PLoS ONE
Articles in this Issue
Use of Kaplan-Meier and Cox regressions in the distribution of length of stay in animal shelters for pre-specified calendar periods: Definition, computation, and examples of dog length of stay in orange county California
Computations of length of stay in animal shelters rely on fixed animal cohorts. This is appropriate for research studies that pre-select cohorts, but it is problematic for operational assessments of a...
Standardizing postpartum family planning counseling guidance in Ghana: A stepped-wedge cluster randomized implementation effectiveness trial
Background Postpartum family planning can reduce morbidity and mortality for parents and children, however, up to 62% of birthing people have an unmet need for contraception due to...
Antiapoptotic BCL2 family proteins BCL-XL and MCL1 as factors predicting resistance against venetoclax plus azacitidine for patients with newly diagnosed acute myelogenous leukemia
The combination of Venetoclax (VEN), a BCL2 inhibitor, and Azacitidine (AZA), a hypomethylating agent, is the standard treatment for acute myelogenous leukemia (AML) in patients older than 65 years wh...
Uralenol, Glycyrol, and Abyssinone II as potent inhibitors of fibroblast growth factor receptor 2 from anti-cancer plants: A deep learning and molecular dynamics approach
Fibroblast Growth Factor Receptor 2 (FGFR2) plays a critical role in cellular proliferation and differentiation, and its dysregulation is associated with multiple cancers. This study integrates molecu...
A HLBDA, GA, and COA for optimal operation of distributed energy resources
Although renewable energy sources offer enormous potential to improve environmental sustainability, maximizing economic benefits inside microgrids requires resolving their intermittency and irregulari...
LDA-DETR: A lightweight dynamic attention-enhanced DETR for small object detection
The issues of complex background interference, dense distribution, and insufficient feature representation for small objects have become significant challenges and research hotspots in computer vision...
Multimodal imaging of tibialis anterior muscle adaptations to neutral-position immobilization
Muscle disuse atrophy is a frequent consequence of therapeutic immobilization following sport injuries, bone fractures, and ligament tears, often resulting in marked reduction of muscle volume, mass,...
Drospirenone promotes apoptosis in ectopic but inhibits proliferation in eutopic human endometrial stromal cells
Background Endometriosis is a complex gynecological condition characterized by endometrial tissue growing outside the uterus. In many i...
Genetic insights into number of long-term conditions and their relationship with lifespan
Aims Relationships between the genetic risk for long-term conditions (LTCs) and lifespan have been reported. However, the genetic factors underlying the total number of LTCs an ind...
Navigating physical activity after a nerve injury in the arm and hand
Peripheral nerve injuries in the arm and hand can lead to significant challenges, impacting every aspect of a person’s life. Still, rehabilitation largely focuses on hand exercises, emphasizing motor...
Effective and safe: Long-term aerosol disinfection of slightly acidic electrolyzed water causes no harm in rats
Slightly acidic electrolyzed water (SAEW) has been shown to possess strong bactericidal and virucidal properties, making it a promising candidate for spatial disinfection. In this study, we rigorously...
Energy–structure coupling mechanism and damage evolution model of red sandstone during soaking–softening process
To reveal how different soaking times affect red sandstone’s softening characteristics, this study analyzed red sandstone’s mineral composition, meso-structure, mechanical properties, and energy evolu...
Maternal slow-release nitrogen diets during late gestation optimize the energy metabolism in calves’ skeletal muscle
The current study aimed to determine the enriched biological process, through proteomic and transcriptome data, associated with maternal slow-release nitrogen diets received during late gestation on t...
Study on the influence of anti stripping agent on the rheological properties of asphalt at high and low temperatures
In order to compare the effects of different anti stripping agents on the rheological properties of asphalt at high and low temperatures, four typical anti stripping agents, amine PA-1, non amine XT-2...
Phytophthora capsici carries and differentially expresses genes for the RNA interference pathway
The RNA interference (RNAi) pathway is an epigenetic mechanism that has recently gained attention for its role in regulating the virulence of plant pathogens. However, little is known about this gene...
Application of the Er:YAG laser in pulpotomy for mature permanent teeth with pulpitis: An animal study
Objective To apply Erbium-doped Yttrium Aluminum Garnet (Er:YAG) laser in pulpotomy for experimentally induced pulpitis in mature permanent teeth of rats, and investigate whether E...
Physiological responses of Cucurbita pepo seeds to cadmium and copper stress: Differential impacts on reserve mobilization, metabolic efficiency, and growth
Heavy metal contamination poses a significant threat to agricultural productivity. This study investigated the physiological and biochemical responses of Cucurbita pepo...
Process evaluation of a supportive intervention targeting social isolation among older people in Danish senior centres: Explanatory factors of implementation failure
This article explores the implementation of a supportive intervention in Danish municipal senior centres targeting social isolation among older people. The intervention, implemented between April 2022...
Molecular characterization and phylogenetic analysis of major envelope protein gene (B2L) and ATPase protein gene (A32L) of orf virus isolates from goats in Southern, Thailand
Orf virus (ORFV), a member of the Poxviridae family, causes contagious ecthyma (CE), a viral skin disease in small ruminants. Due to its self-limiting nature, l...
An interpretable machine learning framework for adverse drug reaction prediction from drug-target interactions
Background Adverse drug reactions (ADRs) present challenges to patient safety and healthcare systems. Current pharmacovigilance methods, such as the Yellow Card Scheme (YCS), provi...
The impact of expanded access to antiretroviral treatment on engagement in HIV care and viral suppression among pregnant women living with HIV in South Africa
Background Timing of engagement in HIV care in relation to pregnancy impacts maternal outcomes and the risk of vertical transmission of HIV. Option B+, a policy that mandates offer...
Incidence and risk factors for post-stroke delirium in the elderly: A national inpatient sample (NIS) analysis
Background Post-stroke delirium (PSD) is a critical neuropsychiatric condition affecting up to 50% of elderly patients during hospitalization, often leading to poorer outcomes. Des...
Cost-effectiveness of cast treatment vs. surgery in elderly patients with substantially displaced intra-articular distal radius fractures: A trial-based economic evaluation
Background The number of surgical procedures for distal radius fractures in the elderly has increased, even though most studies show little or no benefit over cast treatment. While...
A deep state-space analysis framework for cancer patient latent state estimation and classification from EHR time-series data
Advancements in deep learning technologies and an increase in medical data have enhanced the accuracy of disease diagnosis and treatment strategies. Notably, significant progress has been made in the...
Extended thrombotic prophylaxis in COVID-19 early discharge: A retrospective cohort study
Introduction/Background Due to limits in available staff and space during the COVID-19 pandemic, home monitoring programmes were introduced, reducing strain on resources, and preve...