PLoS ONE
Articles in this Issue
Multivariate analyses of Aurignacian and Gravettian personal ornaments support cultural continuity in the Early Upper Palaeolithic
Traditionally, lithic artefacts have served as the principal proxy for the definition of archaeological cultures in the Upper Paleolithic. However, the culture-historical framework in use, constructed...
FM3VCF: A software library for accelerating the loading of large VCF files in genotype data analyses
The increasing size of genotype data has led to the loading of VCF files becoming a computational bottleneck in various analyses, including imputation and genome-wide association studies (GWAS). To ad...
A comparative study of various statistical and machine learning models for predicting restaurant demand in Bangladesh
Precise demand forecasting has become crucial for merchants due to the growing complexity of client behavior and market dynamics. This allows them to enhance inventory management, minimize instances o...
Research on optimal scheduling of integrated energy system based on improved multi-objective artificial hummingbird algorithm
To accelerate energy efficiency improvement and green transition in industrial parks while addressing energy utilization and carbon reduction requirements, this study proposes a low-carbon economic di...
Dynamically weighted graph neural network for detection of early mild cognitive impairment
Alzheimer’s disease (AD) is a prevalent neurodegenerative disease that primarily affects the elderly population. The early detection of mild cognitive impairment (MCI) holds significant clinical impor...
Global burden and regional disparities of rheumatoid arthritis among the working-age population: A comprehensive analysis from 1990 to 2021 with projections to 2040
Objective To evaluate the age-standardized incidence (ASIR), prevalence (ASPR), death (ASDR), and disability-adjusted life year (DALY) rates of rheumatoid arthritis (RA) among the working-age populati...
Achieving green agricultural development: Analyzing the impact of agricultural non-point source pollution on food security and the regulation effect of environmental regulation
Food security is the lifeline of national security. It is not only an important cornerstone for world peace, stability, and development, but also the core driving force for promoting the green develop...
Polypyrimidine tract binding proteins PTBP1 and PTBP2 associate with distinct proteins and have distinct post-translational modifications in neuronal nuclear extract
RNA binding proteins play an important role in regulating alternative pre-mRNA splicing and in turn cellular gene expression. Polypyrimidine tract binding proteins, PTBP1 and PTBP2, are paralogous RNA...
Nutritional status of healthcare professionals in primary health and social care
Balanced nutrition is crucial for healthcare workers’ health and performance. Despite extensive knowledge of healthy eating, they face organizational and behavioral barriers leading to suboptimal diet...
Adaptation of PCR-based library preparation for MGI platform for cancer mutation testing in clinical setting
MGI platforms hold promise to become a widespread instrument for various clinical next-generation sequencing applications, from whole genome sequencing to COVID-19 genotyping. However, in the clinical...
Patient safety culture in public hospitals of Ethiopia: A systematic review and meta-analysis
Background Patient safety is a major health care challenge and is an issue of global concern. Poor healthcare system in Ethiopia, alongside increasing concerns for safety and patient safety culture, p...
Shear performance evaluation of sustainable concrete beams containing rice husk ash and carbon nanotubes as cement replacement
The utilization of rice husk ash (RHA) as a cement substitute in concrete can mitigate the environmental issues caused by concrete production. This study is the first investigated the effect of differ...
Growth dynamics and protein-expression of Escherichia coli serotypes O26:H11, O111:H8 and O145:NM in the bovine rumen
To adapt to the ruminal environment, Shiga toxin-producing Escherichia coli (STEC) O157:H7 (O157) expresses proteins involved in survival rather than virulence. Additionally, STEC O157 strains exhibit...
The third intracellular loop of Drosophila Lilipod is required for protein function in vivo and can mediate protein-protein interactions in vitro
The evolutionarily conserved Lipocalin-Interacting Membrane Receptor (LIMR) family (InterPro: IPR006876) consists of transmembrane (TM) proteins characterized by 9 TM domains (TMDs). Their reported bi...
Retraction: Determining the appropriate level of farmyard manure biochar application in saline soils for three selected farm tree species
“I’ve not been knocked out, so I’ll probably be fine:” Amateur Rugby players do not know the risks they are taking
Concussion is prevalent in British amateur Rugby and there is currently contradicting evidence of the attitudes and knowledge of concussion in Rugby players. As such this study aimed to investigate th...
Enhancing time synchronization between host and node stations using a fuzzy proportional-integral approach for EtherCAT-based motion control systems
Real-time synchronization for the servo system becomes one of the most popular themes in the Industry 4.0 era. Each connected agent publishes its data and mutual information in the shared protocol whi...
Conservation of fish diversity in protected sites and adjacent fishing areas of the Southern Mexican Pacific Ocean
The global decline in marine biodiversity is accelerating, prompting Mexico’s government to establish marine protected areas to regulate human activities. The objective of this study was to test wheth...
The nexus between environmental concern and future childbearing aspirations among university students in Bangladesh
This study investigates the relationship between environmental concerns and future childbearing aspirations among university students in Bangladesh. It included 380 final-year and master’s students fr...
Principal fitted component framework for robust support vector regression based on bounded loss: A simulation study with potential applications
The inferential results regarding estimates of Support Vector Regression (SVR) are highly influenced by anomalies and ill-conditioned predictors. Excessive dimensions of data also make the model compl...
In-hospital mortality outcomes of favipiravir in patients with moderate to severe COVID-19 infection: An emulated target trial using real-world data from the largest field hospital in Thailand
Background Favipiravir, an antiviral agent, has been widely used to treat COVID-19 due to its potential mechanism of action, despite limited evidence of its efficacy in moderate to severe cases. Aim...
Gender disparities in bladder cancer: A population-based study on life expectancy and health spending in Asia
Background The aim of this study was to elucidate the disparities in life expectancy, loss-of-life expectancy, and lifetime medical expenditure between sexes in patients with bladder cancer. Methods...
Identification of key genes and signaling pathways of liver cancer and model construction for prognosis and diagnosis based on bioinformatics analysis
Objective This study aims to identify key genes, biomarkers, and associated signaling pathways involved in liver cancer progression by analyzing differentially expressed genes (DEGs) between normal an...
Technical report: Efficient and accurate assessment of neurite outgrowth in spiral ganglion explants using Sholl analysis and repeated measurement ANOVA
Cultivating three-dimensional spiral ganglion explants is a well-established in-vitro assay for assessing the neurotrophic potential of compounds. The manual neurite measurement remains common but hin...
The effect of Nigella Sativa emulgel on episiotomy wound healing and pain intensity in primiparous women: A triple-blind randomized controlled trial
Background Episiotomy, a common surgical procedure during childbirth, often leads to complications such as pain, infection, and delayed healing. Nigella sativa has demonstrated anti-inflammatory and w...