PLoS ONE
Articles in this Issue
The journey to diagnosis and care of functional neurological disorder (FND)
Purpose Functional neurological disorder (FND) is a common condition, associated with high disability and healthcare costs, and poor treatment access. This q...
Cryptic diversity in Astroblepus (Siluriformes: Astroblepidae): Integrative taxonomy reveals evolutionary complexity in the Esmeraldas River Basin, Ecuador
Astroblepus is a genus of endemic Andean catfishes with problematic taxonomy because of cryptic diversity, ambiguous historical descriptions, and morphological plasticity. This stu...
Association between physical activity and mental health (emotional and peer problems) in children and adolescents, a national follow-up study
Background While extensive evidence demonstrates the beneficial effects of physical activity on adult mental health, research examining these relationships in childhood remains lim...
Stomatal responses of differently CO2-acclimated plants to natural and experimental CO2 gradients
Stomata, the microscopic pores in the epidermis of plant leaves, facilitate gas exchange between the leaf interior and the external environment and thus play a pivotal role in the global carbon, water...
Healthcare resource utilization and cost burden of COVID-19 according to vaccination status in adults in Ontario, Canada, 2021–2023
Aims This study aims to describe healthcare resource utilization (HCRU) and cost burden associated with COVID-19 cases in Ontario, Canada, and assess variations by vaccination stat...
Unburnable carbon in the rapidly warming Arctic: Mapping spatial relationships among oil and gas development, ecologically sensitive areas and Indigenous Peoples’ lands
As global temperatures rise due to carbon emissions from fossil fuels, it is estimated that around 60% of oil and gas reserves —termed 'unburnable carbon'—must remain underground to meet international...
A Monte Carlo simulation study of sample size requirements for the Graded Response Model
Background The graded response model (GRM) is commonly used in psychometrics to analyze ordinal response data. Despite its growing application in scale devel...
The effects of temperature on nestling growth in a songbird depend on developmental constraints
Climate change can adversely impact animals, especially those that cannot independently thermoregulate or avoid exposure to temperature variation. Altricial bird nestlings may be particularly vulnerab...
A flow cytometric assay of murine erythrocyte osmotic fragility
Flow cytometric test of erythrocyte osmotic fragility (EOF) is a critical diagnostic tool for evaluating membrane stability in hemolytic disorders and storage lesions of human erythrocytes. However, t...
A cross-sectional study on the impact of early systematic antidepressant therapy on positive/negative affect and impulsivity in euthymic bipolar disorder patients
Background and objectives Due to an initial misdiagnosis, bipolar patients who experienced a depressive episode as their first onset were often treated with antidepressants, and co...
Cadmium-induced DAG-PKC/IP3-Ca2+ double signaling pathway and cell injury in gill of freshwater crabs Sinopotamon henanense
Cadmium (Cd) is an extremely toxic heavy metal and widespread in the environment, which has been demonstrated closely associated with numerous organs damage and even death. To evaluate the signaling p...
Forecasting under-five stunting in Ethiopia using classical and machine learning time series models
Background The prevalence of under-five stunting in Ethiopia remains above 30%, which, according to World Health Organization (WHO), constitutes a major public health concern. Stun...
In vivo mouse model of calcific myonecrosis induced by injury
Skeletal muscle is the major tissue that provides a space and source for bone, which is formed by osteoblasts through the secretion of extracellular matrices, such as type I collagen, and the depositi...
Single-cell multiomics data analysis of potential receptors and therapeutic drugs for epilepsy patients comorbid with depression
Depression frequently cooccurs with epilepsy (EP) and has become a focus of clinical management, but effective pharmacological interventions remain limited. In this study, single-cell RNA sequencing (...
Expression of Concern: Toll-Like Receptor 2 Targeted Rectification of Impaired CD8+ T Cell Functions in Experimental Leishmania donovani Infection Reinstates Host Protection
Overexpression generates aberrant distribution of endocytic regulators - the case of the Rab11/LAMP1 compartment
While the uptake of cargos via endocytosis and the subsequent trafficking through the cell is crucial for normal cellular function and tightly regulated, the study of this bears challenges. Most studi...
Attenuation of higher-order acoustic modes in a cylindrical waveguide using lined panel-cavity coupling
This work presents a mode-matching framework for analyzing acoustic attenuation in a waveguide that incorporates a centrally lined chamber, membrane discs at the interfaces, and extended inlet–outlet...
When merchandise crowds the aisle and carts crowd the shopper: Joint effects on sales
This research examines how fixture-induced spatial crowding suppresses in-store purchasing and how shopping aids—particularly carts—amplify this effect by expanding users’ peripersonal space and dimin...
Casting a long shadow: Exploring the link between childhood maltreatment and cancer in adulthood
Childhood adversities, including physical abuse, sexual abuse, and exposure to parental domestic violence (PDV), have been linked to negative health outcomes in adulthood, yet their specific associati...
Magnitude and determinants of delivery complications among women in selected hospitals of West Shoa, Oromia, Ethiopia: A multicentered cross-sectional study
Background The occurrence of Complications during delivery is a significant contributor to the health of the mothers and neonates, particularly in low-resource settings like Ethiop...
Investigating the ME/CFS experience through qualitative analysis of memorial entries
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an impairing chronic condition characterized by exhaustion and worsening symptoms following exertion, often accompanied by pain, sleep is...
Single-cell atlas of gastric cancer reveals malignant epithelial evolution and regulatory reprogramming of the tumor microenvironment
The inflammation–intestinal metaplasia (IM)–carcinoma cascade has been proposed as a framework for gastric cancer (GC) development, yet the cell-level heterogeneity and microenvironmental remodeling u...
Risk factors and outcomes of emerging Listeria monocytogenes infection in Pakistan: Insights from a tertiary care hospital
Background Listeria monocytogenes is a Gram-positive rod responsible for listeriosis. It has emerged as a significant foodborne pathoge...
The Cambridge Questionnaire for Apathy and Impulsivity Traits (CamQUAIT): a novel assessment tool for frontotemporal lobar degeneration-related syndromes
State of the Art Apathy and impulsivity are common in syndromes associated with frontotemporal lobar degeneration (FTLD). They are associated with high carer distress and poor pati...
Evaluation of large language models in medical examinations: A scoping review protocol
Introduction Standardized medical examinations, used to assess trainee clinical competencies, provide a rigorous means to verify LLM accuracy and reliability in medical contexts. A...