PLoS ONE
Articles in this Issue
Prediction of future aging-related slow gait and its determinants with deep learning and logistic regression
Background Identification of accelerated aging and its biomarkers can lead to more timely therapeutic interventions and decision-making. Therefore, we sought to predict aging-related slow gait, a know...
The effects of rifaximin and lactulose on the gut-liver-brain axis in rats with minimal hepatic encephalopathy
Background The principal therapeutic agents for minimal hepatic encephalopathy (MHE), which focus on the modulation of the gut microbiota, include lactulose and rifaximin; however, the precise mechani...
How the natural environment affects psychological recovery: A case study in Changsha, China
Previous research has demonstrated the role of urban forest parks in the recovery of human psychological well-being, but there is a lack of explanation of the “how” and “why” of experiences in urban f...
Monetary policy effect on income and wealth inequality mechanism
Since the 1990s, global income and wealth inequality has increased significantly, especially in developing countries, where the imbalance in wealth distribution has become increasingly prominent. This...
Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine
Oncolytic reovirus is a potential therapeutic for colorectal cancer patients with a mutant KRAS gene. Reovirus hijacks the autophagic machinery and preferentially induces apoptosis in patients with a...
Socioeconomic inequalities in access to maternal healthcare in South-Asian countries: A systematic review
Background Despite numerous efforts, South Asia is the second most leading region for maternal mortality and morbidity. Although there have been notable advancements on this continent, progress in mat...
PIFR: A novel approach for analyzing pose angle-based human activity to automate fall detection in videos
Falls pose a significant health risk for elderly populations, necessitating advanced monitoring technologies. This study introduces a novel two-stage fall detection system that combines computer visio...
Quantitative evaluation and obstacle factor diagnosis of drug regulatory capacity in China
Objective To quantitatively evaluate the drug regulatory capacity in China, aiming to optimize the drug regulatory system, precisely enhance local regulatory effectiveness, and reduce regional regulat...
Tracing CO2 sources in urban and rural areas characterized by different land-use patterns using carbon isotopes
Air samples were collected from urban and rural areas of Korea with different land-use patterns between October 2022 and April 2023 to identify the sources of atmospheric CO2. We analyzed representati...
Anemia, micronutrient deficiency, and elevated biomarkers of inflammation among women and children in two districts in the Northern Region of Ghana: A pilot study
Introduction Previous data had shown a high prevalence of anemia and various micronutrient deficiencies (MNDs) in the Tolon and Kumbungu districts. We aimed to reassess these outcomes among lactating...
Ultra-massive fluid transfusion in adult liver transplant recipients: A single center observational study
Introduction Patients undergoing liver transplantation may require large volumes of fluid to maintain hemodynamic stability and treat coagulopathy. This study aimed to determine the prevalence of ultr...
Towards implementation of independent calculation-based dose verification in proton therapy
Background Proton therapy offers precision in targeting tumors while minimizing damage to surrounding healthy tissues. Independent dose calculation is a secondary dose validation tool for patient-spec...
Could calisthenic exercises improve maximal exercise capacity, peripheral muscle strength and quality of life in dyslipidemia?
Background Regular exercise improves cardiovascular health through regulating the plasma lipoprotein profile. But the effects of different exercise modalities on exercise capacity, muscle strength and...
Identification of Therapeutic Targets in Autism Spectrum Disorder through CHD8-Notch Pathway Interaction Analysis
Background Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with a rising global prevalence. Mutations in the CHD8 gene have been implicated in ASD, yet the underlying molecular...
Efficacy of NAMPT inhibition in T-cell acute lymphoblastic leukemia
Novel agents targeting upregulated signaling pathways are needed to improve outcomes in T-cell acute lymphoblastic leukemia (T-ALL), since conventional cytotoxic chemotherapy regimens have reached the...
Inflammatory cells and remodeling in bronchial biopsies from COPD patients and controls
Background The understanding of inflammation and remodeling in the bronchial wall of COPD patients with varying disease severity remains incomplete. Methods 35 healthy controls and 47 volunteer COPD...
Aspirations to study medicine, perceptions of a good doctor, and their influence on specialty choice among medical students
Background Specialty decision-making among medical students reflects a complex interplay of motivations, evolving perceptions, and experiences during medical training. This study explores how students...
Abies sachalinensis naturally growing at a sedimentary site acquires iron tolerance via detoxicants production, elemental transfer adjustment, and root endophytic Phialocephala bamuru producing siderophores
Abies sachalinensis naturally growing in heavy metal-rich sedimentary sites exhibits heavy metal tolerance. Although root endophytes increase heavy metal tolerance in various plants, their effects on...
Lymphocyte immunophenotype in dogs with immune-mediated hematologic disease
Immune-mediated hematologic diseases (IMHD) including immune-mediated hemolytic anemia (IMHA) and immune thrombocytopenia (ITP) can cause severe disease in dogs. The underlying immune system abnormali...
Physical model of serum supplemented medium flow in organ-on-a-chip systems
Creating a physiologically relevant shear stress in organ-on-a-chip (OOC) devices requires careful tailoring of microfluidic flow parameters. Currently, it is fairly common to use a simple approximati...
Body image, obesity, and sexual coercion: Impacts on depression among students at a Nigerian university
Introduction University students face a variety of challenges, including mental health issues, which are often compounded by societal and individual factors such as body image concerns, obesity, and e...
Optimizing solar drying efficiency: Effects of PCM, and IR on energy and exergy performance
This study investigates the drying behavior of potatoes using a hybrid solar dryer equipped with a Compound Parabolic Concentrator (CPC) collector, Phase Change Materials (PCM), and Infrared Radiation...
Towards a new perspective: Exploring the variability of conditional risk factors for multimorbidity susceptibility among older adults in India
Background There is a lack of substantive evidence on the epidemiology of multimorbidity in low and middle-income countries (LMICs). India is also undergoing through the major demographic shift marked...
Latent class analysis of depression among patients with non-small cell lung cancer after surgery: A cross-sectional study
Background Depression exhibits heterogeneity. However, limited research has explored this heterogeneity in patients with non-small cell lung cancer (NSCLC) after surgery from a person-centered perspec...
From detached to alarmed: How eco-emotion profiles predict concern and sacrifice for the planet
The rapid degradation of the environment is one of our greatest challenges in the 21st century. To avoid the worst consequences, human behavior change is required. The current study investigated how f...