PLoS ONE
Articles in this Issue
Prehospital delay and associated factors among stroke patients in Africa: A systematic review and meta-analysis
Introduction Stroke is one of the leading causes of death and disability, predominantly affecting low- and middle-income countries. Timely intervention following stroke onset is critical for reducing...
Correction: Expression of genes with biomarker potential identified in skin from DSLD-affected horses increases with age
The effects of integrating the Manchester Pain Management Model and empowerment education on postoperative rehabilitation after cesarean section: A comprehensive intervention study
Purpose To evaluate the effect of combining the Manchester Pain Management Model (MPMM) with the enabling education model as a comprehensive intervention in maternal rehabilitation after cesarean sect...
Design, synthesis, in-vivo, and in-silico studies of 1,2,3-triazole tethered derivatives of morphine as novel anti-nociceptive agents
Due to the use of morphine as a well-known analgesic, a semi-synthesis of its newer triazole derivatives was performed in this project. Several derivatives were analyzed via molecular docking and a se...
Brain microdialysis to assess trace elements dynamics in traumatic brain injury: An exploratory study
Background Trace elements (TEs) status alterations in the brain have been linked to neurodegenerative diseases. However, data on TEs in living humans and in the post-traumatic conditions are scarce. S...
Determinants of hypertensive crisis among hypertensive patients at adult emergency departments of public hospitals in eastern Ethiopia, 2023: A case-control study
Background Hypertensive crisis is a life-threatening condition requiring urgent medical intervention. Identifying key determinants is essential for effective prevention and management. This study aime...
Can anthropomorphic design in beverage packaging enhance impulse buying intention? Amazing visual and verbal cues!
The anthropomorphic design of beverage packaging has gained significant attention as an innovative marketing strategy. This study systematically examines how anthropomorphic visual and verbal cues in...
RRFNet: A free-anchor brain tumor detection and classification network based on reparameterization technology
Advancements in medical imaging technology have facilitated the acquisition of high-quality brain images through computed tomography (CT) or magnetic resonance imaging (MRI), enabling professional bra...
Drug repositioning for pan-cancers of the digestive system: Identification of amonafide and BX795 as potential therapeutics via integrative Omics analysis
Background Digestive system cancers, including esophageal, gastric, colorectal, pancreatic, hepatocellular, and biliary tract cancers, constitute a major global health challenge. Despite therapeutic a...
Understanding the combined symptom medication score in the light of contexts and mechanisms
Background In a clinical trial of allergen‐specific immunotherapy for allergic rhinoconjunctivitis, the Combined Symptom Medication Score (CSMS) was utilized as the primary endpoint. This was aligned...
Graph attention networks based multi-agent path finding via temporal-spatial information aggregation
An effective Multi-Agent Path Finding (MAPF) algorithm must efficiently plan paths for multiple agents while adhering to constraints, ensuring safe navigation from start to goal. However, due to parti...
Metformin modulates the unfolded protein responses, altering lifespan and health-promoting effects in UPR-activated worms
Metformin has been demonstrated to extend lifespan in various model organisms, and its molecular effects are observed in the cytoplasm and multiple organelles, including mitochondria. However, its ass...
High prevalence of Duck Hepatitis B virus-associated coinfection in Southwest China
Currently, five types of duck hepatitis viruses have been documented, and they are all associated with liver disorders. However, the prevalence of their coinfections involving these viruses remains la...
Real-world safety profile of live attenuated Japanese encephalitis vaccine before and after the vaccine administration law
Purpose Live attenuated Japanese encephalitis vaccine (JEV-L) was included in the Expanded program on immunization on Immunization (EPI) in 2008 and has had a satisfactory effectiveness and safety pro...
Transcriptomic profiling of pancreatic neuroendocrine tumors: dysregulation of WNT, MAPK, PI3K, neddylation pathways and potential non-invasive biomarkers
The study aimed to identify altered signaling pathways and potential non-invasive biomarkers for pancreatic neuroendocrine tumors (PanNETs) through transcriptomic profiling of tumor tissues. The analy...
‘I think youtube’s turning me into a flat earther’: Social media’s role in ex-conspiracy theorists entering and exiting anti-scientific communities
Conspiracy beliefs erode trust in science and lead to negative effects on public health and other science-related behaviours and political discourse. Despite extensive research on conspiratorial think...
Propensity to childhood anxiety and depression due to exposure to adversity: A multidimensional construct
Children and adolescents are increasingly susceptible to issues related to anxiety and depression symptoms. The literature does not present a consensus on the composition of indicators that make predi...
Association between the early use of beta-blocker and the risk of sepsis-associated acute kidney injury: A retrospective cohort study using the MIMIC-IV database
Background Sepsis-associated acute kidney injury (SA-AKI) is a common and life-threatening complication in critically ill patients. Studies have shown that the use of beta-blockers improves hemodynami...
Influence of multi-species data on gene-disease associations in substance use disorder using random walk with restart models
A major challenge lies in discovering, emphasizing, and characterizing human gene-disease and gene-gene associations. The limitations of data on the role of human gene products in substance use disord...
Flexi-YOLO: A lightweight method for road crack detection in complex environments
Road crack detection is critical to global infrastructure maintenance and public safety, and complex background environments and nonlinear damage crack patterns challenge the need for real-time, effic...
Marine fishes exhibit exceptional variation in biofluorescent emission spectra
Biofluorescence is a phylogenetically widespread phenomenon among marine fishes, yet the phenotypic diversity in fluorescent emission wavelengths (e.g., green, red) remains poorly studied across the b...
Objective assessment of tinnitus laterality
Tinnitus is a condition which involves hearing sounds not present externally. This common condition can lead to a range of symptoms, including depression, resulting in a severe impact on quality of li...
Identification and validation of differentially expressed genes in intramuscular fat metabolism in Guizhou yellow chickens using RNA-Seq analysis
Intramuscular fat (IMF) content is crucial for meat quality, and genetic, environmental, and nutritional factors influence its deposition. This study aims to identify genes involved in the regulation...
JAK inhibitor withdrawal causes a transient pro-inflammatory cascade: A potential mechanism for major adverse cardiac events
Objective Our objective was to define the effect of JAK inhibitor (JAKinib) withdrawal on JAK/STAT biochemical response in the context of systemic rheumatic diseases. Methods We tested Type I (bind...
Factors modulating the impact of the COVID-19 pandemic on posttraumatic stress symptomatology of the Spanish healthcare workers: A cohort study
Introduction The COVID-19 pandemic generated a global health crisis that significantly impacted healthcare systems and professionals. Healthcare workers were exposed to high levels of psychological di...