PLoS ONE
Articles in this Issue
Genotype distribution of human papillomavirus among women with cervical cancer stratified by HIV status in Tanzania
Background Cervical cancer (CC) is the leading cancer among women in Tanzania, especially among those between the ages of 15 and 44. The prevalence of high-risk Human papillomavirus (HR-HPV)-16/18 wom...
Bayesian robust symmetric regression for medical data with heavy-tailed errors and censoring
Bayesian symmetric regression offers a principled framework for modeling data characterized by heavy-tailed errors and censoring, both of which are frequently encountered in medical research. Classica...
Scalable quality control on processing of large diffusion-weighted and structural magnetic resonance imaging datasets
Thorough quality control (QC) can be time consuming when working with large-scale medical imaging datasets, yet necessary, as poor-quality data can lead to erroneous conclusions or poorly trained mach...
Study on bearing capacity of Mortise-tenon and joint-flange concrete assembled foundation of transmission line under combined load
Mortise-tenon and joint-flange assembled foundation has excellent application as a new type of slab concrete assembled foundation, but there is a lack of research on its bearing capacity. In order to...
Correction: Effects of a low-carbohydrate diet in adults with type 1 diabetes management: A single arm non-randomised clinical trial
Divergent trends in structural landscape connectivity from historic and potential future grassland conversion in Alberta, Canada
Grasslands across the Canadian prairies are crucial for maintaining biodiversity and ensuring landscape connectivity. In Alberta, a large portion of natural grasslands has been converted to agricultur...
CYP2B6*6 single nucleotide polymorphism among patients with uncomplicated malaria in Adjumani district, Uganda: Implications on efficacy of artemether-lumefantrine
CYP2B6, one of the most polymorphic enzymes, plays a major role in the metabolism of artemisinin and its derivatives. Variation in the frequency of the most common, yet functionally deficient CYP2B6*6...
Prevalence and associated factors for HIV, HBV and syphilis coinfections among pregnant women attending antenatal care in Tanzania
Background Coinfection with HIV, hepatitis B virus (HBV) and syphilis increases the risk of vertical transmission. Hence, affecting overall maternal health and child health outcomes. The Tanzanian gov...
Comparing variable and feature selection strategies for prediction - protocol of a simulation study in low-dimensional transplantation data
The integration of machine learning methodologies has become prevalent in the development of clinical prediction models, often suggesting superior performance compared to traditional statistical techn...
The impact of Evidence-Based Pharmacy on the quality of pharmaceutical care: A survey study
Applying Evidence-Based Pharmacy (EBPharm) principles is essential in pharmacy practice as it allows therapeutic decisions to be grounded in the best available scientific evidence. This approach enabl...
Prevalence and associated factors of pregnancy induced hypertension among pregnant women in public hospitals of Hadiya Zone, Central Ethiopia: A cross-sectional study
Background Pregnancy-induced hypertension is one of the global public health burdens contributing to several adverse perinatal outcomes. However, data on the prevalence and associated factors of PIH i...
Abdominal organ injury in cardiac arrest: Systematic literature review
Background Both cardiopulmonary resuscitation (CPR) and ischaemia could lead to abdominal organ injury. However, the importance of abdominal injury in cardiac arrest remains uncertain. We aimed to sys...
Monetary policy, debt maturity structure and corporate investment efficiency: Evidence from China
This paper examines the impact of monetary policy on corporate investment efficiency from the perspective of debt maturity structure by selecting data on Chinese non-financial listed firms and Chinese...
Analytical validation and sequencing coverage studies suggest that performance of a liquid biopsy assay is tumor agnostic (DNA-is-DNA)
Per regulatory and standard requirements (e.g., Clinical & Laboratory Standards Institute (CLSI) guidelines, United States Food and Drug Administration (FDA) correspondence), analytical validation...
LTR-Net: A deep learning-based approach for financial data prediction and risk evaluation in enterprises
Financial data prediction and risk assessment represent a complex multi-task problem that requires effective handling of time-series data and multi-dimensional features. Traditional models struggle to...
Long lasting effects of perinatal exposure to the Chlorpyrifos pesticide on sleep, breathing, and neuroinflammation in adult mice
Early-life exposure to environmental stressors may increase the risk of disease later in life. Chlorpyrifos (CPF), a widely used pesticide and acetylcholinesterase inhibitor, can cross the placental b...
Mental and physical health of US rural/urban caregivers of persons with dementia
Purpose Increased dependence on caregiving and limited access to healthcare services in rural US communities may contribute to worse mental and physical health in rural caregivers of persons with deme...
“Sun brings all things”: Sun and moon lore as biocultural knowledge on Aneityum island, Vanuatu
Across the Pacific, traditional myths and contemporary narratives describe the origins, animacy, and importance to daily human activities of the Sun and Moon. In Vanuatu, Indigenous local knowledge sy...
Cognitive impairment in Sjogren’s syndrome: Interplay between BACE1 activity, inflammatory blood biomarkers and neurocognitive testing
Background Sjogren’s syndrome (SS) is considered as a chronic, autoimmune disorder, that can present with various manifestations both intra and extra-glandular. Cognitive dysfunction is pivotal in rec...
Effects of a non-standard information leaflet on patient recruitment in acute care: Embedded cluster-randomised controlled trial
Background Recruiting study participants is a key component and major challenge in clinical research. Evidence shows that the design of written study information can influence recruitment success. How...
Static strengths of circular hollow section stub column strengthened with carbon fiber reinforced polymer
In previous studies, the strengthening effectiveness and feasibility of carbon fiber reinforced polymer (CFRP) were mainly evaluated through experimental research or numerical analysis. Although these...
Analysis and comparison of the bacterial σ54 regulon: Evidence of phylogenetic trends in gene regulation
While the role of σ54 in regulating genes involved in nitrogen metabolism, flagellar biosynthesis, and stress responses in Pseudomonadota is well established, its involvement in regulating alternative...
Knowledge transfer, knowledge gaps, and knowledge silos in citation networks
The advancement of science relies on the exchange of ideas across disciplines and the integration of diverse knowledge domains. However, tracking knowledge flows and interdisciplinary integration in r...
Burden of gram-positive bacteria from urinary tract infection: A four-year retrospective study in a tertiary health setting in southern Saudi Arabia
Background Antibiotic resistance is a worldwide problem causing significant health-related and economic losses. Gram-positive causes of urinary tract infections (UTIs) are usually underestimated or ov...
Hard input, soft management and student engagement: How institutional actions promote innovation ability and academic performance among top innovative talent
The training and cultivation of innovative talent, especially top-quality talent, cannot be explained fully by reference to a simple linear input‒output model. Research that can open the “black box” t...