PLoS ONE
Articles in this Issue
Latent representation of H&E images retains biological information in a breast cancer cohort
Imaging technologies and staining based pathology are important components of common practice cancer care. Specifically, H&E imaging is standard for almost all cancer patients. Traditionally, H&am...
A new investigation of nonalcoholic fatty liver disease: Effects of hypoxia on mitochondrial function and lipid droplet autophagy
An expanding body of research has highlighted the intimate connection between nonalcoholic fatty liver disease (NAFLD) and the dysregulation of hepatic lipid droplet autophagy as well as mitochondrial...
Investigation of anxiety levels and associated factor analysis in breast cancer patients undergoing chemotherapy with implanted venous access ports during the stable phase of disease
Aims To analyze the occurrence of anxiety and its influencing factors in stable stage breast cancer patients after chemotherapy with Implanted Venous Access Port (IVAP). Methods A total of 776 femal...
A GAN-Based Approach for enhancing security in satellite based IoT networks using MPI enabled HPC
Satellite Internet of Things (IoT) networks based on satellites are becoming increasingly critical for mission-critical applications, including disaster recovery, environmental surveillance, and remot...
Inhibition of XPO1 by selinexor enhances terminal erythroid maturation through modulation of HSP70 trafficking in severe β0-thalassemia/HbE
Ineffective erythropoiesis is a hallmark of β-thalassemia, characterized by impaired erythroid maturation and increased apoptosis of erythroid precursors in the bone marrow, resulting in chronic anemi...
Interventions for treating posterior cruciate ligament injuries of the knee in adults: A systematic review and meta-analysis protocol
Introduction There are many different surgical and conservative interventions for treating posterior cruciate ligament (PCL) injuries of the knee in adults. However, in the literature, there is no con...
Role of weight-adjusted waist circumference index and non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio in prediabetes risk: A mediation analysis
Objective This study aims to investigate the prevalence of prediabetes among U.S. adults using NHANES 2017–2023 data, explore the relationship between the weight-adjusted waist circumference index (WW...
Multi-task learning by using contextualized word representations for syntactic parsing of a morphologically rich language
We address the challenge of syntactic parsing for Urdu, a morphologically rich language, and present state-of-the-art results for both constituency and dependency parsing. This paper offers four major...
Exploring the molecular mechanisms and immune cell responses in brucellosis: Insights from gene expression profiles and immune cell scores
Background Brucellosis is a typical zoonotic disease. The study aimed to identify key molecular markers and immune cell imbalances in brucellosis by integrating transcriptomic profiling, co-expression...
Phytochemical analysis and green synthesis of silver nanoparticles using Centella asiatica leaf and stem extracts: An investigation of antibacterial activity
Centella asiatica (L.) Urban is a traditionally revered plant possessing several therapeutic applications. This research evaluated the phytochemical and antibacterial properties of Centella asiatica....
A disproportionality analysis of insulin glargine in the overall population and in pregnant women using the FDA adverse event reporting system (FAERS) database
Background Insulin glargine (IG) is a commonly prescribed medication for diabetes management in clinical practice, however, there has yet to be a comprehensive systematic study examining its associate...
Correction: Emergence of monopoly–Copper exchange networks during the Late Bronze Age in the western and central Balkans
Predicting stock returns using machine learning combined with data envelopment analysis and automatic feature engineering: A case study on the Vietnamese stock market
In financial markets, predicting stock returns is an essential task for investors. This paper is one of the first studies using business efficiency scores calculated from data envelopment analysis to...
Isolation and molecular identification of pathogens causing sea turtle egg fusariosis in key nesting beaches in Costa Rica
The global rise of fungal pathogens presents an emerging threat to biodiversity, with significant risks to species such as endangered sea turtles. The fungal disease known as sea turtle egg fusariosis...
Learn!Bio—A time-limited cross-sectional study on biosciences students’ pathway to resilience during and post the Covid-19 pandemic at a UK university from 2020–2023 and insights into future teaching approaches
Higher education in biosciences is substantiallyinformed by hands-on field trips and practical laboratory skills-training. With the first Covid-19 national lock-down in England in March 2020, on-campu...
A new external jugular venipuncture technique for efficient vascular access that exploits a murine anatomical variation
Vascular access in mice is a cornerstone of biomedical research, with peripheral venous approaches like the lateral tail vein, retrobulbar venous sinus, facial vein, and saphenous vein being common. H...
Mapping spatiotemporal distribution of forest carbon density in Xizang, China
Climate warming is a major global challenge, and forests, essential carbon sinks, are critical in mitigating its effects. Forest carbon density is a key parameter in assessing the carbon sinks. Tradit...
Effects of digital health counseling and behavioral interventions on weight management during pregnancy and postpartum: A systematic review and meta-analysis of randomized controlled trials
Objectives This systematic review aimed to evaluate the effects of digital health counseling or behavioral weight management interventions for preventing excessive gestational weight gain (GWG) among...
Training processes of World Masters Orienteering Championship medalists
The study aimed to capture the relationships between sports performance and workouts in different foot orienteer age groups. The preparation process of 49 World Masters Orienteering Championship (WMOC...
High-density LD-based structural variations analysis in ten Native and Mestizo Mexican populations
The main objective of this study was to perform a genome-wide characterization of Structural Variations (SV) based on the deviation of the expected short-range Linkage Disequilibrium (LD) between Sing...
Design and control of a novel pneumatic soft robot based on the improved particle swarm optimization algorithm
Inspired by the flexible structures found in soft organisms in nature, researchers have developed a variety of novel soft robots using flexible materials. Compared to traditional rigid robots, soft ro...
Analgesic effect of diluted nitrous oxide in rehabilitation training of patients with burn scar contracture: Study protocol for a randomized controlled trial
Background Burn patients experience severe pain when undergoing rehabilitation after skin grafting, which negatively affects their recovery. Traditional analgesic methods (such as opioids) have the ri...
Is every comparison a thief of joy? Polish validation of the Iowa-Netherlands Comparison Orientation Measure and the indirect role of social comparisons in the relationship between emotional stability and the impostor phenomenon
Social comparisons play an integral role in shaping people’s self-perceptions and how they view their accomplishments. The first purpose of our research was to introduce a Polish version of a social c...
Acceptability and feasibility of a multicomponent intervention to improve acute myocardial infarction care in Northern Tanzania: The MIMIC pilot trial
Background The Multicomponent Intervention to Improve Acute Myocardial Infarction Care (MIMIC) was developed to increase the uptake of evidence-based care for acute myocardial infarction in Tanzania....
Implementation of a marketing plan for the dissemination of the WHO SkinNTDs app in Cameroon
Background Skin-related neglected tropical diseases (sNTDs) remain a significant public health challenge in Cameroon, where limited resources, training, and infrastructure hinder early diagnosis and m...