PLoS ONE
Articles in this Issue
Medical costs for patients with rheumatoid arthritis who have comorbid diabetes mellitus
Objectives To evaluate medical costs and resource use in patients with rheumatoid arthritis (RA) with and without diabetes mellitus (DM). Methods Data were obtained from the Japan Medical Data Cente...
Biochemical analysis of human eIF4E-DCP2 interaction: Implications for the relationship between translation initiation and decapping
All eukaryotic mRNAs bear a 7-methylguanosine cap on their 5’ end. The 5’ cap enables mRNA translation by binding directly to eIF4E; which further recruits other factors and the 40S ribosome. Addition...
Investigating the content and processes of patient-derived quality of care indicators for those affected by multiple long-term conditions (MLTC): A scoping review protocol
Background People living with multiple long-term conditions (MLTC) are reported to have poorer quality of life, worse health outcomes, and higher health-related expenses compared to those with singula...
Preparation and characterization of a novel magnetic nano adsorbent for removal of metal ions
As a result of global urbanization and industrialization, heavy metals are one of the hazardous contaminants facing the world. The adsorption process using agricultural wastes can achieve one of the s...
The hidden influence: Medical students’ knowledge and attitude of conflict of interest–A cross-sectional study in Jeddah, Saudi Arabia
Introduction Conflicts of interest (COI) pose ethical challenges in medical education and clinical practice, potentially influencing decision-making. While COI policies and education vary globally, in...
Biochemical neuroplasticity in the cerebellum after physical exercise: Systematic review and meta-analysis
Background Neuroplasticity is the central nervous system’s (CNS) capacity to adapt to injuries or environmental changes. Biochemical neuroplasticity is one such adaptation that may occur in response t...
Impact of energy consumption on environment sustainability in upholding ESG practices in Malaysia: Evidence from electricity supply company
This study aims to examine the impact of energy consumption, i.e., coal and gas, on environmental sustainability by utilizing CO2 emissions as a proxy to emphasize Environmental, Social, and Governanc...
Normal-weight obesity in high-altitude youth: Gender disparities and protective effects of native adaptation
Background While high altitude has been associated with reduced muscle mass, its effects on fat mass remain controversial, with studies reporting both fat accumulation and loss. Normal weight obesity...
The Multiple Platforms Effect (MPE): A quantification of how exposure to similarly biased content on multiple online platforms might impact users
Over the past decade, controlled studies have identified nearly a dozen new forms of manipulation that can be used by search engines, social media platforms, microblogging platforms, and intelligent p...
Decoding community proximity discourse: A mixed-methods comparative analysis of online local and national newspapers in Romandy, Switzerland
This paper presents a mixed-method approach to analyzing news media, combining quantitative linguistic metrics with qualitative discourse frameworks. We first extract linguistic features such as quota...
Association between oxidative balance score and systemic immune-inflammation index: NHANES 2003–2018
Background As we all known oxidative stress and inflammation were interdependent and interconnected. Oxidative balance score (OBS) could assess the antioxidant capacity of an individual’s body. The pu...
Does microcredit for the poverty-alleviated population have an income-increasing effect? Also on the “Raising the Low” effect
Promoting the continuous income increase of the poverty-alleviated population has become one of the key tasks to consolidate the achievements of poverty alleviation, promote rural revitalization and a...
Cadmium-induced impairment in growth, photosynthetic apparatus and redox regulation in green amaranth (Amaranthus viridis L.) plant attenuated by salicylic acid and methyl jasmonate
The hazardous Cadmium (Cd) contamination in vegetables from anthropogenic Cd-abundant agroecosystems is a decisive threat to plants and human health. This study examined the prospective roles of salic...
Identification of the Francisella novicida FTN_0096 as a factor involved in intracellular replication and host response
Francisella tularensis is the causative agent of the zoonotic disease tularemia. We investigated a pathogenic factor of F. tularensis subsp. novicida (F. novicida). Accordingly, we established a novel...
Adopting Soft Logic to enhance an Adizes tool: A comprehensive approach to represent the evaluation of management styles
Management skills assessment has become increasingly complex in today’s digital age, as these skills are multi-dimensional and require a nuanced approach. Beyond evaluating each dimension independentl...
Perceived power dynamics in nursing education on students’ learning experience in Ghana
Introduction Educator-student connectedness is where students can thrive, even amid failure, preserving their worth and self-dignity. Every relationship may have challenges, which is no different in n...
International students’ experiences on speaking and writing skills in language learning processes in higher education
Although speaking and writing skills play a crucial role in second language acquisition, studies focusing specifically on the challenges faced by international students learning Turkish as a foreign l...
The role of music in ADHD: A multi-dimensional computational and theoretical analysis
Attention-Deficit Hyperactivity Disorder (ADHD), a neurodevelopmental disorder affecting children and adults worldwide, has seen a significant rise in diagnoses and medication prescriptions in recent...
Impact assessment for just transition of protein production systems
Understanding the impacts of protein production systems is necessary to plan the just transition of food systems. We analysed 285 studies to assess the impacts of 13 protein systems across 25 indicato...
Meta-regression to explain shrinkage and heterogeneity in large-scale replication projects
Recent large-scale replication projects (RPs) have estimated concerningly low reproducibility rates. Further, they reported substantial degrees of shrinkage of effect size, where the replication effec...
Pharmacogenomic insights into amlodipine response: the role of CACNA1D, CACNA1C, and TRIB3 variants in hypertensive patients
Hypertension affects over 1.28 billion individuals worldwide, yet response variability to calcium channel blockers (CCBs) like amlodipine remains a challenge. While pharmacogenomic studies have implic...
Recursive Objective Space Exploration (ROSE): A computationally efficient deterministic approach for bi-objective optimization
Bi-objective optimization problems arise when a process needs to be optimized with respect to two conflicting objectives. Solving such problems produces a set of points called the Pareto front, where...
Expression of Concern: Ontological Differences in First Compared to Third Trimester Human Fetal Placental Chorionic Stem Cells
The porphyran degradation system is complete, phylogenetically and geographically diverse across the gut microbiota of East Asian populations
The human gut microbiota can acquire new catabolic functions by integrating genetic material coming from the environment, for example from food-associated bacteria. An illustrative example of that is...
Loss of Ufsp1 does not cause major changes at the neuromuscular junction
UFMylation is a Ubiquitin-like post-translational modification involved in myriad of cellular processes. Enzymes involved in this pathway, including ligases and UFM1-specific proteases, are essential...