PLoS ONE
Articles in this Issue
Association of intraindividual differences in estimated glomerular filtration rates based on cystatin C and creatinine with dementia: A cohort study of the UK Biobank
Background Dementia is a leading cause of cognitive decline, with Alzheimer’s disease (AD) and vascular dementia (VaD) being the most common subtypes. The in...
Long-term prognostic value of microvascular obstruction by cardiac magnetic resonance in ST-segment elevation myocardial infarction
Aims Microvascular obstruction (MVO) portends a higher risk of remodelling and adverse events following ST-segment elevation myocardial infarction (STEMI). However, data regarding...
Prevalence and associated factors of non-variceal upper gastrointestinal bleeding among cirrhotic patients with upper gastrointestinal bleeding on follow-up at a Tertiary Hospital in Ethiopia
Background Liver cirrhosis is a major cause of morbidity and mortality worldwide. Non-variceal upper gastrointestinal bleeding (NVUIGB) accounts for 24–42% of bleeding episodes in...
Yield and combining ability of temperate ex-PVP introgressed and tropical maize under contrasting moisture regimes
Low grain yield and recurrent drought remain major constraints to maize production in Sub-Saharan Africa (SSA), underscoring the urgent need for hybrids with improved resilience. The use of ex-PVP (ex...
The impact of the COVID-19 pandemic on oral anticoagulation adherence in patients with atrial fibrillation managed in primary care: Results from the PRIME Registry
Background Oral anticoagulants (OACs) are critical for preventing stroke in patients with atrial fibrillation (AF), yet adherence and persistence remain suboptimal, especially in p...
Analysis of the failure state of the Cenozoic clay layer in thin bedrock coal seam mining: A case study of Sanyuan coal mine
A mechanical analysis model was constructed for the clay layer. Using a combined approach of theoretical analysis and numerical simulation, the failure state of this layer during coal seam extraction...
Residual physiological abnormalities after pulmonary endarterectomy and balloon pulmonary angioplasty in CTEPH
Introduction Pulmonary endarterectomy (PEA) is the first-line treatment for chronic thromboembolic pulmonary hypertension (CTEPH), while balloon pulmonary angioplasty (BPA) is an e...
Concurrent training in cardiac rehabilitation: A scoping review of aerobic-strength combinations in patients with coronary artery disease
Concurrent training (CT), defined as the integration of aerobic and strength exercise modalities, is increasingly implemented within cardiac rehabilitation (CR) to improve cardiovascular and musculosk...
Establishment of optimal mandibular incisor inclination: A retrospective comparison between surgery-first and conventional orthodontic approaches
Introduction Surgery-first orthodontic treatment offers early facial profile improvement and shorter treatment duration. This study investigated the incisor relationship in skeleta...
Person-centered care, shared decision-making, and service modularity in colorectal cancer treatment: A mixed-method study of patient and professional perspectives
Background Cancer care pathways improve outcomes through standardization but often lack flexibility to address individual needs. In this case study, we applied a composite model to...
Integrating contrastive cross-modal attention and stacked GRU for hand function rehabilitation robot control
With the intensification of population aging and the increasing incidence of neurological diseases, the demand for precise and intelligent control technology in hand rehabilitation robots has become m...
Efficacy of a single dose switch from aflibercept to ranibizumab in the treatment of neovascular age-related macular degeneration
Purpose To analyze morphological and functional response after administration of a single dose of ranibizumab in eyes under treat&extend aflibercept in neovascular age related...
Effects of telerehabilitation-based physical therapy for individuals with Parkinson’s disease: A systematic review protocol
Introduction The use of telerehabilitation (TR) may increase in the next years due to the appreciation and acceptance of individuals with Parkinson’s Disease (PD). The objective of...
Knowledge, attitude and practice of invasive mechanical ventilation protocolized weaning among ICU nurses and its influencing factors: A cross-sectional study
Background Many foreign countries have implemented protocolized weaning led by respiratory therapists (RTs) or nurses, which can reduce the duration of mechanical ventilation. At p...
5 Years of bipolar disorder conversations on Reddit: Methods, key topics and future directions
Bipolar disorder (BD) is a prevalent mood disorder that can be associated with serious personal, societal, and economic costs. Growing attention is being paid to the importance of including the experi...
TLR9/MyD88/NF-κB signaling mediates mental stress-induced exacerbation of psoriasis through immune dysregulation in a mouse model
Objective Psoriasis is a chronic inflammatory autoimmune disease that affects physical and mental health. Mental stress has been shown to exacerbate human psoriasis by unknown mech...
Correction: Ketogenic diet improves disease activity and cardiovascular risk in psoriatic arthritis: A proof of concept study
Factors associated with pulmonary tuberculosis in older adults: A scoping review
Tuberculosis is an infectious disease with a substantial impact on public health, with the pulmonary form representing the most significant concern. The disease poses considerable risks to the elderly...
PAH-former: Transfer learning for efficient discovery of pulmonary arterial hypertension-associated genes
Background and Aims Pulmonary arterial hypertension (PAH) is a severe disease with limited effective therapies, making the discovery of new therapeutic targets crucial. While singl...
Therapeutic role of Cousinia thomsonii in ameliorating the oxidative stress and inflammation: A comprehensive in vitro and in vivo investigation
The present study evaluated the antioxidant and anti-inflammatory properties of an edible medicinal herb, Cousinia thomsonii (CT), commonly known as Thomson’s t...
Conversion from farmland to orchard or agroforestry improves soil carbon sequestration by enhancing microbial biological activity in Northwest China
Land-use conversion from conventional farmland to orchard or agroforestry systems holds great potential for enhancing soil organic carbon (SOC) sequestration and microbial activity in arid regions. Th...
“Opening the Box to Explore the Contents”: A study on the design elements of museum cultural and creative blind boxes based on consumer preferences – Taking the Macao Museum as an example
This study adopts a consumer preference-driven approach and employs a mixed-methods research methodology to construct a systematic design decision-making model. By integrating literature review analys...
Shotgun metagenomic profiling reveals Bacillus-dominated bacterial communities in urban rooftop and surface garden soils of Bangladesh
Urban rooftop and surface garden systems play a critical role in food security in densely populated regions, yet their soil microbiomes remain understudied. To date, no baseline data exists on rooftop...
Correction: Collagen composition in equine exuberant granulation tissue reflects tissue immaturity
Hypomorphic mutations in ura6 confer 5-FOA resistance in fission yeast
Genome integrity is essential for cellular survival and adaptation across diverse physiological states. The fission yeast Schizosaccharomyces pombe relies on co...