PLoS ONE
Articles in this Issue
Impact of calcined bauxite aggregates on the polishing resistance and skid resistance performance of SMA-7 asphalt mixtures
High-performance anti-skid asphalt mixtures are essential for improving skid resistance and pavement durability. This study investigates the skid resistance performance of small-aggregate-size SMA-7 a...
Zebra optimization algorithm incorporating opposition-based learning and dynamic elite-pooling strategies and its applications
To address the limitations of the Zebra Optimization Algorithm (ZOA), including insufficient late-stage optimization search capability, susceptibility to local optima, slow convergence, and inadequate...
A new giraffe ossicone from Wolf Camp, Tunggur Formation, Inner Mongolia suggests a new genus in Bohlinini (Artiodactyla, Giraffidae)
The classic Middle Miocene Wolf Camp locality discovered in 1930 by the Third Asiatic Expeditions of the American Museum of Natural History has been long known to produce an extinct giraffe, Palaeotra...
A comparison of DNA methylation detection between HiFi sequencing and whole genome bisulfite sequencing in monozygotic twins with Down syndrome
DNA methylation, a key epigenetic modification, regulates gene expression and diverse cellular functions. Bisulfite sequencing (BS) remains the gold standard for methylation detection, while PacBio Hi...
Establishing a learning agenda for learning health system implementation and research in Canada
Health systems in Canada struggle to generate and use knowledge to improve equity-centred quadruple aim measures, resulting in care that is misaligned with local contexts. Learning Health Systems (LHS...
Role of G-protein-coupled receptor kinase 4 on the dysfunction of renal Mas receptor in hypertension
The angiotensin converting enzyme 2/angiotensin-(1–7)/Mas receptor axis plays an important role in the regulation of blood pressure. G protein-coupled receptor kinase 4 (GRK4) has attracted more atten...
Correction: Associations between diet quality, demographics, health conditions and spice and herb intake of adults with chronic kidney disease
Prevalence of HIV drug resistance, its correlates and common mutations among people living with HIV failing on ART in northern Uganda: A cross-sectional study
Background HIV drug resistance (HIVDR) poses a challenge to managing people living with HIV (PLHIV), particularly among those experiencing virological failure (VF). The West-Nile region of Uganda face...
DPRM: DeBERTa-based potential relationship multi-headed self-attention joint extraction model
Traditional entity-relationship joint extraction models are typically designed to address generic domain data, which limits their effectiveness when applied to domain-specific applications such as man...
Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization
Background Subarachnoid haemorrhage (SAH) poses a life-threatening risk, contributing to half of all haemorrhagic strokes, with aneurysmal SAH (aSAH) affecting approximately 6 individuals per 100,000...
Longitudinal tract-based spatial statistics analysis of white matter diffusivity changes and cognitive decline during the transition from MCI to Alzheimer’s disease
Longitudinal studies that analyze the changes in the axial diffusivity (AxD) and radial diffusivity (RD) values over time can elucidate the progression of white matter damage and its causal relationsh...
Leveraging deep learning for the detection of socially desirable tendencies in personnel selection: A proof-of-concept
We propose a deep learning-based method for detecting Socially Desirable Responding (SDR)—the tendency for individuals to distort questionnaire responses to present themselves in a favorable light. Ou...
Correction: Examining the longitudinal associations between activity limitations, instrumental supports and social participation in osteoarthritis: A CLSA population-based study
Establishing a non-viral transfection system for fibroblasts using branched polyethylenimine
Enhanced survival of spiral ganglion neurons (SGN) could improve hearing in patients with cochlear implants. Supplying these cells with growth factors like brain-derived neurotropic factor (BDNF) has...
Correction: Carbon price prediction based on a scaled PCA approach
Linguistic mechanisms of knowledge-exchange in a dark-web money laundering forum
Money laundering facilitates serious crime, enables the expansion of criminal operations, and destabilises economies. Extant scholarship is largely concerned with anti-money laundering approaches, wit...
Isolation and characterization of a Chlamydia muridarum tc0237 mutant from a genetic screen that is attenuated in epithelial cells
Chlamydia are obligate intracellular bacterial pathogens that infect a wide range of vertebrate hosts. Despite having highly conserved genomes, closely related Chlamydia species can exhibit distinct h...
Structure-based identification of bioactive compounds as trace amine-associated receptor 1 agonists for the therapeutic management of major depressive disorder
The global burden of major depressive disorder (MDD) drives ongoing efforts to develop safer and more targeted treatment strategies. Modern advances have identified trace amine-associated receptor 1 (...
Experts’ content validation of the parosmia, phantosmia, and anosmia test (PARPHAIT): A qualitative study
Background The parosmia, phantosmia, and anosmia test (PARPHAIT) has previously been developed as a tool for capturing quantitative and qualitative symptoms of olfactory dysfunction. Its content valid...
Genetic structure of different ethnic populations at the frontotemporal dementia risk loci
Background and purpose Frontotemporal dementia (FTD) is a devastating neurodegenerative disorder affecting behavior, language, and cognition. It has a complex and still poorly understood genetic basis...
Automated 1D Helmholtz coil design for cell biology: Weak magnetic fields alter cytoskeleton dynamics
Evidence of the biological impacts of weak magnetic fields have been reported for more than fifty years. However, research progress on such effects has been hampered by a lack of systematics in most e...
Correction: Multidimensional well-being and income inequality in Central and Eastern Europe: A comparative analysis of CEE North and CEE Continental countries
Correction: Analyzing cold hardiness (Based on DTA) of one-year-old branches of peaches
Global trends in smoking-attributable rheumatoid arthritis burden: Insights from GBD 2021
Background Smoking is one of the most significant environmental risk factors for Rheumatoid Arthritis (RA). However, there is a lack of research examining the impact of smoking trends on the RA diseas...
Breakfast consumption patterns and associated factors among adolescent high-school students in Tullo District, Eastern Ethiopia
Background There is growing proof to recommend eating breakfast has positive health and school-related outcomes for adolescents, including improved performance, attention, brain development, and physi...