PLoS ONE
Articles in this Issue
A screening strategy for bioactive components from Amaranth: An integrated approach of network pharmacology, molecular docking and molecular dynamics simulation
Amaranth is a traditional medicinal and forage plant with promising anti-inflammatory properties. To enhance its utilization in livestock and feed industries, this study investigat...
Deficiencies in communication between clinical microbiological laboratories and physicians may impair the diagnosis of Lyme borreliosis: A study of the use and application of serology in three neighbouring counties in Sweden
Purpose The diagnosis of Lyme borreliosis (LB) can be challenging. The aim of this study was to investigate, describe and compare the actual use, application and documentation of L...
Antibacterial efficacy of Solanum muricatum aiton metabolites against methicillin-resistant staphylococcus aureus: Insights into bioactive compounds and molecular mechanisms
The incidence of methicillin-resistant Staphylococcus aureus (MRSA) has been steadily increasing in Ethiopia over the past few decades. As a result, the need fo...
Spatial genetic diversity and populational differentiation of Ternstroemia sylvatica (Ericales: Pentaphylacaceae) in eastern Mexico
Ternstroemia sylvatica inhabits several temperate and tropical montane forests in eastern Mexico. Its current discontinuous distribution results from both natural and anthropogenic...
Correction: The dynamic of treatment-seeking in a community sample with obsessive-compulsive symptoms: A mixed method approach
Extent and causes of the collapse in the registration of innovative medications in Lebanon: A mixed-methods analysis
Objectives Delays in innovative drug registration across countries, or the “drug approval lag”, can cause inequities in treatment access, thereby worsening patient outcomes. Regist...
The effect of Tannic acid on colonic anastomosis in abdominal sepsis: An experimental study
Background This study aimed to evaluate the effect of tannic acid on colonic anastomosis in a sepsis model induced by cecal abrasion....
AI based comparison of prefrontal cortex activity between piano-majors and non-piano-major musicians during score-based playing and Motif-improvisation
This study aimed to investigate how neural activation patterns differ between pianists and non-pianist musicians during piano performance tasks, using an LSTM-Autoencoder model applied to fNIRS data....
Intelligent glucose management in hospitalized patients: Short-term glucose and adverse events prediction
The management of blood glucose in hospitalized patients is confined to retrospective interventions, preventing healthcare professionals from predicting patients’ blood glucose levels and potential ad...
Single-cell alternative polyadenylation analysis reveals mechanistic insights of COVID-19-associated neurological and psychiatric effects
COVID-19 is associated with increased risks of neurological and psychiatric sequelae. Alternative polyadenylation (APA) is ubiquitous in human genes, resulting in mRNA diversity, and has been validate...
A scoping review of interventions to prevent and treat adverse events during treatment of rifampin-susceptible tuberculosis
Background Treatment-related adverse events are one of the leading barriers to tuberculosis treatment completion but have not been the focus of late-phase clinical trials. We perfo...
Isolation and characterization of the phytopathogenic fungus Ilyonectria liriodendri from persimmon as a new susceptible host
Several members of the fungal genus Ilyonectria primarily infect plants through the roots and basal stem, causing ‘black foot’ diseases, predominantly in woody...
Prepared for the expected but unready for the unexpected: Unmet distractor expectations slow braking responsiveness but improve lane-keeping precision in a virtual driving simulation
Driving requires attentional control mechanisms to enhance the detection of driving-relevant objects and to mitigate interference from distractors. While distractor suppression can be proactively enga...
An integrated framework for multi-feature fusion and intelligent recognition of design elements: Challenges and solutions
Visual design element recognition and analysis play a critical role in various applications, ranging from creative design to cultural artifact preservation. However, existing methods often struggle wi...
Collaborative and co-Ordinated action for Medication Safety (COMS): Experience-based co-design of an intervention blueprint to improve general practice and community pharmacy collaboration
Poor communication is a key causal factor of medication safety incidents. Collaboration between community pharmacy (CP) and general practice (GP) staff is essential but hindered by multiple barriers....
Genetic association of microRNA-146a polymorphisms with the severity of coronary artery lesions in acute myocardial infarction
Background Polymorphisms situated within the microRNA-146a gene have been extensively reported to fulfill a cruci...
Persistence of human enteric viruses in artificial and human saliva
Enteric viruses, such as Adenovirus 41 (AdV41) and Coxsackievirus B3 (CVB3), are significant contributors to gastrointestinal infections, particularly among young children and immunocompromised indivi...
Monitoring deformation of seasonally frozen Yellow River bank soil: A synergetic application of the SBAS InSAR approach
The riverbanks of the Inner Mongolia reach of the Yellow River face persistent risks of deformation and collapse due to freeze-thaw cycles and hydrodynamic forces. However, most existing studies have...
Inappropriate treatment of hospital-acquired infections and associated factors among admitted adults in Wolaita Zone hospitals, Southern Ethiopia: A multi-center cross-sectional study
Background Hospital-acquired infections (HAIs) are a global health concern. Inappropriate treatment of HAIs worsens their impact, contributing to increased antimicrobial resistance...
Correction: Similarity and dissimilarity in alterations of the gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane
School-to-work transition: The role of life satisfaction, risk perception, and resilience in youth career decision-making
Young people often face uncertainty during the transition from education to work, along with high unemployment and job dissatisfaction, which is addressed in the EU Youth Strategy, highlighting the ne...
A study protocol for a multi-specialty observational cohort comparing robotic stapler and bedside stapler outcomes in robotic-assisted surgeries
Introduction Surgical staplers are essential tools in minimally invasive surgery (MIS), enabling tissue division, hemostasis, and secure anastomoses. With the growth of robotic-ass...
Systematic review of mHealth and digital health interventions to improve childhood vaccination uptake in 19 Sub-Saharan African countries
Mobile health and digital health (mHealth/DH) interventions have been shown to support immunisation programmes in Sub-Saharan Africa (SSA) and improve uptake of life-saving vaccines. As 19 SSA countri...
Lycopene inhibits ER stress and apoptosis while modulating PI3K/AKT and enhancing antioxidant and anti-apoptotic proteins
Acute kidney injury (AKI) is a critical clinical syndrome with limited therapeutic options. This study investigated the renoprotective effects of lycopene, a potent antioxidant, in both in vivo and in...
Centriflaken: An automated data analysis pipeline for assembly and in silico analyses of foodborne pathogens from metagenomic samples
Rapid and comprehensive analysis of metagenomic data from samples associated with foodborne outbreaks is of critical importance in food safety. Equally important is the need for automated analysis pip...