PLoS ONE
Articles in this Issue
MicroRNA mediated regulation in early-onset cardiac hypertrophy: Insights from the hypertrophic heart rat model
Cardiac hypertrophy is a pathological response to increased myocardial stress and a key contributor to heart failure. The Hypertrophic Heart Rat (HHR) is a well-established model for investigating pri...
Mapping rehabilitation pathways after cardiac surgery: Identifying key points for patient involvement and gaps in care
Background Cardiac rehabilitation in Denmark is cross-sectional and decentralised to municipalities, resulting in different pathways and practices. A comprehensive overview of thes...
Phytochemical characterization and antifungal activity of medicinal plant extracts against Colletotrichum species associated with anthracnose in Thailand
Colletotrichum is a major plant-pathogenic fungus responsible for anthracnose, a disease that significantly reduces crop yield and quality, thereby hindering commercial production....
Generating interaction gestures in dyadic conversations using a diffusion model
As expectations for computer graphic (CG) avatars and conversational robots increase, enhancing dialogue skills via multimodal channels is crucial for achieving fluent interactions with humans. Thus,...
The decade of China’s football reform: Evolutionary characteristics, performance evaluation, and reflections and insights
The year 2025 marks the tenth anniversary of the issuance of the General Plan of Chinese Football Reform and Development , and the deepening development of Chin...
Factor-based deep reinforcement learning for asset allocation: Comparative analysis of static and dynamic beta reward designs
Traditional asset allocation rules, while effective in stable phases, tend to erode once markets enter volatile regimes or undergo structural breaks. Research in deep reinforcement learning (DRL) has...
The cost-effectiveness of the Dutch In Balance fall prevention intervention compared to exercise recommendations among community-dwelling older adults with an increased risk of falls: A randomized controlled trial
Background Falls among older adults are a growing public health issue, and are associated with injuries and increased societal costs. Therefore, implementation of effective fall pr...
Independent and joint associations of volume and intensity of physical activity on cognitive impairment among middle-aged and elderly Chinese adults: A national longitudinal study
Background The objective of this study was to explore the longitudinal relationship between the volume and intensity of physical activity (PA) and their combined risk for cognitive...
Identification of PANoptosis-associated genes in hepatic ischemia-reperfusion injury by integrated bioinformatics analysis and machine learning
Background In the context of liver resection and transplantation, hepatic ischemia-reperfusion injury (hepatic IRI) remains a significant clinical challenge, profoundly impacting b...
Business-as-usual and fantasy planning – an analysis of equity within climate adaptation planning for sanitation in Nairobi
This paper explores the disconnect between policy rhetoric and implementation at the intersection of sanitation equity and climate change in Nairobi, Kenya. To examine the current sanitation adaptatio...
Robustness of CNN-augmented sequential models for Li-ion battery RUL prediction under data scarcity
Accurate Remaining Useful Life (RUL) prediction for Lithium-ion batteries is critical for system safety, yet its efficacy is frequently limited by data scarcity in industrial contexts. The robustness...
What role should EBU catheters play in the interventional approach to anomalous right coronary arteries? A case series
Background Percutaneous coronary intervention (PCI) for anomalous right coronary artery (ARCA) remains technically challenging due to variable ostial anatomy. The Extra Back-Up (EB...
Evaluation and screening of peanut (Arachis hypogaea L.) germplasm for nutritional and biochemical enhancement with in-vitro assessment of anti-cancer properties
Peanut breeding increasingly emphasizes nutritional enhancement and bioactive potential to support functional food development. This study assessed twenty-eight peanut genotypes for compositional dive...
Effects of biochar from algae (Sargassum spp.) on the fertility of two chlordecone contaminated West Indies soil
The unique properties of biochar (BC) have led to its increasing use as a soil management tool that improves soil fertility and enables pollutant sequestration. In the French West Indies, BC offers a...
Prevalence and associating factors for iatrogenic gliosis-like changes in surgically treated intracranial meningioma patients—A retrospective study of 255 meningioma patients
Purpose Persistent peritumoral brain edema (PTBE) following surgery of intracranial meningioma (IM) has recently been proposed to represent, in part, iatrogenic gliosis-like change...
Association between triglyceride-glucose derived indices with cardiometabolic multimorbidity: Findings from the Atherosclerosis Risk in Communities study
Background Cardiometabolic multimorbidity (CMM), characterized by the co-occurrence of diabetes mellitus (DM), stroke, and coronary heart disease (CHD), imposes substantial global...
Development of a psychological management intervention protocol for Elderly Patients with Chronic Diseases based on the Empowerment Theory: A Delphi study
Objective This study aims to establish a psychological intervention program for elderly patients with chronic diseases based on the theory of empowerment....
Promoting trustworthy file sharing: A community-governed dApp approach
In the cyber digital world, file sharing has become a cornerstone of global connectivity, facilitating the exchange of media, information, and resources among people worldwide. File sharing is already...
Genomic insights into the expansion of meropenem-resistant GPSC1-CC320 Streptococcus pneumoniae serotype 19A isolates from children under 5 years of age with invasive infections, 2018–2024
The global rise of multidrug-resistant (MDR) Streptococcus pneumoniae serotype 19A despite widespread pneumococcal conjugate vaccine (PCV) use poses an emerging...
Exploring barriers of household contact screening of index case contacts of pulmonary tuberculosis cases in Sekela district, Amhara region, Ethiopia: 2023; descriptive qualitative study
Introduction Tuberculosis (TB) remains a leading global public health challenge, with about one-third of the world’s population infected and at risk of developing active disease du...
An integrated analysis method for critical human factors and paths in hazardous chemical storage accidents based on association rule mining and bayesian networks
Hazardous chemicals possess significant inherent dangers, and accidents involving their storage can lead to severe consequences. Human factors are the primary contributors to such accidents; therefore...
Optimization of air supply mode of vehicle air conditioning based on digital thermal manikin
With the rapid development of the automobile industry, the public’s demand for automobile diversification is growing steadily.People are no longer satisfied with basic driving convenience, more attent...
Comparative effectiveness of open versus laparoscopic resection in patients with locally advanced colon cancer: Inverse probability of treatment weighting approach
Background In Saudi Arabia, colorectal cancer is one of the most common cancers. Most of colorectal cancer cases were diagnosed at an advanced stage, making the treatment process m...
Development of a CYP2D6-enhanced HepaRG cell model with improved CYP2D6 metabolic capacity
Drug-induced liver injury is a major concern in drug development, and the limitations of animal models have driven interest in human-derived in vitro models for toxicity assessment. HepaRG cell-based...
Factors associated with perceived weight gain among the adult population of Kazakhstan during the COVID-19 pandemic
Objective Obesity has been recognized as a major public health problem globally. The COVID-19 pandemic has negatively affected behavioral patterns and, as a result, the weight gain...