PLoS ONE
Articles in this Issue
Butyrate ameliorates DSS-induced ulcerative colitis in mice by facilitating autophagy in intestinal epithelial cells and modulating the gut microbiota through blocking the PI3K-AKT-mTOR pathway
Background Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease of the colon that imposes a significant global public health burden due to its recurrent and refra...
Multi-criteria group shilling attacks
The rapid advancement of technology has enabled the collection of detailed, multi-dimensional user data, paving the way for multi-criteria recommendation systems that consider diverse aspects of user...
Establishing biomarkers and clinical endpoints in myotonic dystrophy type 1 (END-DM1): Protocol of an international natural history study
Background Myotonic dystrophy type 1 (DM1) is an autosomal dominant inherited multi-system disorder that affects skeletal muscles but also many other organ systems. Molecular targe...
Anti-arthritic and endothelial protective effects of Derris scandens extract in adjuvant-induced arthritis in rats
Rheumatoid arthritis is a chronic inflammatory disease associated with a significantly increased risk of cardiovascular mortality. This study investigated the therapeutic potential of...
Analysis of spatial differentiation and influencing factors of rural industrial integration efficiency in China
The integrated development of rural industries is a primary method to accelerate rural revitalization, a practical path to promote agricultural and rural modernization, and an important means to build...
WACSAW: An adaptive, statistical method to classify movement into sleep and wakefulness states
Wearable actimeters can improve our understanding of sleep in the natural environments. Current algorithms may produce inaccuracies in specific individuals and circumstances, such as quiet wakefulness...
Intensive Care Unit admission and long-term survival in older patients after elective major noncardiac surgery: A secondary analysis
Background Intensive care unit (ICU) admission after surgery is an important part of perioperative care but was found not effective in reducing perioperative mortality. This study...
Is structural equation modeling applicable in a population health determinants assessment? An experience from the European Union
The purpose of this study is to examine the relations between health determinants and overall health within population of the European Union by using the structural equation model, particularly given...
Feasibility study of a novel technique for treating refractory ascites using a peritoneobladder shunt in a swine model
Ascites is often treated through paracentesis, which requires repeated application and poses risks. In this study, we developed a peritoneobladder shunt that allows natural ascites drainage from the p...
Effect of depression and serotonin reuptake inhibitors antidepressant treatment during pregnancy on protein expression in the human placenta: A quantitative proteomics analysis
Depression is one of the most prevalent mental health disorders affecting pregnant individuals, and serotonin reuptake inhibitors (SRIs) are the most prescribed medications to treat depressive symptom...
Thermal insulation of poly(methyl methacrylate) bone cement and hydroxyapatite coatings under induction heating of metal implants
Prosthetic joint infection after joint arthroplasty has serious consequences for patients. Finding new treatments against prosthesis infection is increasingly urgent due to the growing number of prost...
High BMI-attributed diabetic kidney disease in China versus globally, 1990–2021, with projections to 2045: Divergent trends and an accelerating burden
Objective To analyze the accelerating burden and unique trends of diabetic kidney disease (DKD) attributable to high body mass index (BMI) in China from 1990 to 2021, contextualize...
The carbon footprint of tourism businesses in Pavlodar region (Kazakhstan): Baseline assessment and decarbonization hot spots
The study presents the first detailed carbon footprint assessment of tourism businesses in Kazakhstan’s Pavlodar region, aiming to establish a baseline and identify decarbonization pathways that align...
Targeted virome deep sequencing reveals frequent herpesvirus detection in intestinal biopsies of inflammatory bowel disease patients
Background The intestinal virome is increasingly recognized for its impact on intestinal health and disease. Inflammatory bowel disease (IBD) has been linked to microbial dysbiosis...
Research on the influencing factors of user engagement in tourism short video from the perspective of configuration
Tourism short videos have become a crucial means for disseminating information and promoting tourism destinations, with user engagement directly impacting their spread and the long-term development of...
Prevalence and factors associated with adverse birth outcomes among women with chronic hypertension in Rangpur: A multi-center cross-sectional study
Background Hypertension affects approximately 3–5% of pregnancies globally, with an increased risk of adverse birth outcomes (ABOs) among mothers with chronic hypertension, which p...
Prevalence and determinants of work-related ocular symptoms among dentists of Bangladesh: A cross-sectional study
Objectives The present study aims to investigate the prevalence of work-related ocular symptoms and their associated factors among Bangladeshi dentists....
Correction: Targeting NLRP3 and AIM2 signaling pathways by Viscosol alleviates metabolic dysregulations induced inflammatory responses in diabetic neuro- and nephropathy: An in silico and in vivo study
A multiple filter-wrapper feature selection algorithm based on process optimization mechanism for high-dimensional omics data analysis
Recently, hybrid feature selection methods have demonstrated excellent performance on high-dimensional data, but many of these methods tend to yield relatively homogeneous feature subsets. To address...
Single-cell nuclear RNA-sequencing reveals dynamic changes in breast muscle cells during the embryonic development of Ding’an goose
Breast muscle is a crucial trait in poultry meat production. Previous studies have identified embryonic day 15 (E15), E21, and E31 as key time points in the breast muscle development of Ding’an goose,...
Psychometric properties of the social isolation and social network scale in community-dwelling older adults: Construct validity, reliability, and sensitivity
Background Social isolation is associated with numerous negative health outcomes in older adults. Despite growing concerns about social disconnection, there remains a need for psyc...
Bridging the cultural divide: Simulated patient encounters to enhance medical students’ cross-cultural competences – A pilot study
There is an increasing awareness of the need to include culture sensitive actions and knowledge in the medical curriculum to ensure quality care for the growing number of culturally and linguistically...
Exploring the genetic frontier: Unraveling ANRIL, PAI-1, and HNF1α in stroke progression
Background Ischemic stroke poses a notable global public health challenge, with the Kingdom of Saudi Arabia (KSA) being no exception. This multifaceted condition is affected by a c...
PyUAT: An open-source Python framework for uncertainty-aware, efficient, and scalable model-driven cell tracking
Tracking individual cells in live-cell imaging provides fundamental insights into phenotypic heterogeneity and cellular responses to environmental change. However, microbial cell tracking is particula...
M-polynomial driven machine learning models for predicting physicochemical properties of antibiotics
Accurate prediction of the physicochemical properties of drug compounds is critical for the development of effective and safe antibiotics. In this study, we employ advanced machine learning techniques...