PLoS ONE
Articles in this Issue
Global, regional, and national burden of kidney dysfunction-attributed ischemic heart disease from 1990 to 2021: A systematic analysis of the Global Burden of Disease study 2021
Background Ischemic heart disease (IHD) remains a leading cause of global morbidity and mortality, with kidney dysfunction (KD) emerging as a critical independent risk factor. This...
Heavy metal exposure and its impact on inflammatory ratios in minors: The mediating role of BMI
Background Despite existing evidence that endocrine-disrupting chemicals like heavy metals exposure impairs health of minors, the association between the exposures and inflammatory...
The PREHAAAB Trial: Multimodal prehabilitation for patients awaiting open abdominal aortic aneurysm repair – A study protocol for an international randomized controlled trial
Background Patients undergoing open abdominal aortic aneurysm (AAA) repair remain at high risk for postoperative complications, particularly when presenting with limited baseline f...
The immune checkpoint inhibitor avelumab increases aortic inflammation on [18F]FDG PET/CT: A retrospective cohort study
Background Patients with cancer treated with immune checkpoint inhibitors (ICIs) are at increased risk of cardiovascular events. Preclinical studies suggest that this may result fr...
Enhanced sentiment analysis in tourism reviews via multimodal graph convolutional networks
In recent years, multimodal sentiment analysis has gained prominence due to its ability to leverage diverse data types for improved accuracy. However, combining text and image modalities presents chal...
Prevalence and incidence of Coats disease in a large claims database
Purpose To determine the prevalence and incidence of Coats disease in the Japan Medical Data Center (JMDC) claims database....
Sex-based differences in front crawl and butterfly sprint performance in age-group swimmers
Objectives To identify the key variables influencing 50 m sprint performance in front crawl and butterfly strokes and determine the predominant predictors of sex-related performanc...
Identification of new triazoloquinoxaline amine derivatives with potent modulatory effects against Toll-like receptor 7 through pharmacophore-based virtual screening and molecular docking approaches
Toll-like receptor 7 (TLR7) plays a key role in the signaling pathways involved in immunity by recognizing pathogen-associated molecular patterns. Due to its broad effectiveness in various diseases an...
The role of internet integration in relation to farmers’ income and perceived social fairness
This study investigates how Internet embeddedness moderates the relationship between farmers’ income and perceived social fairness in rural China through the integrated lens of social comparison and r...
Overload of the lower limbs of firefighters as a result of external conditions
Background It is known that a firefighter’s uniform with all equipment will significantly increase the load on the lower limbs during landing. The higher landing height will also i...
When noise mitigates bias in human–algorithm decision-making: An agent-based model
Algorithmic systems increasingly inform human decision-making in domains such as criminal justice, healthcare, and finance. Although algorithms can exhibit bias, they are much less prone to undesirabl...
Recommendations to improve race identification in health records: A rapid scoping review
Race is a critical variable in understanding health disparities, yet health databases lack consistent practices for identifying race. This rapid scoping review aimed to examine existing recommendation...
In silico structural and docking models of dipteran FXPRLamide neuropeptides support ligand-receptor coevolution and suggest mechanisms for ligand bias
Pyrokinin (PK) neuropeptides are characterized by a conserved C-terminal FXPRLamide motif and modulate a range of physiological functions and behaviors in species spanning the Eumetazoa. The insect py...
6-Methoxyflavone targets SLC1A5 to induce ferroptosis in HeLa cells
Objective This study aimed to explore the role and molecular mechanism of 6-methoxyflavone in inducing ferroptosis in HeLa cells....
If I were you Minority and majority members evaluate relevancy and subjective experience differently while putting themselves in the other’s shoes
Previous research suggests that asymmetrical power relations between minority and majority groups manifest in various cognitive biases. However, the underlying processes driving these differences rema...
Diet-induced steatohepatitis does not cause heart failure with preserved ejection fraction in male middle-aged C57BL/6N mice
Metabolic dysfunction-associated steatohepatitis (MASH) is a condition characterized by inflammation and liver fibrosis. MASH patients are at a high risk of developing heart failure with preserved eje...
Sustained illness burden over time among Australians with myalgic encephalomyelitis/chronic fatigue syndrome
Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling chronic illness. Many people with ME/CFS (pwME/CFS) are unable to continue employment and requ...
Green synthesis of zinc oxide nanoparticles using ethanolic leaf extract of Olea europaea and its in vitro evaluation on MDA-MB-231 cancer cell lines, antibacterial and antioxidant activities
There are about 1.4 million cases of breast cancer in women that are diagnosed annually worldwide. Treatments to downregulate these tumor cells include surgery, immunotherapy, and chemotherapy. This s...
Intrusion detection using search-based learning optimized ensemble tree classifier model
An Intrusion Detection System (IDS) is an important component of cybersecurity, meant to monitor malicious behaviour, detect, and respond to unauthorized activities in computer systems or networks. Ge...
Correction: Network analysis and site selection for cross-disciplinary collaboration: The Plant and Environmental Science Building at Michigan State University
Spatiotemporal forelimb muscle activation during precise asymmetric stepping in rats
A sequence of muscle actions generates complex movements such as walking or reaching. However, how these coordinated actions subserve complex movements across animals remains unknown. While the sequen...
Long-term outcomes following drug-coated balloons versus thin-strut drug-eluting stents for treatment of in-stent restenosis in Chronic Kidney Disease (CKD Dragon-Registry)
We sought to investigated the outcomes of patients with chronic kidney disease (CKD) and drug-eluting stent (DES)-in-stent restenosis (ISR) undergoing percutaneous coronary intervention (PCI) with a d...
Potential FSH-mediated molecular pathway to regulate follicle development in striped hamsters (Cricetulus barabensis) supported by strong correlative evidence
Scientific background Rational control of rodent populations is crucial for maintaining ecosystem balance and mitigating agricultural economic losses. Follic...
Development of an automated ultrasonographic detection method for fecal retention using a transgluteal cleft approach
This study aimed to develop an artificial intelligence–based classification system using ultrasound images obtained via a transgluteal cleft scanning approach for detecting fecal retention in the lowe...
To test or not to test? Study protocol for a best-worst scaling to understand decision-making and preferences for genetic testing in moderate-risk individuals
Introduction Genetic testing is usually offered to individuals at high risk of carrying disease-causing variants. For those at moderate risk of genetic conditions, testing could al...