PLoS ONE
Articles in this Issue
The YoungFitT project: Study protocol for a randomized mixed-methods trial of physical exercise and mind-body interventions, with or without virtual reality, in university students
Background Mental health issues among young university students have increased in recent years, driven by academic stress and sedentary lifestyles. The YoungFitT Project aims to explore well-being str...
An analysis of spatial distribution characteristics and driving factors of traditional villages in the Loess Plateau
By revealing the spatial distribution characteristics and driving mechanisms of 1,027 traditional Chinese villages in the Loess Plateau, as announced in six batches up to 2023, this article provides a...
Correction: Exploring a method for extracting concerns of multiple breast cancer patients in the domain of patient narratives using BERT and its optimization by domain adaptation using masked language modeling
Association between physical activity level and cardiovascular disease: An empirical analysis based on CHARLS data in 2018
Objective Cardiovascular disease (CVD) was a global public health challenge. This study aimed to investigate the association between physical activity level (PAL) and CVD among middle-aged and older a...
Non-exchangeable hydrogen (δ2H) stable isotope ratios in fauna provide enhanced dietary, isotopic niche and home range reconstruction at Aqaba Castle, Jordan
Bone collagen of terrestrial and marine animals (n = 218) recovered from Ottoman period contexts at Aqaba Castle, Jordan (16th–19th centuries CE), were analyzed for δ13C, δ15N, and δ2H isotope ratios....
Preparation of cardan joint by selective laser sintering and properties of polyamide-12 and portland cement powder mixture
A homogeneous mixture of polyamide-12 (PA-12) and Portland cement (PC) powder material was prepared using the Sinterit sifter. Many techniques were used to detect morphological and functional properti...
Global, regional, and national prevalence and trends of gynecological diseases among women of childbearing age from 1990 to 2021: An analysis of the global burden of disease study 2021
Purpose The global prevalence and trends of gynecological diseases (GDs) among women of childbearing age (WCBA) remain unclear and may be underestimated. This study aims to evaluate the prevalence of...
Incidence and predictors of preterm neonatal mortality at public hospitals in Eastern Ethiopia: A prospective follow-up study
Introduction Preterm birth is a major clinical problem, affecting 15 million births every year worldwide. It is the largest cause of death in children under the age of five. Even though different stud...
Mapping strategies, components, and theories used in health education and physical activity interventions to prevent cardiovascular diseases in adults living with HIV: A scoping review protocol
Introduction Cardiovascular diseases (CVDs) have become the most significant contributor to non-HIV/AIDS-related deaths in people living with HIV (PLWH). The increased risk for CVDs in PLWH is attribu...
Antimicrobial activity of Origanum vulgare L. essential oil and its effects on fungal gene expression
Origanum vulgare L. (oregano) essential oil showed strong antimicrobial potential, effectively inhibiting the growth of various microorganisms. In our study, oregano essential oil inhibited the growth...
Non-linear association of cardiometabolic index with gallstone disease in US adults: A cross-sectional study
Objective Obesity and disorders of lipid metabolism are key factors in gallstone formation. The cardiometabolic index (CMI) is a new marker combining obesity indicators (WHtR) and lipid levels (TG/HDL...
OpDetect: A convolutional and recurrent neural network classifier for precise and sensitive operon detection from RNA-seq data
An operon refers to a group of neighbouring genes belonging to one or more overlapping transcription units that are transcribed in the same direction and have at least one gene in common. Operons are...
Mechanism of Astragaloside-Brucea javanica oil nanoemulsion against oral squamous cell carcinoma through CDK1/MTFR2: Network pharmacology, bioinformatics, and experimental studies
Objective This study aims to investigate the core target of Astragaloside-Brucea javanica oil nanoemulsion (AS/BJO-NEs) against oral squamous cell carcinoma (OSCC) through network pharmacology, bioinf...
Epidemiological and clinical analysis, and outcomes of tuberculosis co-infection among people living with HIV in Türkiye (2014–2024) ClinSurv HIV cohort: A large case series
Background Tuberculosis (TB) is one of the most common opportunistic infections in people living with HIV (PLHIV). Mycobacterium tuberculosis may cause more TB in all stages of HIV infection than in t...
Three-dimensional multiple object tracking (3D-MOT) performance in young soccer players: Age-related development and training effectiveness
Objectives The aim of the present study is to examine the developmental trajectory of 3D-MOT performance in young soccer players, and to investigate the age-related 3D-MOT performance training effect....
Derivation of a novel multi‐gene prognostic model based on regulated cell death pathways in acute myeloid leukemia: A comprehensive bioinformatic analysis integrating gene expression, mutation profiling, and immune infiltration
Background Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy with dismal survival outcomes, where dysregulation of regulated cell death (RCD) pathways plays a pivotal role in...
Public education during epidemics of infectious diseases: A national mixed-method study with parallel convergent design in a low and middle-income country
Introduction Proper and effective public education during epidemics of infectious diseases can have a key effect in controlling epidemics and reducing their complications. Therefore, the present study...
Exposure to maternal nicotine in utero and/or via lactation alters craniofacial development in mice
The Center for Disease Control’s National Birth Defects Prevention Study data suggests that maternal nicotine use may increase the incidence of craniofacial birth defects and growth anomalies like cra...
Machine learning combining external validation to explore the immunopathogenesis of diabetic foot ulcer and predict therapeutic drugs
Diabetic foot ulcer (DFU) is a severe complication of diabetes, often leading to amputation due to poor wound healing and infection. The immune-related pathogenesis of DFU remains unclear, and therape...
Correction: Fluorescent reporter plasmids for single-cell and bulk-level composition assays in E. faecalis
Monitoring, surveillance, antimicrobial resistance and genetic diversity analysis of non-typhoidal Salmonella in South Africa from 1960–2023 from animal and animal products
Salmonellosis remains one of the most frequently reported foodborne diseases globally, with the highest burden in low-resource areas. The millions of deaths caused by Nontyphoidal Salmonella (NTS) inf...
Static load test and bearing capacity analysis of broken line pretensioned prestressed concrete I-beam
The construction technology of broken line pretensioned method, which is suitable for long-span bridges, can greatly improve the flexural strength of concrete members. To study the mechanical performa...
Prevalence and diagnostic reliability of BRAF, RAS mutations, and RET/PTC rearrangements in a Latin American public health service population with thyroid nodular disease
Despite their high prevalence and generally benign nature in most cases, the investigation of thyroid nodules still presents potential diagnostic pitfalls, especially in cases with indeterminate cytol...
Association between serum anion gap and all-cause mortality in critically ill patients with diabetic kidney disease: Analysis of the MIMIC-IV database
Background Diabetic kidney disease (DKD) is one of the most common diabetic complications and is closely related to metabolic acidosis. The serum anion gap (AG), an important index of acid-base balanc...
Evolutionary origins and life-history correlates of coloniality in the epiphytic fern genus Platycerium (Polypodiaceae)
Many animals live in cooperative groups comprised of morphologically differentiated individuals that subdivide labour to help the group persist in harsh, unpredictable environments. Recently it has be...