, raised concerns of an emerging food safety threat from the virus in the milk supply...
Security importance of edge-IoT ecosystem: An ECC-based authentication scheme
Despite the many outstanding benefits of cloud computing, such as flexibility, accessibility, efficiency, and cost savings, it still suffers from potential data loss, security concerns, limited contro...
Speech-in-noise recognition as a predictor of academic achievement
Background The capacity to listen effectively greatly influences learning. Speech understanding in noise, a crucial element of listening, involves the ability to comprehend and interpret speech despit...
A location privacy protection method based on blockchain and threshold cryptography
To address privacy leakage risks arising from low collaborative user engagement, third-party trust deficits, and insufficient collaboration timeliness in location-based services (LBS), this paper prop...
Localization and characterization of cutaneous neurogenic inflammation in acute gastric mucosal injury in rats: A possible morphological explanation for visceral sensitization?
This investigation transcends traditional methodologies by providing a quantitative analysis of the dynamic relationship between visceral pathologies and neurogenic spots, employing an acute gastric m...
Diagnostic performance of microvascular flow imaging for noninvasive assessment of liver fibrosis in chronic liver disease
Background and aims Chronic liver disease (CLD) represents a significant global health challenge necessitating the evaluation of liver fibrosis. This study aimed to evaluate the di...
Model parameterization of robotic systems through the bio-inspired optimization
The accurate modeling of dynamic systems, particularly robotic ones, is crucial in the industry. It enables simulation-based approaches that facilitate various tasks without requiring the physical sys...
MAGNET-seq: A tandem PCR and hybrid capture method for enhanced target enrichment
Hybrid-capture based target enrichment and multiplex PCR methods enhance sequencing efficiency by focusing on specific genomic regions, while struggling to enrich tens of regions spanning hundreds to...
Spatial autocorrelation of environmental factors influencing dengue outbreaks using Moran’s I: A study from Nepal (2020–2023)
Background Dengue fever, a mosquito-borne viral infection caused by the dengue virus, has become a significant global public health concern, especially in tropical and subtropical regions. Nepal, with...
Associations between serum lipid levels and the macular retinal volumes in patients with diabetes
Purpose Macular retinal volumes can be measured by optical coherence tomography (OCT). However, the underlying pathogenesis was obscure. We compared the OCT and serum lipid data in participants with o...
Development of a patient/proxy-reported instrument for pediatric antibiotic-associated diarrhea
Objective To develop and validate a patient/proxy-reported measure of the incidence and severity of pediatric antibiotic-associated diarrhea (PAAD) in inpatient and outpatient settings. Methods A pa...
Crop evapotranspiration and water productivity in Loess Plateau: A case study of Shanxi province based on SEBAL model
This study focuses on Shanxi Province, located in the typical rain-fed agricultural region of the Loess Plateau, where farmland water reserves are limited and water scarcity is a significant challenge...
Acceptability of pre-exposure prophylaxis and associated factors among HIV-negative young men in Kagwara fishing community-Serere district, Uganda: A cross-sectional study
Background Despite the potential efficacy of Pre-Exposure Prophylaxis (PrEP) in reducing HIV risk, Oral PrEP acceptability remains strikingly varied by populations and locations. We assessed PrEP acce...
Dating ancient manuscripts using radiocarbon and AI-based writing style analysis
Determining by means of palaeography the chronology of ancient handwritten manuscripts such as the Dead Sea Scrolls is essential for reconstructing the evolution of ideas, but there is an almost compl...
Effects of cryotherapy on function, pain intensity, swelling, and dorsiflexion range of motion in acute ankle sprain: Protocol for the FROST randomised controlled trial
Background Cryotherapy is a low-cost treatment option recommended by clinical practice guidelines in acute ankle sprain. However, the current quality of the evidence that supports cryotherapy is still...
Production of probiotic garden cress (Lepidium Sativum) using Bifidobacterium Bifidum and its evaluation of nutritional value, biocontrol and growth rate ability
Probiotics are one of the most beneficial elements in human health. Several studies have confirmed the health benefits of probiotics. The consumption of fermented vegetables is widespread worldwide an...
Genome-wide DNA methylation analysis of hippocampal tissue in a murine model of attention deficit-hyperactivity disorder
Attention Deficit-Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with a prevalence around 5% in children and adolescents and 2.5% in adults. Recent reports using GWAS approaches have i...
Quality of insulin obtained from hospital and community pharmacies in Mwanza Tanzania: A cross-sectional study
Background Insulin, a peptide hormone crucial for diabetes management, necessitates strict storage (2-8oC) to maintain concentration, as per regulatory guidelines (e.g., USP, WHO). Degradation can occ...